[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100361063":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":35,"centralContacts":40,"locations":50,"responsibleParty":296,"collaborators":300,"id":306,"slug":307,"hasResults":308,"nctId":309,"briefTitle":310,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":313,"sex":314,"minAge":10,"maxAge":10,"enrollmentInfo":315,"targetDuration":318,"studyType":319,"phases":10,"briefSummary":320,"conditions":321,"keywords":323,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":336},{"fullName":5,"class":6},"University Hospital Tuebingen","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Primary participant:",null,"Participants affected by hereditary spastic paraplegia (HSP) or a phenotypically related disorder Primary participants will be followed at annual intervals. The workup includes clinical, imaging, sensor-based, patient\u002Fobserver reported and molecular outcome parameters and biosampling.\n\nParticipants with unknown genetic diagnosis may receive genetic testing including whole exome or whole genome sequencing and other OMICS techniques.",[13,14],"Other: Clinical rating scale to measure disease severity and progression","Diagnostic Test: Next-Gen Sequencing (NGS)",{"label":16,"type":10,"description":17,"interventionNames":18},"Secondary participant\u002F First or second-degree","First or second degree unaffected family members of primary participants. Secondary participants may undergo the same study procedures as primary participants.",[14],{"label":20,"type":10,"description":21,"interventionNames":22},"Unrelated healthy control","Unrelated healthy controls Healthy controls may undergo the same study procedures as primary participants.",[14],[24,30],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Clinical rating scale to measure disease severity and progression","A 13-item scale to rate functional impairment occurring in pure forms of spastic paraplegia (SP). Additional symptoms constituting a complicated form of SP are recorded in an inventory.",[9],[29],"Spastic Paraplegia Rating Scale (SPRS)",{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"DIAGNOSTIC_TEST","Next-Gen Sequencing (NGS)","Whole Genome Sequencing, Whole Exome Sequencing, Transcriptomics, Proteomics, Metabolomics",[9,16,20],[36],{"name":37,"affiliation":38,"role":39},"Rebecca Schüle, PD Dr.","University Hospital Tübingen","PRINCIPAL_INVESTIGATOR",[41,46],{"name":37,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","+49 7071 29","85653","rebecca.schuele-freyer@uni-tuebingen.de",{"name":47,"role":42,"phone":43,"phoneExt":48,"email":49},"Ludger Schöls, Prof. Dr.","85548","ludger.schoels@uni-tuebingen.de",[51,77,97,118,134,156,173,189,207,225,241,257,279],{"facility":52,"status":53,"city":54,"state":10,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"University Innsbruck","RECRUITING","Innsbruck","6020","Austria","AT",{"type":59,"coordinates":60},"Point",[61,62],11.39454,47.26266,{"lat":62,"lon":61},[65,69,72,74],{"name":66,"role":42,"phone":67,"phoneExt":10,"email":68},"Matthias Amprosi","+43 512 504 83686","matthias.amprosi@i-med.ac.at",{"name":70,"role":42,"phone":67,"phoneExt":10,"email":71},"Sylvia Bösch","sylvia.boesch@i-med.ac.at",{"name":73,"role":39,"phone":10,"phoneExt":10,"email":10},"Sylvia Bösch, MD",{"name":75,"role":76,"phone":10,"phoneExt":10,"email":10},"Matthias Amprosi, MD","SUB_INVESTIGATOR",{"facility":78,"status":53,"city":79,"state":10,"zip":80,"country":81,"countryCode":82,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"German Center for Neurodegenerative Diseases (DZNE) Bonn","Bonn","53127","Germany","DE",{"type":59,"coordinates":84},[85,86],7.09549,50.73438,{"lat":86,"lon":85},[89,93,95],{"name":90,"role":42,"phone":91,"phoneExt":10,"email":92},"Thomas Klockgether","+49 228 28715726","Thomas.Klockgether@dzne.de",{"name":94,"role":39,"phone":10,"phoneExt":10,"email":10},"Thomas Klockgether, MD",{"name":96,"role":76,"phone":10,"phoneExt":10,"email":10},"Xenia Kobeleva, MD",{"facility":98,"status":53,"city":99,"state":10,"zip":100,"country":81,"countryCode":82,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"University of Erlangen","Erlangen","91054",{"type":59,"coordinates":102},[103,104],11.00783,49.59099,{"lat":104,"lon":103},[107,111,114,116],{"name":108,"role":42,"phone":109,"phoneExt":10,"email":110},"Susanne Seifert","+49 9131 85 44751","susanne.seifert@uk-erlangen.de",{"name":112,"role":42,"phone":109,"phoneExt":10,"email":113},"Pia-Marie Pryssok","pia-marie.pryssok@uk-erlangen.de",{"name":115,"role":39,"phone":10,"phoneExt":10,"email":10},"Jürgen Winkler, MD",{"name":117,"role":76,"phone":10,"phoneExt":10,"email":10},"Heiko Gassner, Dr. Phil.",{"facility":119,"status":53,"city":120,"state":10,"zip":121,"country":81,"countryCode":82,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"University Medicine Essen","Essen","45147",{"type":59,"coordinates":123},[124,125],7.01228,51.45657,{"lat":125,"lon":124},[128,132],{"name":129,"role":42,"phone":130,"phoneExt":10,"email":131},"Sylwia Kante","+49 201 - 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Primary participant: Clinical or genetic diagnosis of HSP or a related disorder\n  2. Secondary participant: Unaffected family member (1st or 2nd degree relative) of primary participant (with the above-mentioned restrictions for special populations) able to give informed consent\n  3. Unrelated healthy control able to give informed consent\n\n     AND\n* Written informed consent\n\nAND\n\n\\- Participants are willing and able to comply with study procedures\n\nExclusion criteria:\n\n* Missing informed consent of primary or secondary participant\u002F healthy control\u002F legal representatives\n* For controls: evidence of a neurodegenerative disease or movement disorders; inability to give informed consent",true,"ALL",{"count":316,"type":317},2000,"ESTIMATED","20 Years","OBSERVATIONAL","The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders in a prospective multicenter natural history study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the genetic etiology and molecular mechanisms of these diseases.",[322],"Hereditary Spastic Paraplegia",[322,324,325,326],"Biomarker","Genetic etiology","Molecular mechanisms","2021-05-18",{"date":329,"type":330},"2021-05-19","ACTUAL",{"date":332,"type":330},"2019-10-14",{"date":334,"type":317},"2041-08",{"name":298,"class":6},13]