[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536407":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":38,"centralContacts":42,"locations":52,"responsibleParty":73,"collaborators":75,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":23,"eligibilityCriteria":85,"healthyVolunteers":82,"sex":86,"minAge":87,"maxAge":23,"enrollmentInfo":88,"targetDuration":23,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":23,"overallStatus":55,"whyStopped":23,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Steno Diabetes Center Greenland","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention arm","EXPERIMENTAL","All participants will undergo examination for genom sequencing, diabetic complications and obstructive sleep apnea. Treatment for these conditions will not be randomized, but will be offered any participant who fulfills the excision treatment criteria",[13,14,15,16],"Genetic: Whole genome sequencing","Diagnostic Test: VAGUS","Diagnostic Test: NightOwl","Device: CPAP",[18,24,29,33],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"GENETIC","Whole genome sequencing","Screening for MODY diabetes. Diabetic treatment will be adjusted based on the participant's diabetic genotype.",[9],null,{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":23},"DIAGNOSTIC_TEST","VAGUS","To examine for Cardiovasculare Autonomic Neuropathy participants will be tested with the handheld Vagus device (Medicus Engineering, Aarhus, Denmark). Participants are instructed to perform three cardiovascular reflex tests (CARTs) after lying still in supine position for 5 minutes to record heart rate at rest. CARTs include supine-to-upright position, deep-breathing, and valsalva maneuver. From each CART the ratio based on the shortest and longest R-R-interval at predefined timepoints in the recording is used to assess the possibility of CAN",[9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":23},"NightOwl","Participants will be examined for sleep apnea for 3 nights using the NightOwl (Ectosense, Belgium) device, which measuring Peripheral Arterial Tonometry (PAT) in the index finger. The results of the examination will is uploaded via the patient's smartphone to an online platform accessible to healthcare providers. Participants with signs of sleep apnea will receive a confirmatory cardiorespiratory monitoring using the Nox T3s (Noxturnal, ResMed), and the results will be compared.",[9],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":23},"DEVICE","CPAP","Participants with an Apnea-Hypoapnea-Index above 30, or above 15 with symptoms of sleep apnea, will be offered treatment with continuous positive airway pressure (CPAP).",[9],[39],{"name":40,"affiliation":5,"role":41},"Marit Eika Jørgensen, Md. Phd","PRINCIPAL_INVESTIGATOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":23,"email":47},"Mads Jensen, MD.","CONTACT","+299 34 46 23","MMSN@peqqik.gl",{"name":49,"role":45,"phone":50,"phoneExt":23,"email":51},"Marit Eika Jørgensen, MD. Ph.d","+299 34 43 24","MAEJ@peqqik.gl",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Steno Diabetes Center Greenland, Queen Ingrids Hospital","RECRUITING","Nuuk","Sermersooq","3900","Greenland","GL",{"type":62,"coordinates":63},"Point",[64,65],-51.72157,64.18347,{"lat":65,"lon":64},[68,70],{"name":69,"role":45,"phone":46,"phoneExt":23,"email":47},"Mads Mose Jensen, MD.",{"name":71,"role":45,"phone":72,"phoneExt":23,"email":51},"Marit Eika Jørgensen, Md. Ph.d","34 43 24",{"type":74,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[76,78],{"name":77,"class":6},"Zealand University Hospital",{"name":79,"class":6},"University of Copenhagen","100536407","phenotypic-and-genotypic-characterization-of-patients-with-dysmetabolism-in-greenland-100536407",false,"NCT06264427","Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland","Inclusion Criteria:\n\n* Type 2 diabetes and\u002For morbid obesity (BMI \\>40)\n* Over 18 years old\n\nExclusion Criteria:\n\n* Does not speak either English, Danish or Greenlandic","ALL","18 Years",{"count":89,"type":90},1000,"ESTIMATED","INTERVENTIONAL",[93],"NA","The goal of this clinical trial is to perform a detailed description of the feno- and genotype of people living with type 2 diabetes and severe obesity who are linked to care at Steno Diabetes Center Greenland.\n\nThe main questions it aims to answer are:\n\n* Are monogenetic diabetes variants associated with the same risk of developing late diabetic complications as other types of diabetes?\n* Can genotyping and thereby personalized medicine be implemented in Greenland, and can personalized medicine lead to improved treatment?\n* What is the prevalence of sleep apnea among high-risk individuals in Greenland?\n* Is it possible to develop and implement a simple algorithm for the identification of sleep apnea in Greenland that can ensure treatment of severe sleep apnea?\n\nParticipants will:\n\n* Answer WHO-5 and FOSQ-10 questionnaires regarding quality of life and functional outcomes of sleepiness\n* Perform VAGUS examinations for Cardiovasculare Autonomic Neuropathy\n* Clinical examination of height, weight, circumference of hip, waist and neck, Friedman tonsil and tongue score, nasal air flow, nasal septal deviation\n* Blood samples for full genome sequencing",[96,97,98,99,100,101],"Diabetes Mellitus, Type 2","Obesity, Morbid","Obstructive Sleep Apnea","MODY","Diabetic Retinopathy","Diabetic Neuropathies","2024-02-15",{"date":104,"type":105},"2024-02-20","ACTUAL",{"date":107,"type":105},"2022-07-15",{"date":109,"type":90},"2026-12-31",{"name":5,"class":6},1]