[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633241":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":28,"locations":38,"responsibleParty":57,"collaborators":20,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":20,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":83,"whyStopped":20,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University Hospital, Montpellier","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Characterize and compare patients with and without CRSwNP","EXPERIMENTAL","Experimental: Characterize and compare patients with and without CRSwNP Assessment of rheological and inflammatory variables",[13],"Procedure: Sinonasal sample collection and inflammatory assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Sinonasal sample collection and inflammatory assessment","Collection of sinonasal secretions by blowing onto an aluminum plate Collection of blood sample: 7 ml for serum isolation to create a serum bank Biopsy of the middle turbinate head: under nasal endoscopy, a millimetric tissue sample will be taken from the middle turbinate mucosa using biopsy forceps",[9],null,[22,25],{"name":23,"affiliation":5,"role":24},"Valentin FAVIER, MD","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":5,"role":27},"Jérémy CHARRIOT","STUDY_DIRECTOR",[29,35],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Valentin Favier, MD","CONTACT","04 67 33 67 33","33","v-favier@chu-montpellier.fr",{"name":26,"role":31,"phone":36,"phoneExt":33,"email":37},"04 67 33 59 37","j-charriot@chu-montpellier.fr",[39],{"facility":40,"status":20,"city":41,"state":20,"zip":20,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University hospital Montpellier","Montpellier","France","FR",{"type":45,"coordinates":46},"Point",[47,48],3.87635,43.61093,{"lat":48,"lon":47},[51,52,54,55],{"name":23,"role":31,"phone":32,"phoneExt":33,"email":34},{"name":53,"role":31,"phone":36,"phoneExt":33,"email":37},"Jérémy CHARRIOT, MD",{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":53,"role":56,"phone":20,"phoneExt":20,"email":20},"SUB_INVESTIGATOR",{"type":58,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100633241","phenotyping-of-type-2-inflammation-profile-by-rheology-of-nasal-secretions-and-tissue-quantification-of-eosinophilic-polymorphonuclear-cells-in-the-middle-turbinate-100633241",false,"NCT07524127","Phenotyping of Type 2 Inflammation Profile by Rheology of Nasal Secretions and Tissue Quantification of Eosinophilic Polymorphonuclear Cells in the Middle Turbinate","PheRhEos","Inclusion Criteria:\n\n* Patient requiring sinonasal surgery\n* For patients in the CRSwNP group:\n\nPresence of nasal polyposis defined according to EPOS 2020 recommendations:\n\nClinical examination revealing, for at least 12 weeks prior to inclusion, 2 or more of the following symptoms:\n\n* Nasal congestion\n* Rhinorrhea (anterior\u002Fposterior)\n* Or a Facial pain\u002Fpressure\n* Or a Reduced or lost sense of smell AND visible polyps in both nasal cavities on endoscopic examination of the middle meatus (regardless of size).\n\nExclusion Criteria:\n\n* Inability to provide a sinonasal secretion sample by blowing\n\n  * Conditions causing secondary nasal polyposis (e.g., cystic fibrosis, ciliary dyskinesia, immune disorders, allergic fungal sinusitis)\n  * Illiteracy\n  * Lack of consent\n  * Legal protection status (guardianship, curatorship, etc.)\n  * No social security coverage\n  * Persons deprived of liberty by judicial or administrative decision\n  * Participation in another study with an ongoing exclusion period","ALL","18 Years","85 Years",{"count":70,"type":71},60,"ESTIMATED","INTERVENTIONAL",[74],"NA","This monocentric, interventional study (category RIPH2) aims to characterize the rheological properties of sinonasal secretions in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). The primary objective is to determine differences in mucus viscosity between CRSwNP patients and a control group. By establishing a correlation between local rheology and systemic Type 2 inflammation biomarkers, the study seeks to develop a non-invasive, rapid \"point-of-care\" tool to refine patient phenotyping and improve the personalization of biological treatments.",[77],"Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)",[79,80,81,82],"Rheology","Nasal Polyposis","mucus","T2 inflammation","NOT_YET_RECRUITING","2026-04-09",{"date":86,"type":87},"2026-04-13","ACTUAL",{"date":89,"type":71},"2026-08-01",{"date":91,"type":71},"2028-05-01",{"name":5,"class":6},1]