[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634965":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":59,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":26,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Lahore","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sham Photobiomodulation (LLLT)","PLACEBO_COMPARATOR","Participants in this group will receive sham laser therapy using an identical device with no therapeutic laser emission. The device will be applied in the same manner, duration, and frequency as the experimental group to maintain blinding.",[13,14],"Device: Photobiomodulation (Low-Level Laser Therapy)","Device: sham Photobiomodulation (LLLT)",{"label":16,"type":17,"description":18,"interventionNames":19},"Photobiomodulation Therapy (LLLT)","EXPERIMENTAL","Participants in this group will receive low-level laser therapy applied bilaterally to multiple muscle groups, including upper trapezius, biceps brachii, posterior deltoid, lumbar paraspinals, gluteus maximus, and vastus lateralis.\n\nEach muscle will be treated at 16 points spaced 1 cm apart, with an energy delivery of 4 Joules per point (total 64 Joules per muscle). The therapy will be administered three times per week for 8 weeks (total 24 sessions).",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Photobiomodulation (Low-Level Laser Therapy)","Low-level laser therapy will be delivered using a Class 3B laser device (808 nm wavelength, 100 mW power output). The laser will be applied in contact mode using a static technique perpendicular to the skin surface.\n\nTreatment will target bilateral muscle groups: upper trapezius, biceps brachii, posterior deltoid, lumbar paraspinals, gluteus maximus, and vastus lateralis. Each muscle will receive irradiation at 16 points spaced 1 cm apart, delivering 4 Joules per point (total 64 Joules per muscle).\n\nSessions will be conducted three times per week for 8 weeks (total 24 sessions).",[16,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"sham Photobiomodulation (LLLT)","Sham laser therapy will be administered using the same device without emission of therapeutic laser energy. The device will appear active and will be applied with identical procedures, duration, and frequency as the active treatment to ensure participant blinding.",[16,9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Dr Adil Amir Ali Dr Aadil Amir Ali, PhD","CONTACT","923002929464","aadilamirali@hotmail.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":26,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"The larkana General hospital , larkana","RECRUITING","Larkana","Sindh","Pakistan","PK",{"type":46,"coordinates":47},"Point",[48,49],68.21204,27.55898,{"lat":49,"lon":48},[52,56],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":55},"Dr Naseebullah","923337201393","larkanageneralhospital@gmail.com",{"name":57,"role":58,"phone":26,"phoneExt":26,"email":26},"ADIL AMIR ALI","PRINCIPAL_INVESTIGATOR",{"type":58,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Aadil Ameer Ali","Prof","100634965","photobiomodulation-in-chronic-fatigue-syndrome-100634965",false,"NCT07546539","Photobiomodulation in Chronic Fatigue Syndrome","The Role of Photobiomodulation in Patients With Chronic Fatigue Syndrome","Inclusion Criteria\n\n* Age 18-60 years\n* Diagnosis of a CFS according to the 2015 Institute of Medicine criteria\n* Fatigue Severity Scale (FSS) score ≥ 4\n* Ability to understand study procedures and provide informed consent\n\nExclusion Criteria\n\n* Comorbid psychiatric conditions (e.g., major depression, schizophrenia)\n* Current use of corticosteroids or immunomodulators\n* Known photosensitivity or dermatologic contraindications to LLLT\n* Participation in structured exercise programs more than twice weekly\n* Diagnosed malignancy or active infection -Not willing to be the part of study -","ALL","18 Years","60 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to evaluate whether photobiomodulation therapy (low-level laser therapy) can reduce fatigue and improve quality of life in patients with chronic fatigue syndrome (CFS). The study will include adults aged 18-60 years diagnosed with chronic fatigue syndrome.\n\nThe main questions it aims to answer are:\n\nDoes photobiomodulation therapy significantly reduce fatigue levels as measured by the Fatigue Severity Scale (FSS) and Multidimensional Fatigue Inventory (MFI-20)? Does photobiomodulation therapy improve pain, functional capacity, sleep quality, and psychological well-being in patients with chronic fatigue syndrome?\n\nResearchers will compare the low-level laser therapy group with a placebo (sham laser) group to determine whether photobiomodulation therapy leads to greater improvements in fatigue, pain, and overall quality of life.\n\nParticipants will:\n\nReceive either active low-level laser therapy or placebo treatment three times per week for eight weeks Undergo assessments of fatigue, pain, functional capacity, quality of life, sleep quality, and psychological well-being at baseline and follow-up intervals (3, 6, and 12 months)",[80,81],"Chronic Fatigue Syndrome (CFS)","Quality of Life",[83,84,85,86,87,88],"PHOTOBIOMODULATION","LOW-LEVEL LASER THERAPY","Chronic Fatigue Syndrome","Rehabilitation","Physiotherapy","Fatigue","2026-06-21",{"date":91,"type":92},"2026-06-24","ACTUAL",{"date":94,"type":92},"2026-06-15",{"date":96,"type":74},"2026-09",{"name":5,"class":6},1]