[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643347":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":65,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":96,"whyStopped":26,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Universidad Catolica Santiago de Guayaquil","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Scaling and Root Planing (SRP)","ACTIVE_COMPARATOR","Hemiarch treated with conventional non-surgical periodontal therapy consisting of scaling and root planing alone.",[13],"Procedure: Scaling and Root Planing",{"label":15,"type":16,"description":17,"interventionNames":18},"Scaling and Root Planing Plus Antimicrobial Photodynamic Therapy (SRP + aPDT)","EXPERIMENTAL","Hemiarch treated with conventional scaling and root planing combined with adjunctive antimicrobial photodynamic therapy using toluidine blue O and low-level laser irradiation.",[13,19],"Procedure: Antimicrobial Photodynamic Therapy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Scaling and Root Planing","Conventional non-surgical periodontal therapy performed using ultrasonic and manual instrumentation to remove subgingival biofilm and calculus.",[9,15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Antimicrobial Photodynamic Therapy","Adjunctive antimicrobial photodynamic therapy using toluidine blue O as photosensitizer activated with a 650 nm low-level laser following scaling and root planing.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"GABRIELA G ZAMBRANO MANZABA, DDS","CONTACT","+19546298543","gabriela.zambrano06@cu.ucsg.edu.ec",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Dental School, Catholic University of Santiago de Guayaquil (UCSG)","Guayaquil","Guayas","090101","Ecuador","EC",{"type":46,"coordinates":47},"Point",[48,49],-79.88621,-2.19616,{"lat":49,"lon":48},[52,55,57,60,63],{"name":33,"role":34,"phone":53,"phoneExt":26,"email":54},"9546298543","gabriela.manzaba30@gmail.com",{"name":56,"role":34,"phone":53,"phoneExt":26,"email":36},"GABRIELA ZAMBRANO MANZABA, DDS",{"name":58,"role":59,"phone":26,"phoneExt":26,"email":26},"PABLO M REYES CUENCA, DDS","SUB_INVESTIGATOR",{"name":61,"role":62,"phone":26,"phoneExt":26,"email":26},"GABRIELA GUADALUPE ZAMBRANO MANZABA, DDS","PRINCIPAL_INVESTIGATOR",{"name":64,"role":59,"phone":26,"phoneExt":26,"email":26},"HECTOR A LEMA GUTIERREZ, DDS",{"type":62,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Gabriela Guadalupe Zambrano Manzaba","Principal Investigador","100643347","photodynamic-therapy-as-an-adjunct-in-periodontal-treatment-100643347",false,"NCT07633405","Photodynamic Therapy as an Adjunct in Periodontal Treatment","Clinical Evaluation of Photodynamic Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Periodontal Disease: A Split-Mouth Randomized Controlled Clinical Trial","PDT-PERIO","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* Diagnosis of Stage I, II, III, or IV periodontitis according to the 2018 World Workshop Classification.\n* Presence of at least two hemiarches with periodontal pockets ≥5 mm suitable for a split-mouth design.\n* Systemically healthy individuals.\n* No periodontal treatment received within the previous 6 months.\n* No use of antibiotics, anti-inflammatory drugs, or antiseptic mouth rinses within the previous 3 months.\n* Ability and willingness to provide written informed consent and attend follow-up visits.\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases that may affect healing or immune response.\n* Use of antibiotics, corticosteroids, or immunosuppressive medications within the previous 3 months.\n* Active smokers consuming more than 10 cigarettes per day.\n* Pregnant or breastfeeding women.\n* Presence of dental implants, defective restorations, or teeth with Grade III mobility in the selected study sites.\n* Known allergy to toluidine blue O or any component of the photosensitizer.\n* Individuals unable or unwilling to attend the 30-day follow-up visit.","ALL","18 Years","65 Years",{"count":80,"type":81},30,"ESTIMATED","INTERVENTIONAL",[84],"NA","This study aims to evaluate the clinical effectiveness of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) in the treatment of periodontitis. A split-mouth design will be used, in which one hemiarch receives conventional SRP and the contralateral hemiarch receives SRP combined with aPDT. Clinical periodontal parameters, including probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI), and gingival index (GI), will be assessed at baseline and 30 days after treatment. The study seeks to determine whether adjunctive aPDT improves periodontal outcomes compared with conventional non-surgical periodontal therapy alone.",[87,88],"Periodontitis","Periodontal Disease",[87,88,28,90,91,92,93,94,95],"Photodynamic Therapy","aPDT","SRP","Clinical attachment level","Low level Laser therapy","Gingival Index","NOT_YET_RECRUITING","2026-06-02",{"date":99,"type":100},"2026-06-08","ACTUAL",{"date":102,"type":81},"2026-07-28",{"date":104,"type":81},"2026-09-27",{"name":5,"class":6},1]