[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595965":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":50,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":20,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":20,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Physical capacity training","EXPERIMENTAL","Physical capacity training is a comprehensive modified cardiac rehabilitation program consisting of aerobic and resistance exercise. Participants will attend a total of 36 sessions of training.",[13],"Behavioral: Physical capacity training for chronic stroke - building aerobic capacity and muscle strength",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Physical capacity training for chronic stroke - building aerobic capacity and muscle strength","The general format of each exercise session includes assessment of resting heart rate (HR), blood pressure (BP), and rating of perceived exertion (RPE) followed by a 5-minute warm-up, a minimum of 30 minutes of aerobic exercise followed by 25 minutes of resistance exercise. Aerobic exercise will always include a minimum of 10 minutes of walking (overground or treadmill) at the prescribed intensity followed by cycle, arm or rowing ergometry. Sessions will begin at a target intensity of \\~60% heart rate reserve (HRR) determined from the exercise tolerance test performed at baseline and calculated using Karvonen's formula. The goal will be to increase training intensity by \\~5% HRR every \\~3 weeks and progressed as tolerated. Resistance exercise will target all major muscle groups and include multiple sets dosed at the 10-repetition to fatigue level (\\~75% of the 1-repetition maximum). Resistance exercises will be progressed with improvements in strength or as tolerated.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Ryan Ross","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Ryan E Ross, Ph.D.","CONTACT","843-792-3477","rossre@musc.edu",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-79.93275,32.77632,{"lat":43,"lon":42},[46,47],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},{"name":27,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":23,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Assistant Professor",[51],{"name":52,"class":53},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100595965","physical-capacity-building-for-chronic-stroke-100595965",false,"NCT07039305","Physical Capacity Building for Chronic Stroke","Modified Cardiac Rehabilitation to Enhance Post-Stroke Physical and Psychosocial Function: Does Depression Limit the Response?","Inclusion Criteria:\n\n* Age 18-80\n* A diagnosis of stroke at least 6 months prior\n* Residual paresis in the lower extremity (Fugl-Meyer lower extremity \\[LE\\] motor score \\\u003C34)\n* Ability to walk without assistance and without an AFO during testing and training at speeds ranging from 0.2-1.0 m\u002Fs\n* Ability to follow instructions, complete cognitive testing and to communicate exertion, pain and distress\n* No antidepressant medications or no change in doses of psychotropic medication for at least 4 weeks prior to the study (6 weeks if newly initiated medication)\n* HDRS17 question #3 and PHQ-9 question #9 regarding suicide ≤ 2\n* Provision of informed consent.\n\nIn addition, depressed subjects will screen for probable major depressive disorder (Patient Health Questionnaire-9 ≥ 10) and be diagnosed using the Structured Clinical Interview for Depression (SCID) according to the DSM-5.\n\nExclusion Criteria:\n\n* Unable to ambulate at least 150 feet or experienced intermittent claudication while walking\n* Unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's\n* Dementia\n* Life expectancy \\\u003C1 yr\n* History of DVT or pulmonary embolism within 6 months\n* Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions\n* Severe hypertension with systolic \\>200 mmHg and diastolic \\>110 mmHg at rest\n* Attempt of suicide in the last 2 years or suicidal risk assessed by depression screening\n* Current enrollment in a rehabilitation trial to enhance motor, cognitive and or psychosocial recovery\n* Severe cognitive impairment (MoCA score ≤15)\n* Moderate to severe neglect that precludes cognitive testing\n\nFor brain stimulation procedures only:\n\n* Electronic or metallic implants\n* History of seizures\n* Women of child bearing potential","ALL","18 Years","80 Years",{"count":65,"type":66},76,"ESTIMATED","INTERVENTIONAL",[69],"NA","Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery. Investigators believe that individuals who have had a stroke need to be treated similarly. Investigators will study the effects of a comprehensive modified cardiac rehabilitation program to determine if it can improve some of the physical and psychosocial problems common in survivors of stroke with and without depression.",[72,73],"Stroke","Post-stroke Depression",[75,76,72,77],"Depression","Exercise","Stroke Recovery","2025-12-01",{"date":80,"type":81},"2025-12-08","ACTUAL",{"date":83,"type":81},"2025-08-05",{"date":85,"type":66},"2029-08",{"name":5,"class":6},1]