[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605318":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":149,"collaborators":26,"id":151,"slug":152,"hasResults":153,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":153,"sex":159,"minAge":160,"maxAge":26,"enrollmentInfo":161,"targetDuration":26,"studyType":164,"phases":165,"briefSummary":167,"conditions":168,"keywords":171,"overallStatus":177,"whyStopped":26,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":187},{"fullName":5,"class":6},"Biogem s.c.ar.l.","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Arm","EXPERIMENTAL","Combined aerobic (walking) and resistance exercise group. Patients randomised to this group will receive a structured exercise program to be performed at least thrice a week for 26 weeks. The physical exercise intervention will be managed and supervised by the personnel of the centres participating in the trial. The training program will be personalised according to the patient's baseline functional capacity assessed by the 6-minute walking test (6MWT). The aerobic exercise will include seven bouts of 2-minute walking separated by 1-minute seated rest (up to 2-minute periods of resting in the Very Low category) at a slow to moderate speed. A smartphone application designed to guide the weekly increase in speed will also record the number of training sessions performed. An instructor will specifically instruct all patients to walk in rhythm with the metronome. The goal intensity for each session is 9-10 (light-fairly light) on the 20-point Borg RPE. The number of steps per session will",[13],"Behavioral: Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo comparator","PLACEBO_COMPARATOR","The control group will undergo standard nephrology care that include optimization of medical therapy, nutritional advices, best dialysis practice.",[19],"Other: Control (Standard treatment)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Exercise","Patients will undergo a home-based low-intensity interval multi component exercise program including aerobic and strengthening exercise",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Control (Standard treatment)","Patients will be treated with standard therapy based on their CKD stage",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Crmine Zoccali","CONTACT","+393407354062","carmine.zoccali@icloud.com",[38,54,77,94,113,134],{"facility":39,"status":26,"city":40,"state":26,"zip":26,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Assistance Publique - Hôpitaux de Paris (AP-HP), Division of Geriatry","Paris","France","FR",{"type":44,"coordinates":45},"Point",[46,47],2.3488,48.85341,{"lat":47,"lon":46},[50],{"name":51,"role":34,"phone":52,"phoneExt":26,"email":53},"Marion Pépin","+33699426061","marion.pepin@aphp.fr",{"facility":55,"status":26,"city":56,"state":26,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Biogem","Ariano Irpino","83031","Italy","IT",{"type":44,"coordinates":61},[62,63],15.10625,41.16024,{"lat":63,"lon":62},[66,68,71,73,75],{"name":67,"role":34,"phone":35,"phoneExt":26,"email":36},"Carminre Zoccali",{"name":69,"role":70,"phone":26,"phoneExt":26,"email":26},"Ilaria Guerriero","SUB_INVESTIGATOR",{"name":72,"role":70,"phone":26,"phoneExt":26,"email":26},"Giovambattista Capasso",{"name":74,"role":70,"phone":26,"phoneExt":26,"email":26},"Fabio Manfredini",{"name":76,"role":70,"phone":26,"phoneExt":26,"email":26},"Nicola Lamberti",{"facility":78,"status":26,"city":79,"state":26,"zip":26,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Lithuanian University of Health Sciences","Kaunas","Lithuania","LT",{"type":44,"coordinates":83},[84,85],23.90909,54.90156,{"lat":85,"lon":84},[88,92],{"name":89,"role":34,"phone":90,"phoneExt":26,"email":91},"Inga Bumblyte","+37037326189","ingabumblyte@gmail.com",{"name":93,"role":70,"phone":26,"phoneExt":26,"email":26},"Justina Kurganaite",{"facility":95,"status":26,"city":96,"state":26,"zip":26,"country":97,"countryCode":98,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"University Medical Center Groningen, Department of Nephrology","Groningen","Netherlands","NL",{"type":44,"coordinates":100},[101,102],6.56667,53.21917,{"lat":102,"lon":101},[105,109,111],{"name":106,"role":34,"phone":107,"phoneExt":26,"email":108},"Casper F.M. Franssen","+31631673051","c.f.m.franssen@umcg.nl",{"name":110,"role":70,"phone":26,"phoneExt":26,"email":26},"Manuela Ypes Calderon",{"name":112,"role":70,"phone":26,"phoneExt":26,"email":26},"Wilma Veldman",{"facility":114,"status":26,"city":115,"state":26,"zip":26,"country":116,"countryCode":117,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Medical University of Warsaw, Department of Nephrology, Dialysis and Internal Medicine","Warsaw","Poland","PL",{"type":44,"coordinates":119},[120,121],21.01178,52.22977,{"lat":121,"lon":120},[124,128,130,132],{"name":125,"role":34,"phone":126,"phoneExt":26,"email":127},"Jolanta Malyszko","+48225992660","jolmal@poczta.onet.pl",{"name":129,"role":70,"phone":26,"phoneExt":26,"email":26},"Alexandra Golenia",{"name":131,"role":70,"phone":26,"phoneExt":26,"email":26},"Klaudia Prusinowska",{"name":133,"role":70,"phone":26,"phoneExt":26,"email":26},"Dominika Kurzawa",{"facility":135,"status":26,"city":136,"state":26,"zip":26,"country":137,"countryCode":138,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"University of Zurich","Zurich","Switzerland","CH",{"type":44,"coordinates":140},[141,142],8.55,47.36667,{"lat":142,"lon":141},[145],{"name":146,"role":34,"phone":147,"phoneExt":26,"email":148},"Carsten A. Wagner","+41763770238","wagnerca@access.uzh.ch",{"type":150,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100605318","physical-exercise-to-prevent-mild-cognitive-impairment-in-patients-with-kidney-disfunctions-100605318",false,"NCT07160959","Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions","Physical Exercise to Prevent Mild-cognitive Impairment Progression in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients","Exprecoimp-CKD","Inclusion Criteria:\n\n* CKD at KDOQI stage 4-5\n* concomitant MCI (MOCA - MMSE (17 \\\u003C MoCA \\\u003C 26) or (16 \\\u003C MMSE \\\u003C 24)\n\nExclusion Criteria:\n\n* Absolute contraindication to exercise training (e.g. unstable angina, major amputation, severe heart failure, etc.)\n* Known life expectancy \\\u003C 6-month\n* Uncorrected anemia (Hb \\\u003C9 g\u002Fdl)\n* Non-provision of informed consent","ALL","18 Years",{"count":162,"type":163},124,"ESTIMATED","INTERVENTIONAL",[166],"NA","This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.",[169,170],"Chronic Kidney Disease (Stages 4 and 5)","Mild Cognitive Impairment (MCI)",[172,173,174,175,176],"Chronic Kidney Disease (CKD)","stage G4-5 (CKD G4-5)","dialysis","physical exercise","cognitive function","NOT_YET_RECRUITING","2025-08-29",{"date":180,"type":181},"2025-09-08","ACTUAL",{"date":183,"type":163},"2026-01-01",{"date":185,"type":163},"2030-04-30",{"name":5,"class":6},6]