[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616802":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":29,"locations":38,"responsibleParty":117,"collaborators":19,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":121,"sex":127,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":19,"studyType":133,"phases":134,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":144,"whyStopped":19,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"University Hospital, Bordeaux","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ITP group","EXPERIMENTAL","Children, adolescents and young adults aged 8 to 25 followed for ITPc (N=53)",[13],"Other: IPT-CPET",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"IPT-CPET","Patients with ITP will undergo standard care, medical examination, cardiopulmonary exercise test (CPET), muscular strength and physical activity tests, and validated questionnaires of health-related and disease-related quality of life, mental health, and physical activity",[9],null,[21,24,26],{"name":22,"affiliation":5,"role":23},"Pascal AMEDRO, MD,PhD","STUDY_DIRECTOR",{"name":25,"affiliation":5,"role":23},"Nathalie ALADJIDI, MD",{"name":27,"affiliation":5,"role":28},"Marion AUDIE, MD","PRINCIPAL_INVESTIGATOR",[30,35],{"name":27,"role":31,"phone":32,"phoneExt":33,"email":34},"CONTACT","+330557656465","+33","marion.audie@chu-bordeaux.fr",{"name":25,"role":31,"phone":36,"phoneExt":33,"email":37},"+33 05 57 82 02 61","nathalie.aladjidi@chu-bordeaux.fr",[39,60,73,87,102],{"facility":40,"status":19,"city":41,"state":42,"zip":43,"country":42,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Armand de Villeneuve Hospital - Montpellier University Hospital","Montpellier","France","34295","FR",{"type":46,"coordinates":47},"Point",[48,49],3.87635,43.61093,{"lat":49,"lon":48},[52,56],{"name":53,"role":31,"phone":54,"phoneExt":33,"email":55},"Sophie GUILLAUMONT, MD","+33 0467336639","s-guillaumont@chu-montpellier.fr",{"name":57,"role":31,"phone":58,"phoneExt":33,"email":59},"Éric JEZIORSKI, MD,PhD","+33 0467336603","e-jeziorski@chu-montpellier.fr",{"facility":61,"status":19,"city":62,"state":42,"zip":63,"country":42,"countryCode":44,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Institut Saint-Pierre","Palavas-les-Flots","34250",{"type":46,"coordinates":65},[66,67],3.93043,43.52974,{"lat":67,"lon":66},[70],{"name":53,"role":31,"phone":71,"phoneExt":33,"email":72},"+33 0467077552","guillaumont.s@institut-st-pierre.fr",{"facility":74,"status":19,"city":75,"state":42,"zip":76,"country":42,"countryCode":44,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Armand Trousseau Hospital - AP-HP","Paris","75012",{"type":46,"coordinates":78},[79,80],2.3488,48.85341,{"lat":80,"lon":79},[83],{"name":84,"role":31,"phone":85,"phoneExt":33,"email":86},"Sébastien HERITIER, MD,PhD","+33 0171738717","sebastien.heritier@aphp.fr",{"facility":88,"status":19,"city":75,"state":42,"zip":89,"country":42,"countryCode":44,"cosmosGeoPoint":90,"geoPoint":92,"contacts":93},"Robert Debré Hospital - APHP","75019",{"type":46,"coordinates":91},[79,80],{"lat":80,"lon":79},[94,98],{"name":95,"role":31,"phone":96,"phoneExt":33,"email":97},"Christophe DELCLAUX, MD,PhD","+33 0140034190","christophe.delclaux@aphp.fr",{"name":99,"role":31,"phone":100,"phoneExt":33,"email":101},"Thierry LEBLANC, Md,PhD","+33 0140034185","thierry.leblanc@aphp.fr",{"facility":103,"status":19,"city":104,"state":42,"zip":105,"country":42,"countryCode":44,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Pellegrin Hospital - Bordeaux University Hospital","Talence","33400",{"type":46,"coordinates":107},[108,109],-0.58915,44.80849,{"lat":109,"lon":108},[112,114],{"name":27,"role":31,"phone":113,"phoneExt":33,"email":34},"+33 0557656465",{"name":115,"role":31,"phone":116,"phoneExt":33,"email":37},"Nathalie ALADJIDI Nathalie, MD","+33 0557820261",{"type":118,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100616802","physical-fitness-of-children-adolescents-and-young-adults-with-immune-thrombocytopenic-purpura-100616802",false,"NCT07310342","Physical Fitness of Children, Adolescents and Young Adults With Immune Thrombocytopenic Purpura","Physical Fitness of Children, Adolescents and Young Adults With Immune Thrombocytopenic Purpura: a Prospective, Multicentre, Controlled National Study","ITP-CPET","Inclusion Criteria:\n\n* Children, adolescents and young adults aged 8 to 25 followed for ITPc\n* Patient referred as part of routine care by a CEREVANCE network expert physician to an exercise physiology laboratory for fitness assessment\n\nExclusion Criteria:\n\n* Presence of at least one contraindication to performing an exercise test\n\n  * Acute anemia \\\u003C 9g or poorly tolerated chronic anemia, fever, uncontrolled asthma, respiratory failure, acute myocarditis or pericarditis, uncontrolled arrhythmias causing symptoms or hemodynamic disturbance, uncontrolled heart failure, acute pulmonary embolism or pulmonary infarction,\n  * Patients with mental impairment leading to an inability to cooperate, as assessed by the physician during the history,\n  * Clinical examination abnormalities (heart murmur, rhythm disorders).\n* Opposition to participation expressed by the parent(s) or legal guardian(s) for minors (\\\u003C18 years) or by the patient.\n* Absence of social security","ALL","8 Years","25 Years",{"count":131,"type":132},53,"ESTIMATED","INTERVENTIONAL",[135],"NA","Patients with chronic immune thrombocytopenic purpura (ITP) live with an anxiety-inducing risk of haemorrhage that is unpredictable over several months or years.\n\nThey also rate fatigue as one of the most frequent (48%) and most severe (73%) disabling symptoms, which contributes to a reduced quality of life \\[Cooper, 2021\\].\n\nIn this autoimmune disease targeting platelets, fatigue could be mediated by platelet and immunological abnormalities, and\u002For promoted by psychobehavioural determinants that are poorly understood in this chronic disease.\n\nSince 1980, the World Health Organisation has stated that functional capacity assessments best reflect the impact of chronic diseases on quality of life, with fatigue playing an important role. The association between fatigue and aerobic physical capacity, determined by maximum oxygen consumption (VO2max), has been demonstrated in several pathologies. It is often associated with the vicious circle of deconditioning, where the impact of the disease on cardiac, muscular and respiratory functions is intertwined with inactive or sedentary behaviours.\n\nAt the end of this vicious circle, adults have been shown to have an increased cardiovascular risk and a high prevalence of anxiety and depression syndromes.\n\nVO2max measured by cardiopulmonary exercise testing (CPET) is increasingly used in monitoring, as recommended by the French Society of Cardiology \\[Marcadet, 2018;Marcadet, 2019\\]. Our team (Amedro et al.) has set up a research programme on aerobic physical capacity and deconditioning to exercise in chronic childhood diseases and has just published the reference values for exercise tests in healthy paediatric populations, enabling the interpretation of VO2max results in sick children \\[Gavotto,2023\\].\n\nHowever, it has been demonstrated that the VO₂ plateau is not predominantly reached in healthy adults and is rarely reached (\\\u003C25%) in healthy children. \\[Armstrong, 1996 ; Åstrand, 1952 ; Rowland, 1992\\].\n\nThus, the highest oxygen consumption measurement (VO2pic) is often used instead of VO2max to define aerobic capacity. We will therefore use the concepts of VO2max and VO2pic in this study.\n\nThe first population studied by our team was children with congenital heart disease, who showed a significant reduction in their VO2max \\[Amedro, 2018\\]. Based on these results, a functional rehabilitation programme (QUALIREHAB) was set up and evaluated in a randomised controlled clinical trial \\[Amedro, 2019\\] . The data demonstrate its positive impact not only on VO2max, but also on quality of life. Aerobic physical capacity was assessed in chronic paediatric diseases without direct cardiac involvement.\n\nWe have also shown that VO2max declines more rapidly over time in children, adolescents and young adults who have survived childhood cancer \\[Gavotto, 2023\\] or in children with asthma \\[Moreau, 2023\\].\n\nTo date, no prospective controlled studies have reported on the level of aerobic physical capacity in children, adolescents and young adults with cITP.\n\nWe therefore hypothesise that fatigue in patients monitored for cITP could be correlated with a decrease in their aerobic physical capacity, causing these patients to enter a 'vicious cycle of deconditioning'. If this hypothesis is verified, an exercise rehabilitation programme could have a positive impact on quality of life, physical health and mental health",[138],"Immune Thrombocytopenic Purpura",[140,141,142,143],"Immune thrombocytopenic purpura (ITP)","Fatigue","Deconditioning","functional rehabilitation","NOT_YET_RECRUITING","2025-12-16",{"date":147,"type":148},"2025-12-30","ACTUAL",{"date":150,"type":132},"2025-12-15",{"date":152,"type":132},"2026-12-22",{"name":5,"class":6},5]