[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534544":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":28,"locations":37,"responsibleParty":55,"collaborators":58,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":18,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":18,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":18,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Rigshospitalet, Denmark","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Inactivity","EXPERIMENTAL","Inactivity will be implemented as cessation of active commuting and all other structured exercise. Furthermore, steps will be reduced to a maximum of 1500 steps\u002Fday.",[13],"Behavioral: Inactivity",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Participants will be instructed to maintain habitual physical activity and dietary habits.",null,[20],{"type":21,"name":9,"description":11,"armGroupLabels":22,"otherNames":18},"BEHAVIORAL",[9],[24],{"name":25,"affiliation":26,"role":27},"Grit Elster Legård, MD, PhD","Centre for Physical Activity Research, Rigshospitalet","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Inge Holm","CONTACT","+45 35 45 76 41","inge.holm@regionh.dk",{"name":35,"role":31,"phone":32,"phoneExt":18,"email":36},"Bente K Pedersen, Dr Med","Bente.Klarlund.Pedersen@regionh.dk",[38],{"facility":39,"status":40,"city":41,"state":18,"zip":18,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Copenhagen University Hospital","RECRUITING","Copenhagen","Denmark","DK",{"type":45,"coordinates":46},"Point",[47,48],12.56553,55.67594,{"lat":48,"lon":47},[51],{"name":52,"role":31,"phone":53,"phoneExt":18,"email":54},"Grit E Legård","+45 35457641","grit.elster.legaard@regionh.dk",{"type":27,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Grit Elster Legård","Primary Investigator",[59,62],{"name":60,"class":61},"Novo Nordisk A\u002FS","INDUSTRY",{"name":63,"class":61},"TrygFonden, Denmark","100534544","physical-inactivity-and-appetite-regulation-100534544",false,"NCT06240208","Physical Inactivity and Appetite Regulation","The Effects of Inactivity on GLP-1 Stimulated Appetite Regulation in Healthy Normal Weight Males: A Randomised, Parallel Group Study","Inclusion Criteria:\n\n1. Male\n2. Age ≥ 40 years and ≤ 55 years\n3. Body mass index (BMI) \\> 20 and \\\u003C 25 kg\u002Fm2\n4. Physical activity level should as a minimum include: Active commuting by biking a minimum of 10 km, four days per week or an equivalent amount of other physical activity four days per week.\n5. Healthy (based on self-reporting, pre-study medical examination and biochemical screening)\n6. Can adhere to two weeks of inactivity (refrain from running, cycling and all other exercise while reducing steps to max. 1500 pr. day)\n7. Caucasian\n8. No change in body weight \\> 5 kg within the last 6 months\n9. Eats breakfast and lunch daily\n10. Does not follow specific dietary restrictions\n11. No disliking of spaghetti bolognese\n12. No diagnosis of psychiatric disorder or treatment with anti-depressant or anti-psychotic medication\n13. No history of suicidal behavior or ideations.\n14. No previous surgical treatment for obesity\n15. No cardiovascular disease\n16. No rheumatologic disease\n17. No metabolic\u002Fendocrine disease\n18. No liver disease (ASAT or ALAT \\>2x upper normal range)\n19. No other chronic disease\n20. No elite sports\n21. No frequent or chronic use of medications affecting bodyweight, physical performance, or inflammation (NSAIDS, DMARDS, corticosteroids)\n22. No current infection\n23. No history of cancer\n24. No anemia (hematocrit \\\u003C33%)\n25. No smoking\n26. No participation in other research intervention studies\n\nExclusion Criteria:\n\n1. Clinical or biochemical signs of disease\n2. HbA1c \\> 39 mmol\u002Fmol\n3. Unable to allocate the needed time to fulfill the intervention\n4. Language barrier, mental incapacity, unwillingness, or inability to understand and be able to complete the interventions",true,"MALE","40 Years","55 Years",{"count":76,"type":77},40,"ESTIMATED","INTERVENTIONAL",[80],"NA","The goal of this parallel-group, two-arm, assessor-blinded, randomised clinical trial is to investigate the effects of reducing physical activity on food intake and satiety in physically active and healthy males, 40-55 years of age.\n\nThe main questions it aims to answer are:\n\n* Does physical inactivity affect GLP-1 stimulated food intake?\n* Does physical inactivity affect food preferences, satiety and other mechanisms supporting appetite regulation?\n\nParticipants will be randomised (1:1) to two weeks of either no intervention (control group) or inactivity. Inactivity will be implemented as cessation of active commuting and all other structured exercise. Furthermore, steps will be reduced to a maximum of 1500 steps\u002Fday.\n\nResearchers will compare the inactivity group to the control group to see if physical inactivity impairs appetite regulation.",[83],"Overweight","2026-03-25",{"date":86,"type":87},"2026-03-30","ACTUAL",{"date":89,"type":87},"2024-03-01",{"date":91,"type":77},"2026-12",{"name":5,"class":6},1]