[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100169205":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":19,"centralContacts":23,"locations":7,"responsibleParty":28,"collaborators":7,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":7,"eligibilityCriteria":36,"healthyVolunteers":32,"sex":37,"minAge":38,"maxAge":7,"enrollmentInfo":7,"targetDuration":7,"studyType":39,"phases":7,"briefSummary":40,"conditions":41,"keywords":43,"overallStatus":51,"whyStopped":7,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":7,"completionDateStruct":7,"leadSponsor":56,"locationsCount":7},{"fullName":5,"class":6},"Amicus Therapeutics","INDUSTRY",null,[9,15],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DRUG","migalastat HCl 150 mg","150 mg capsule",[14],"AT1001, migalastat",{"type":10,"name":16,"description":17,"armGroupLabels":7,"otherNames":18},"migalastat HCl 20 mg","20 mg dispersible tablets; dosing will be based on body weight",[14],[20],{"name":21,"affiliation":5,"role":22},"Medical Monitor, Clinical Research","STUDY_DIRECTOR",[24],{"name":25,"role":26,"phone":7,"phoneExt":7,"email":27},"Amicus Therapeutics Patient Advocacy","CONTACT","patientadvocacy@amicusrx.com",{"type":29,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100169205","physician-initiated-expanded-access-request-for-migalastat-in-individual-patients-with-fabry-disease-100169205",false,"NCT01476163","Physician Initiated Expanded Access Request for Migalastat in Individual Patients With Fabry Disease","Physician Initiated Expanded Access Request for Treatment Use of Migalastat Hydrochloride (AT1001), an Investigational Treatment for Individual Patients With Fabry Disease (AT1001-188)","Inclusion Criteria:\n\n* Confirmed GLA mutation predicted to be responsive migalastat in the human embryonic kidney (HEK-293) cell-based assay\n* At least 2 years of age\n* Strong clinical indication for treatment of Fabry disease\n* No other treatment option including either unsuitable for ERT or unable to access ERT\n* Appropriate female and male contraception\n* Willing to receive treatment with migalastat HCl via this program including having signed an authorization for sharing clinical data\n\nExclusion Criteria:\n\n* Scheduled for renal or other organ transplant or replacement therapy\n* Receiving GLYSET® (miglitol), ZAVESCA® (miglustat) or enzyme replacement therapy FABRAZYME® (agalsidase beta), REPLAGAL™ (agalsidase alpha), or Elfabrio® (pegunigalsidase alfa)\n* Contraindication to migalastat, i.e., sensitivity to other iminosugar such as miglustat, miglitol\n* Treated with another investigational drug within 30 days of start of migalastat HCl treatment\n* Unable to comply with study requirements or deemed otherwise unsuitable for study entry in the opinion of the investigator.","ALL","2 Years","EXPANDED_ACCESS","This program allows physicians to request permission from Amicus Therapeutics (Amicus) for treatment access to migalastat hydrochloride (HCl) for specific patients with Fabry disease. Treatment is open label.",[42],"Fabry Disease",[44,45,46,47,48,49,50],"AT1001","migalastat","Fabry disease","Fabry","Amicus","lysosomal disease","lysosomal disorder","AVAILABLE","2025-07-01",{"date":54,"type":55},"2025-07-03","ACTUAL",{"name":5,"class":6}]