[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100418646":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":25,"locations":30,"responsibleParty":42,"collaborators":19,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":19,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":19,"enrollmentInfo":54,"targetDuration":19,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":70,"whyStopped":19,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Khon Kaen University","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Healthy pregnant women","Optical coherence tomography and Optical coherence tomography angiography using Optovue® were performed in each trimester and at 6 weeks after childbirth.",[12],"Device: Optical coherence tomography and optical coherence tomography angiography (Optovue®)",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Optical coherence tomography and optical coherence tomography angiography (Optovue®)","Optical coherence tomography and optical coherence tomography angiography (Optovue®) were performed in each trimesters and at 6 weeks after childbirth.\n\n1. st trimester : gestational age 8-12 weeks\n2. nd trimester : gestational age 24-28 weeks\n3. rd trimester : gestational age 34-38 weeks",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Suthasinee Sinawat, MD","KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":29},"CONTACT","+66 81 5454594","ssuthasinee@kku.ac.th",[31],{"facility":5,"status":19,"city":32,"state":19,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":19},"Khon Kaen","40002","Thailand","TH",{"type":37,"coordinates":38},"Point",[39,40],102.833,16.44671,{"lat":40,"lon":39},{"type":24,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Suthasinee Sinawat","Associate Professor","100418646","physiologic-change-of-posterior-ocular-segment-during-pregnancy-100418646",false,"NCT04731415","Physiologic Change of Posterior Ocular Segment During Pregnancy","Inclusion Criteria:\n\n* Healthy pregnant women\n* Age \\> 18 years\n* Gestational age \\\u003C 12 weeks\n* Written informed consent\n\nExclusion Criteria:\n\n* High risk pregnancy such as multifetal pregnancy and preeclampsia\n* History of vitreoretinal diseases such as retinal vasculitis\n* History of intraocular laser treatments or intraocular surgeries\n* History of systemic diseases such as diabetes mellitus and thyroid disease\n* Refractive error; spherical equivalence \\> 4 diopters\n* Clear ocular media\n* Could not be taken the images by non-dilated pupil\n\nWithdrawal Criteria:\n\n* Preterm labor; gestational age \\\u003C 34 weeks\n* Multifetal pregnancy was demonstrated by ultrasound\n* Severe labor and delivery complications such as\n* Severe postpartum complications such as postpartum bleeding\n* Taking hormone during the follow-up period",true,"FEMALE","18 Years",{"count":55,"type":56},69,"ESTIMATED","INTERVENTIONAL",[59],"NA","Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progesterone. Blood volume starts to increase in the first gestational period and reaches a peak in the third trimester.\n\nThe physiologic ocular changes during pregnancy are mainly the result of hormonal and blood volume increase, and then are usually marked in the third trimester.",[62],"Retinal Vascular",[64,65,66,67,68,69],"Retinal vascular density","Optical coherence tomography angiography","Choroidal thickness","Retinal nerve fiber layer thickness","Optic nerve head","Optical coherence tomography","NOT_YET_RECRUITING","2021-06-29",{"date":73,"type":74},"2021-06-30","ACTUAL",{"date":76,"type":56},"2021-07-01",{"date":78,"type":56},"2026-06-30",{"name":5,"class":6},1]