[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570097":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":52,"collaborators":20,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":20,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":20,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"CHFO group","EXPERIMENTAL","After checking the availability of the CHFO machine (MetaNeb® system), the inclusion and non-inclusion criteria, the patient is included. The following procedures are performed:\n\n1. installation of an EIT belt in the 4th or 5th intercostal space (Pulmovista® 500, Dräger);\n2. continuous recording of digital and analogic data after collecting initial data from the patient within 10 minutes before CHFO treatment, successive 10-minutes CHFO were performed. At the end of the treatment, all the data is collected.",[13],"Device: High-Frequency Oscillatory Ventilation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","High-Frequency Oscillatory Ventilation","Administer 10 minutes of high-frequency oscillatory ventilation in awake ICU patients.",[9],null,[22,28],{"name":23,"role":24,"phone":25,"phoneExt":26,"email":27},"Shengyu Hao, PhD","CONTACT","02164041990","13671","janet9yu@163.com",{"name":29,"role":24,"phone":25,"phoneExt":20,"email":30},"Yuxian Wang, B.S.","Wang.yuxian@zs-hospital.sh.cn",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Zhongshan Hospital, Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200030","China","CN",{"type":41,"coordinates":42},"Point",[43,44],121.45806,31.22222,{"lat":44,"lon":43},[47],{"name":48,"role":24,"phone":49,"phoneExt":50,"email":51},"Ming Zhong, PhD","02164001990","114","zhong.ming@zs-hospital.sh.cn",{"type":53,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100570097","physiological-effects-and-safety-of-continuous-high-frequency-oscillatory-ventilation-in-icu-patients-100570097",false,"NCT06702813","Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in ICU Patients","Inclusion Criteria:\n\n* Patients older than 18 and younger than 90 years;\n* Admitted to the ICU after December 1, 2024, who are alert, with a GCS of 15, normal comprehension, and able to communicate clearly through speech or writing.\n* Patients with atelectasis, who are receiving oxygen therapy, high-flow oxygen, or are on a ventilator via tracheostomy.\n* Signed informed consent for MetaNeb treatment.\n\nExclusion Criteria:\n\n* Refusal to participate in the proposed study.\n* Age \\\u003C 10 years;\n* Pregnancy;\n* Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood volume, for a target mean blood pressure between 65 and 75 mmHg.\n* Participation in another trial within 30 days prior to meeting eligibility criteria;\n* Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation;\n* Pneumothorax. With a clear tracheoesophageal fistula","ALL","18 Months","80 Years",{"count":64,"type":65},45,"ESTIMATED","INTERVENTIONAL",[68],"NA","Atelectasis, hypoxemia, and ineffective sputum clearance are common problems in ICU patients. Continuous High-Frequency Oscillation (CHFO) is often considered to have a protective effect on the lungs. CHFO provides effective gas exchange at supraphysiological frequencies while minimizing pressure fluctuations, producing tidal volumes smaller than dead space, and adjusting around a continuously expanding pressure to optimize end-expiratory lung volume (EELV), thereby improving lung function by achieving and maintaining lung recruitment. However, the physiological effects and safety of CHFO in awake critically ill patients are still lacking relevant research. The objective of this study is to evaluate the comfort, safety, and efficacy of CHFO in awake critically ill patients.",[71,72,73],"Atelectasis, Postoperative","Hypoxia","Critical Illness",[75,76,77],"HFOV","EIT","atelectasis","2024-11-21",{"date":80,"type":81},"2024-11-25","ACTUAL",{"date":83,"type":65},"2024-11-19",{"date":85,"type":65},"2025-12-01",{"name":5,"class":6},1]