[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569622":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":49,"collaborators":53,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":18,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":18,"enrollmentInfo":64,"targetDuration":18,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":33,"whyStopped":18,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention group","EXPERIMENTAL","EIT-guided Phigh settings during APRV",[13],"Device: EIT-guided Phigh settings during APRV",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Pplat-guided Phigh settings during APRV",null,[20],{"type":21,"name":11,"description":22,"armGroupLabels":23,"otherNames":18},"DEVICE","The Phigh level selected for the patients in the Intervention group was the intercept point of cumulated collapse and overdistension percentage curves, providing the best compromise between collapsed and overdistended lung.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"jing Xiao Zou","CONTACT","+862785351606","249126734@qq.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Wuhan Union hospital","RECRUITING","Wuhan","Hubei","237000","China","CN",{"type":40,"coordinates":41},"Point",[42,43],114.26667,30.58333,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":48,"phoneExt":18,"email":29},"xiaojing Zou, MD","13995518630",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","XiaoJing Zou,MD","Clinical Professor",[54],{"name":5,"class":6},"100569622","physiological-effects-of-lung-impedance-tomography-guided-and-plat-pressure-guided-phigh-during-aprv-in-patients-with-ards-100569622",false,"NCT06696638","Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS","Physiological Effects of Lung Impedance Tomography-guided and Plat Pressure-guided Phigh During Airway Pressure Release Ventilation in Patients With Acute Respiratory Distress Syndrome","Inclusion Criteria:\n\n* Diagnosed with ARDS according to the 2023 global new definition of ARDS.\n* Age ≥ 18 years.\n\nExclusion Criteria:\n\n* Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.\n* Pulmonary interstitial disease.\n* Uncorrected shock of various types.\n* Intracranial hypertension.\n* Pregnant and postpartum women.","ALL","18 Years",{"count":65,"type":66},26,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.",[72],"ARDS: Acute Respiratory Distress Syndrome",[74,75,76,77],"ARDS","APRV","EIT","Phigh","2025-01-03",{"date":80,"type":81},"2025-01-06","ACTUAL",{"date":83,"type":66},"2025-01-01",{"date":85,"type":66},"2026-12-31",{"name":51,"class":6},1]