[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623221":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":38,"locations":44,"responsibleParty":63,"collaborators":29,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":29,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":91,"whyStopped":29,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Universidad Europea de Madrid","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental: Sustained Pressure","EXPERIMENTAL","Participants receive a graded manual pressure protocol applied as sustained pressure at a single point over the upper trapezius muscle (0, 25, 50, 75 and 90% of individual PPT, 2 minutes each level, randomized order).",[13],"Other: Graded Sustained Pressure",{"label":15,"type":10,"description":16,"interventionNames":17},"Experimental: Longitudinal Kneading","Participants receive the same graded pressure protocol applied as longitudinal kneading over a defined area of the upper trapezius muscle (0, 25, 50, 75 and 90% of individual PPT, 2 minutes each level, randomized order).",[18],"Other: \"Manual Pressure Protocol\"",{"label":20,"type":10,"description":21,"interventionNames":22},"Experimental: Manual Therapy Protocols","Participants receive three standardized manual therapy protocols with increasing pressure in three separate sessions, with randomized order: (1) manual lymphatic drainage (\\~40 mmHg, approximately 40 minutes), (2) light-pressure massage (0.5-0.8 N\u002Fcm², 20-30 minutes) and (3) moderate-pressure massage (2-3 N\u002Fcm², 20 minutes), targeting the upper trapezius and related regions.",[23],"Other: Manual Therapy Protocols (DLM, light and moderate-pressure massage)",[25,30,34],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"\"Manual Pressure Protocol\"","Manual pressure is applied over the upper trapezius muscle using five individualized pressure levels (0, 25, 50, 75 and 90% of the pressure pain threshold). Each level is applied for 2 minutes in a single experimental session, with randomized order and rest periods between applications. In the Sustained Pressure arm, pressure is maintained at a single point. In the Longitudinal Kneading arm, the same pressure levels are distributed along a predefined area using a kneading technique.",[15],null,{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Manual Therapy Protocols (DLM, light and moderate-pressure massage)","Three standardized manual therapy protocols targeting the upper trapezius and related regions are applied in separate sessions with at least one day between them and randomized order: (1) manual lymphatic drainage (approx. 40 minutes at \\~40 mmHg), (2) light-pressure massage (0.5-0.8 N\u002Fcm², 20-30 minutes) and (3) moderate-pressure massage (2-3 N\u002Fcm², 20 minutes). Pressure is monitored continuously with a hand-worn pressure sensor.",[20],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":29},"Graded Sustained Pressure","Manual pressure applied over the upper trapezius using five individualized pressure levels (0, 25, 50, 75 and 95% of the pressure pain threshold) delivered as sustained pressure at a single point, 2 minutes per level in a single session, with randomized order and rest periods between applications.",[9],[39],{"name":40,"role":41,"phone":42,"phoneExt":29,"email":43},"Elena Velarde Dr, Byology Doctor","CONTACT","(34) 0912115268","elena.velarde@universidadeuropea.es",[45],{"facility":5,"status":29,"city":46,"state":29,"zip":29,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Villaviciosa de Odón","Spain","ES",{"type":50,"coordinates":51},"Point",[52,53],-3.9043,40.3581,{"lat":53,"lon":52},[56,58,61],{"name":57,"role":41,"phone":42,"phoneExt":29,"email":43},"Elena Velarde Dr",{"name":59,"role":60,"phone":29,"phoneExt":29,"email":29},"Raquel Pérez García","PRINCIPAL_INVESTIGATOR",{"name":62,"role":60,"phone":29,"phoneExt":29,"email":29},"Elena Velarde Fernández",{"type":60,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Vanesa Abuín","Principal Investigator","100623221","physiological-responses-to-manual-pressure-in-healthy-adults-100623221",false,"NCT07393815","\"Physiological Responses to Manual Pressure in Healthy Adults\"","Physiological Responses to Graded Manual Pressure in Healthy Adults: a Randomized Experimental Study on Autonomic, Hormonal, Sensory and Vascular Outcomes","VALIRAT1","Inclusion Criteria:\n\n* Age 18-65 years.\n* Healthy volunteers without diagnosed cardiovascular, neurological or severe musculoskeletal disorders.\n* No significant pain or pathology in the cervical, shoulder or upper back region that would interfere with pressure application.\n* Ability to understand the study procedures and to provide written informed consent.\n* Availability to attend the experimental session and the DEXA visit.\n\nExclusion Criteria:\n\n* History of major cardiovascular disease (e.g., ischemic heart disease, heart failure, clinically significant arrhythmias, uncontrolled hypertension, stroke or transient ischemic attack).\n* Neurological disorders affecting pain perception or autonomic function.\n* Acute or chronic musculoskeletal conditions in the cervical or shoulder region that contraindicate manual pressure on the upper trapezius.\n* Coagulation disorders or high-dose anticoagulant\u002Fantiplatelet therapy that increases bleeding risk.\n* Dermatologic conditions or skin lesions at sensor placement or pressure application sites.\n* Pregnancy or suspected pregnancy (due to DEXA scan).\n* Regular use of medications with a major impact on autonomic or cardiovascular responses (e.g., beta-blockers, antiarrhythmics) that cannot be paused according to medical judgement.\n* Substance abuse or acute alcohol\u002Fdrug intake in the 24 hours prior to the experimental session.\n* Any other condition that, in the opinion of the investigators, may compromise safety or compliance.",true,"ALL","18 Years","65 Years",{"count":79,"type":80},90,"ESTIMATED","INTERVENTIONAL",[83],"NA","This randomized experimental study will investigate how different intensities and application patterns of manual pressure applied to the upper trapezius muscle affect physiological responses in healthy adults. Participants will be randomly assigned to one of three groups: (A) graded sustained pressure at a single point over the upper trapezius, (B) graded longitudinal kneading over a defined area of the upper trapezius, or (C) three standardized manual therapy protocols with increasing pressure (manual lymphatic drainage, light-pressure massage and moderate-pressure massage).\n\nIn groups A and B, five individualized pressure levels (0, 25, 50, 75 and 95% of each participant's pressure pain threshold) will be delivered for 2 minutes each in a single session. In group C, each participant will receive the three manual therapy protocols in separate randomized sessions. Autonomic (heart rate and heart rate variability), hormonal (capillary cortisol and VEGF in group C), sensory (mechanical pain thresholds), hemodynamic (blood pressure) and, in group C, vascular (left common carotid artery ultrasound) responses will be recorded before and after the interventions. The study will provide dose-response and mechanistic information to inform safer and more individualized manual therapy protocols.",[86],"Healthy Participants",[88,89,90],"Autonomic Nervous System","Manual Therapy","Pain","NOT_YET_RECRUITING","2026-02-02",{"date":94,"type":95},"2026-02-06","ACTUAL",{"date":97,"type":80},"2026-03",{"date":99,"type":80},"2026-07",{"name":5,"class":6},1]