[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631655":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":36,"responsibleParty":54,"collaborators":20,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":20,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":20,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":39,"whyStopped":20,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Chongqing Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"High PEEP group","EXPERIMENTAL","PEEP is increased stepwise from 5 cmH₂O, with increments of 5 cmH₂O every 10-20 minutes until reaching 20 cmH₂O. Once PEEP reaches or exceeds 20 cmH₂O, increments are made every 3-5 minutes until the recruitment level is achieved (i.e., stepwise increases to 5, 10, 15, 20, 25, and 30 cmH₂O). Inspiratory pressure is adjusted simultaneously to maintain a constant pressure difference.",[13],"Procedure: high PEEP",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","high PEEP","First, PEEP was set at 5 cmH₂O, and inspiratory pressure was adjusted to achieve a target tidal volume of 6-8 mL\u002Fkg. Fraction of inspired oxygen (FiO₂) was titrated to maintain peripheral oxygen saturation (SpO₂) between 88% and 92%. Subsequently, PEEP was increased in 5 cmH₂O increments every 10-20 minutes from the initial value of 5 cmH₂O. Once PEEP reached 20 cmH₂O or above, increments were made every 3-5 minutes until the recruitment level was achieved (i.e., PEEP was increased stepwise from 5 to 10, 15, 20, 25, and 30 cmH₂O). Inspiratory pressure was adjusted concurrently to maintain a constant pressure difference. Throughout the procedure, physiological parameters-including respiratory rate, oxygenation, work of breathing, and others-were collected.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Jun Duan, MD","First Affiliated Hospital of Chongqing Medical University","PRINCIPAL_INVESTIGATOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Jun Duan","CONTACT","+86-89012680","duanjun412589@163.com",{"name":33,"role":29,"phone":34,"phoneExt":20,"email":35},"Yiwei Min","+8689012144","496996728@qq.com",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"The First Affiliated Hospital of Chongqing Medical University","RECRUITING","Chongqing","Chongqing Municipality","400016","China","CN",{"type":46,"coordinates":47},"Point",[48,49],106.55771,29.56026,{"lat":49,"lon":48},[52],{"name":28,"role":29,"phone":53,"phoneExt":20,"email":31},"86-023-89012680",{"type":25,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Duan jun","attending physician","100631655","physiological-study-of-high-peep-in-noninvasive-ventilation-100631655",false,"NCT07503509","Physiological Study of High PEEP in Noninvasive Ventilation","A Physiological Study of High PEEP During Noninvasive Ventilation in Patients With Hypoxemic Respiratory Failure","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. PaCO₂ ≤ 50 mmHg\n3. PaO₂\u002FFiO₂ ≤ 300 mmHg\n4. Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) -\n\nExclusion Criteria:\n\n1. Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic obstructive pulmonary disease (COPD) (COPD as a comorbidity may be included)\n2. Pneumothorax\n3. Patients who refuse to participate in this trial -","ALL","18 Years","100 Years",{"count":68,"type":69},50,"ESTIMATED","INTERVENTIONAL",[72],"NA","To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.",[75],"Respiratory Failure With Hypoxia",[77,78,79],"noninvasive ventilation","PEEP","respiratory failure","2026-03-25",{"date":82,"type":83},"2026-03-31","ACTUAL",{"date":85,"type":83},"2024-03-26",{"date":87,"type":69},"2026-06-30",{"name":5,"class":6},1]