[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548227":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":32,"responsibleParty":95,"collaborators":97,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":104,"sex":109,"minAge":110,"maxAge":10,"enrollmentInfo":111,"targetDuration":10,"studyType":114,"phases":10,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients",null,"Adult patients cared in one of the APHP hospital (Necker-Enfants Malades Hospital, Saint-Antoine Hospital, Pitié Salpêtrière Hospital and Beaujon Hospital) for whom a splenic intervention (spleno-pancreectomy, or a total or partial splenectomy) is planned as part of their treatment.",[13],"Other: Spleen, blood and plasma collection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Spleen, blood and plasma collection","Adult patients for whom a splenic intervention (spleno-pancreectomy, or a total or partial splenectomy) is planned as part of their care. One or more tubes of venous blood collected for the care will be recovered following the pre- or intra-operative assessment. Immediately following surgery, after careful examination by the pathologist in charge, the whole spleen or spleen fragments will be collected for further analysis. Whenever possible a catheter will be introduced in the splenic artery, the spleen will be flushed\u002Frinsed with 0.1 - 2 L of cold perfusion medium then transferred to the laboratory for ex-vivo perfusion. Before and at the end of the ex-vivo perfusion, splenic blood and spleen fragments will be collected and processed for further analyses.",[9],[20],{"name":21,"affiliation":5,"role":22},"Pierre Buffet, MD, PhD","PRINCIPAL_INVESTIGATOR",[24,27],{"name":21,"role":25,"phone":10,"phoneExt":10,"email":26},"CONTACT","pierre.buffet@aphp.fr",{"name":28,"role":25,"phone":29,"phoneExt":30,"email":31},"Hélène Morel","1 71 49 63 46","+33","helene.morel@aphp.fr",[33,56,70,81,89],{"facility":34,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Hôpital Beaujon","RECRUITING","Clichy","92110","France","FR",{"type":41,"coordinates":42},"Point",[43,44],2.30952,48.90018,{"lat":44,"lon":43},[47,52],{"name":48,"role":25,"phone":49,"phoneExt":50,"email":51},"Alain Sauvanet, MD, PhD","1 40 87 55 84","+ 33","alain.sauvanet@aphp.fr",{"name":53,"role":25,"phone":54,"phoneExt":50,"email":55},"Safi Dokmak","1 40 87 57 97","safi.dokmak@aphp.fr",{"facility":57,"status":35,"city":58,"state":10,"zip":59,"country":38,"countryCode":39,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Hôpital Saint Antoine","Paris","75012",{"type":41,"coordinates":61},[62,63],2.3488,48.85341,{"lat":63,"lon":62},[66],{"name":67,"role":25,"phone":68,"phoneExt":50,"email":69},"François Paye, MD, PhD","1 49 28 25 61","françois.paye@aphp.fr",{"facility":71,"status":35,"city":58,"state":10,"zip":72,"country":38,"countryCode":39,"cosmosGeoPoint":73,"geoPoint":75,"contacts":76},"Hôpital Pitié Salpêtrière","75013",{"type":41,"coordinates":74},[62,63],{"lat":63,"lon":62},[77],{"name":78,"role":25,"phone":79,"phoneExt":50,"email":80},"Christophe Trésallet, MD, PhD","1 42 17 66 03","christophe.tresallet@aphp.fr",{"facility":82,"status":35,"city":58,"state":10,"zip":83,"country":38,"countryCode":39,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Hôpital Necker-Enfants Malades","75015",{"type":41,"coordinates":85},[62,63],{"lat":63,"lon":62},[88],{"name":21,"role":25,"phone":10,"phoneExt":10,"email":26},{"facility":90,"status":91,"city":58,"state":10,"zip":83,"country":38,"countryCode":39,"cosmosGeoPoint":92,"geoPoint":94,"contacts":10},"Institut Pasteur","ACTIVE_NOT_RECRUITING",{"type":41,"coordinates":93},[62,63],{"lat":63,"lon":62},{"type":96,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[98,100],{"name":90,"class":99},"INDUSTRY",{"name":101,"class":6},"URC-CIC Paris Descartes Necker Cochin","100548227","physiology-and-pathologies-linked-to-human-splenic-function--direct-and-ex-vivo-perfusion-explorations-100548227",false,"NCT06418256","Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations","SPLEENVIVO","Inclusion Criteria:\n\n* Adult patients\n* Patient requiring left splenopancreectomy or planned splenectomy regardless of the method or indication\n\nExclusion Criteria:\n\n\\- The patient notified his doctor of his refusal to recover his spleen and blood volume","ALL","18 Years",{"count":112,"type":113},100,"ESTIMATED","OBSERVATIONAL","Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response in response to these anomalies, the spleen plays a central role in several diseases affecting blood cells, directly or indirectly. The analysis of the splenic clearance of abnormal cells during ex-vivo perfusions made it possible to clarify the pathogenesis of malaria and the role of the spleen in the adaptive immune response. The study's investigative team wishes to extend these explorations to other human diseases in which the spleen is involved, and to evaluate the preventive or curative potential of substances that can modify the perception of blood cells by the spleen (e.g. monoclonal antibodies directed against circulating cells, among other options).",[117],"Splenectomy",[119,120,121,122,123,124,125,126,127,128,129,130,131,132],"Spleen","Human splenic physiology","Splenic clearance","Splenic filtration mechanisms","Perfusion experiments","Role of the spleen in the adaptive immune response","Genetic spleen mechanisms","Blood","Erythrocytes","Leukocytes","Lymphocytes","Malaria","Sickle cell disease","Hereditary spherocytosis","2025-09-08",{"date":135,"type":136},"2025-09-15","ACTUAL",{"date":138,"type":136},"2016-10-16",{"date":140,"type":113},"2031-10-16",{"name":5,"class":6},5]