[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100253506":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":41,"collaborators":44,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Suez Canal University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Eclampsia",null,"In 24 patients with Eclampsia or pre-eclampsia investigators will use an artefact-free 20-min mean BIS value, as well as biomarkers sFIT (soluble FMS-like Tyrosine Kinase): PIGF (Placental Growth Factor) ratio and adrenomedullin mortality risk stratifier to classify the degree of pre-eclampsia correlated the PIERS Pre-eclampsia risk assessment PIERS percentage (http:\u002F\u002Fpiers.cfri.ca\u002FPIERSCalculatorH.aspx) will be calculated from patients' clinical and laboratory findings documented in their charts.",{"label":13,"type":10,"description":14,"interventionNames":10},"Control","In 24 control patients without Eclampsia or pre-eclampsia investigators will use an artefact-free 20-min mean BIS value, as well as biomarkers sFIT (soluble FMS-like Tyrosine Kinase): PIGF (Placental Growth Factor) ratio and adrenomedullin mortality risk stratifier to classify the degree of pre-eclampsia correlated the PIERS Pre-eclampsia risk assessment PIERS percentage (http:\u002F\u002Fpiers.cfri.ca\u002FPIERSCalculatorH.aspx) will be calculated from patients' clinical and laboratory findings documented in their charts",[16],{"name":17,"affiliation":18,"role":19},"Ashraf Dahaba, MD","Guest Professor","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","00436509006761","ashraf.dahaba@medunigraz.at",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Medical Ethics Committee, University Malaya Medical Centre","RECRUITING","Kuala Lumpur","Malaysia","MY",{"type":33,"coordinates":34},"Point",[35,36],101.68653,3.1412,{"lat":36,"lon":35},[39],{"name":40,"role":22,"phone":10,"phoneExt":10,"email":24},"Ashraf Dahaba",{"type":19,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ashraf A. Dahaba","Principle Investigator",[45],{"name":46,"class":6},"University of Malaya","100253506","piers-and-bis-sfitpigf-adrenomedullin-100253506",false,"NCT02578810","PIERS and BIS, sFIT:PIGF, Adrenomedullin","Sensitivity and Specificity of Bispectral Index (BIS) EEG Parameter, sFIT (Soluble FMS Tyrosine Kinase): PIGF (Placental Growth Factor) Ratio, Adrenomedullin for Grading Preeclampsia Integrated Estimate Risk Score (PIERS)","BIS2","Inclusion Criteria\n\n1. Pregnancy at any stage (3 trimesters)\n2. Eclampsia (Frank eclampsia) will be the crux of the study\n3. Pre-eclampsia that is suspected will end up with Frank Eclampsia\n\nExclusion criteria:\n\n1. Any neurological conditions that can alter the electroencephalography like epilepsy\n2. Any medical conditions that can alter the electroencephalography like hypoglycemia","FEMALE","18 Years","50 Years",{"count":59,"type":60},48,"ESTIMATED","OBSERVATIONAL","Pre-eclampsia, more than being proteinuric gestational hypertension alone, is a state of exaggerated systemic inflammation and remains a leading direct cause of maternal morbidity and mortality worldwide.1 Standardization of antenatal and postnatal assessment and surveillance of pre-eclampsia with protocols that recognize the systemic inflammatory model of preeclampsia have been associated with reduced maternal morbidity.",[9],"2026-04-22",{"date":66,"type":67},"2026-04-23","ACTUAL",{"date":69,"type":10},"2016-10",{"date":71,"type":60},"2030-12",{"name":5,"class":6},1]