[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575433":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":62,"collaborators":20,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":20,"eligibilityCriteria":70,"healthyVolunteers":67,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":20,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":48,"whyStopped":20,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Oregon Health and Science University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"B vitamin regimen","EXPERIMENTAL","Daily doses of 1mg folic acid, 25mg vitamin B6, and 1,000 ug vitamin B12.",[13,14,15],"Dietary Supplement: Folic Acid 1 MG","Dietary Supplement: Vitamin B6 25 MG","Dietary Supplement: Vitamin B12",{"label":17,"type":18,"description":19,"interventionNames":20},"No vitamins","NO_INTERVENTION","No vitamin intervention.",null,[22,27,31],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":20},"DIETARY_SUPPLEMENT","Folic Acid 1 MG","Folic Acid 1mg per day",[9],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":20},"Vitamin B6 25 MG","Vitamin B6, 25mg per day",[9],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":20},"Vitamin B12","Vitamin B12, 1,000 ug per day",[9],[36],{"name":37,"affiliation":38,"role":39},"Joseph Quinn, MD","Oregon Health & Science University (OHSU)","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":20,"email":45},"Madeline Armendariz Sullivan","CONTACT","503-501-8478","PDResearch@ohsu.edu",[47],{"facility":38,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Portland","Oregon","97239","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-122.67621,45.52345,{"lat":58,"lon":57},[61],{"name":42,"role":43,"phone":44,"phoneExt":20,"email":45},{"type":39,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Joseph Quinn","OHSU Parkinson Center Director","100575433","pilot-study-of-open-label-homocysteine-management-therapy-in-levodopa-treated-parkinsons-disease-100575433",false,"NCT06772220","Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease","Inclusion Criteria:\n\n1. Diagnosis of probable Parkinson's Disease according to Movement Disorders Society criteria.\n2. Currently treated with levodopa at a minimum dose of 300 mg\u002Fday\n3. Montreal Cognitive Assessment (MOCA) ≥15\n4. Demonstrated capacity to provide informed consent.\n5. 40-90 years of age\n6. Estimated glomerular filtration rate ≥60\n7. Absence of uncontrolled hypertension in medical history\n8. Absence of insulin use\n\nExclusion Criteria:\n\n\\-","ALL","40 Years","90 Years",{"count":75,"type":76},150,"ESTIMATED","INTERVENTIONAL",[79],"NA","This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.",[82],"Parkinson&Amp;#39;s Disease",[84,85,86],"Parkinson's disease","Parkinson disease","homocysteine","2025-01-08",{"date":89,"type":90},"2025-01-13","ACTUAL",{"date":92,"type":90},"2024-03-05",{"date":94,"type":76},"2025-12-31",{"name":5,"class":6},1]