[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604640":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":27,"locations":37,"responsibleParty":64,"collaborators":27,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":27,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":92,"whyStopped":27,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Parc de Salut Mar","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tSCS + Rehabilitation","EXPERIMENTAL","Participants will receive active transcutaneous spinal cord stimulation (tSCS) using the SCONE™ device, combined with conventional upper limb rehabilitation therapy.",[13,14],"Device: Active stimulation tSCS","Behavioral: Occupational\u002FUpper Limb Rehabilitation Therapy",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham tSCS + Rehabilitation","SHAM_COMPARATOR","Participants will receive sham stimulation using the SCONE™ device without active current, combined with conventional upper limb rehabilitation therapy. The setup will be identical to the active intervention to maintain blinding.",[20,14],"Device: Sham: stimulations using a non-active electric stimulation",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Active stimulation tSCS","Active transcutaneous spinal cord stimulation (tSCS) delivered with the SCONE™ device. Electrical currents are applied non-invasively through surface electrodes placed on the skin over the spine. Sessions are combined with standardized upper limb rehabilitation therapy. Participants receive stimulation twice per week for 12 weeks.",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Sham: stimulations using a non-active electric stimulation","Sham stimulation delivered with the SCONE™ device, using identical setup and procedures as the active intervention but without effective current. This procedure is designed to mimic the sensation and experience of active stimulation while delivering no therapeutic neuromodulation. Participants also perform standardized upper limb rehabilitation therapy twice per week for 12 weeks.Transcutaneous Spinal Cord Stimulation (tSCS) - Sham (SCONE™)",[16],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"BEHAVIORAL","Occupational\u002FUpper Limb Rehabilitation Therapy","Standardized occupational therapy program focused on upper limb function. Sessions are delivered in combination with either active or sham transcutaneous spinal cord stimulation.",[9,16],[38],{"facility":39,"status":27,"city":40,"state":27,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Hospital del Mar","Barcelona","08003","Spain","ES",{"type":45,"coordinates":46},"Point",[47,48],2.15899,41.38879,{"lat":48,"lon":47},[51,56,60,62],{"name":52,"role":53,"phone":54,"phoneExt":27,"email":55},"Pablo Villoslada, MD, PhD","CONTACT","+34933160455","pvilloslada@researchmar.net",{"name":57,"role":53,"phone":27,"phoneExt":58,"email":59},"Silvia Susin, MD","1438","ssusin@researchmar.net",{"name":52,"role":61,"phone":27,"phoneExt":27,"email":27},"PRINCIPAL_INVESTIGATOR",{"name":57,"role":63,"phone":27,"phoneExt":27,"email":27},"SUB_INVESTIGATOR",{"type":61,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PAblo Villoslada","Principal Investigator, Neurology Department, Hospital del Mar Research Institute","100604640","pilot-study-of-tscs-for-improving-upper-limb-function-in-people-with-multiple-sclerosis-100604640",false,"NCT07152145","Pilot Study of tSCS for Improving Upper Limb Function in People With Multiple Sclerosis","Transcutaneous Electrical Spinal Stimulation (tSCS) for Improving Upper Limb Function in People With MS","tSCS-MS","Inclusion Criteria:\n\n* Age between 18 and 70 years.\n* Diagnosis of Multiple Sclerosis (according to revised McDonald criteria).\n* Upper limb dysfunction (9-Hole Peg Test score ≥ 20% slower than normative values).\n* Stable disease-modifying treatment for ≥ 6 months before enrollment.\n* Expanded Disability Status Scale (EDSS) score between 3.0 and 6.5.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Relapse or corticosteroid treatment within the last 3 months.\n* Severe spasticity of the upper limb (Modified Ashworth Scale \\> 3).\n* Implanted electrical devices (pacemaker, spinal cord stimulator).\n* Epilepsy or uncontrolled seizures.\n* Severe psychiatric disorders or cognitive impairment interfering with study procedures.\n* Pregnant or breastfeeding women.\n* Participation in another interventional clinical trial within the last 3 months.","ALL","18 Years","70 Years",{"count":79,"type":80},60,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this clinical trial is to evaluate whether non-invasive spinal cord neuromodulation with the SCONE™ device can improve upper limb function in people with multiple sclerosis. The study will investigate if combining SCONE™ therapy with rehabilitation exercises leads to improvements in arm and hand movement, and whether the therapy is safe and well tolerated in this patient population. Participants will receive non-invasive spinal cord stimulation with the SCONE™ device and perform rehabilitation exercises specifically focused on the upper limb.",[86],"Multiple Sclerosis",[88,89,90,91],"Spinal Cord Neuromodulation","Non-invasive neuromodulation","Upper limb function","Neurorehabilitation","NOT_YET_RECRUITING","2025-08-28",{"date":95,"type":96},"2025-09-03","ACTUAL",{"date":98,"type":80},"2025-10",{"date":100,"type":80},"2026-12",{"name":5,"class":6},1]