[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579142":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":33,"locations":40,"responsibleParty":59,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Nantes University Hospital","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1. Controls (n=45)",null,"* Women with no laparoscopically confirmed signs of deep endometriosis.\n* No clinico-biological criteria in favour of a diagnosis of endometriotic disease, nor any radiological signs (ultrasound or MRI) suggestive of endometriosis.\n\nA blood test (2 x 5 ml dry tubes) and a 20 ml urine sample will be taken to analyze steroid profiles, as well as a vaginal sample to characterize the microbiota.",[13,14,15],"Other: Blood test","Other: urine sample","Other: vaginal sample",{"label":17,"type":10,"description":18,"interventionNames":19},"Group 2. Deep endometriosis (n = 90)","* 45 patients with endometriome\n* 45 patients without endometriome Deep endometriosis confirmed by surgery or MRI Newly diagnosed women (less than 12 months).\n* Severe, deep-seated endometriotic pathology with surgical indication (clinical examination, imaging tests, pre-operative findings).\n\nA blood test (2 x 5 ml dry tubes) and a 20 ml urine sample will be taken to analyze steroid profiles, as well as a vaginal sample to characterize the microbiota.",[13,14,15],[21,25,29],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Blood test","A blood test (2 x 5 ml dry tubes) will be taken to analyze steroid profiles",[9,17],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"urine sample","a 20 ml urine sample will be taken to analyze steroid profiles",[9,17],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"vaginal sample","to characterize the microbiota.",[9,17],[34],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"Stéphane PLOTEAU, PU-PH","CONTACT","02.40.08.76.84","+33","Stéphane.ploteau@chu-nantes.fr",[41],{"facility":42,"status":43,"city":44,"state":10,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"CHU de Nantes","RECRUITING","Nantes","44093","France","FR",{"type":49,"coordinates":50},"Point",[51,52],-1.55336,47.21725,{"lat":52,"lon":51},[55],{"name":56,"role":36,"phone":57,"phoneExt":10,"email":58},"Stéphane PLOTEAU","0240087684","stephane.ploteau@chu-nantes.fr",{"type":60,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100579142","pilot-study-to-characterize-the-endometriosis-steroidome-and-its-link-to-endocrine-disruptors-and-vaginal-dysbiosis-100579142",false,"NCT06820450","Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis","STERONLINE: Steroidome and Exposome of Endometriosis Single-center Case-control Study","STERONLINE","Inclusion Criteria:\n\n* Women aged 18 to 45\n* Free, informed and written consent from the patient to participate in the study\n* Good understanding of the French language\n* Patient affiliated to or benefiting from a social security or similar scheme\n\nSpecific inclusion criteria for each group:\n\nGroup 1. Controls.\n\n* Women with no laparoscopically confirmed signs suggestive of deep endometriosis.\n* No clinico-biological criteria in favour of a diagnosis of endometriotic disease, nor any radiological signs (ultrasound or MRI) suggestive of endometriosis.\n\nGroup 2. Cases of deep endometriosis.\n\n* Newly diagnosed women (less than 12 months).\n* Severe, deep endometriotic pathology with surgical indication (clinical examination, imaging tests, pre-operative findings).\n\nExclusion Criteria:\n\n* Intercurrent diagnosis of pregnancy.\n* Presence of other hormone-dependent pathologies (e.g. breast cancer, PCOS).\n* Acute infection.","FEMALE","18 Years","45 Years",{"count":73,"type":74},135,"ESTIMATED","OBSERVATIONAL","Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age. The etiology and pathophysiology of endometriosis is not completely understood to support effective treatment and prevention strategies. Despite the steroid dependency, little is known concerning the underlying metabolism of estrogen and other tightly related steroids. Moreover, shortening the long diagnostic delays is a major priority in endometriosis research.",[78],"Endometriosis",[80,81,82],"Steroidome","exposome","LC-HRMS","2026-06-23",{"date":85,"type":86},"2026-06-24","ACTUAL",{"date":88,"type":86},"2025-07-01",{"date":90,"type":74},"2027-07-01",{"name":5,"class":6},1]