[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477747":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":24,"centralContacts":28,"locations":38,"responsibleParty":57,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":10,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":10,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",[8,12,15,18,20,22],{"label":9,"type":10,"description":11,"interventionNames":10},"Short track controls",null,"Controls are women (18 years or older) with an uncomplicated pregnancy (i.e no foetal or maternal placental complications, such as pregnancy induced hypertension, preeclampsia or HELLP-syndrome, or small for gestational birth infancies).\n\nFollow up roughly 18 months postpartum.",{"label":13,"type":10,"description":14,"interventionNames":10},"Short track early PE with IUGR","These cases consist of women (18 years or older) with preeclampsia (PE) and\u002For HELLP syndrome in the current pregnancy (PE is defined as hypertension (systolic blood pressure ≥ 140 mmHg and\u002For diastolic BP ≥ 90 mmHg) developed after 20 weeks of pregnancy with de novo proteinuria (≥ 300 mg\u002F 24 hours)) Cases will be subdivided into early and late PE, with or without IUGR (Early PE is defined as the occurence of PE \\\u003C 34 weeks of gestation, whereas late PE is defined as the occurence of PE ≥ 34 weeks of gestation. IUGR is defined as birthweight below the 10th percentile).\n\nFollow up roughly 18 months postpartum.",{"label":16,"type":10,"description":17,"interventionNames":10},"Short track early PE without IUGR","Cases consist of women (18 years or older) with preeclampsia (PE) and\u002For HELLP syndrome in the current pregnancy (PE is defined as hypertension (systolic blood pressure ≥ 140 mmHg and\u002For diastolic BP ≥ 90 mmHg) developed after 20 weeks of pregnancy with de novo proteinuria (≥ 300 mg\u002F 24 hours)) Cases will be subdivided into early and late PE, with or without IUGR (Early PE is defined as the occurence of PE \\\u003C 34 weeks of gestation, whereas late PE is defined as the occurence of PE ≥ 34 weeks of gestation. IUGR is defined as birthweight below the 10th percentile).\n\nFollow up roughly 18 months postpartum.",{"label":19,"type":10,"description":17,"interventionNames":10},"Short track late PE with IUGR",{"label":21,"type":10,"description":17,"interventionNames":10},"Short track late PE without IUGR",{"label":23,"type":10,"description":17,"interventionNames":10},"Long term follow up track cases",[25],{"name":26,"affiliation":5,"role":27},"Marc Spaanderman, MD, PhD","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Gwyneth Jansen, MBBS","CONTACT","043-38774145","gwyneth.jansen@mumc.nl",{"name":26,"role":31,"phone":35,"phoneExt":36,"email":37},"043-38774774","0031","marc.spaanderman@mumc.nl",[39],{"facility":40,"status":41,"city":42,"state":10,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Maastricht University Medical Center (MUMC+)","RECRUITING","Maastricht","6202 AZ","Netherlands","NL",{"type":47,"coordinates":48},"Point",[49,50],5.68889,50.84833,{"lat":50,"lon":49},[53,55],{"name":30,"role":31,"phone":54,"phoneExt":36,"email":33},"043 - 38774145",{"name":26,"role":31,"phone":56,"phoneExt":36,"email":37},"043 - 38774774",{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100477747","placental-acute-atherosis-reflecting-subclinical-atherosclerosis-100477747",false,"NCT05500989","PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis","PEARLS","Inclusion Criteria:\n\n* Women aged ≥ 18 years\n* Controls: Women with an uncomplicated pregnancy at the moment of inclusion (i.e no foetal or maternal placental complications, such as pregnancy induced hypertension, preeclampsia or HELLP-syndrome, or small for gestational birth infancies)\n* Cases: Women diagnosed with a preeclamptic pregnancy at the moment of inclusion\n\nExclusion Criteria:\n\n• Women who do not want to be informed about the results of the tests, or women who do not want their general practitioner and specialist(s) to be informed about the test results\n\n* Allergy or intolerance to glyceryl trinitrate, betablockers or iodinated contrast media.\n* Controls: Pre-existing chronic hypertension treated with antihypertensive medication or autoimmune disorder.",true,"FEMALE","18 Years",{"count":70,"type":71},226,"ESTIMATED","OBSERVATIONAL","Pregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life. Moreover, it is known that often the pregnancy induced CV adaptation does not resolve completely after a short postpartum (PP) period and it is not clear whether these induced changes will resolve over a longer period of time (i.e. in the upcoming months\u002Fyears after delivery).\n\nUnderstanding the cardiac adaptation during pregnancy and the reversal process in the postpartum period, as well as the factors that influence this these processes, may provide us not only insight in this mechanism, but may help us in identifying factors that may be target points for modification.",[75,76,77,78],"Pre-Eclampsia","HELLP Syndrome","Intrauterine Growth Restriction","Pregnancy","2024-12-03",{"date":81,"type":82},"2024-12-05","ACTUAL",{"date":84,"type":82},"2016-11",{"date":86,"type":71},"2028-12",{"name":5,"class":6},1]