[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645316":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":58,"collaborators":60,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":25,"enrollmentInfo":77,"targetDuration":25,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":96,"whyStopped":25,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University Hospital, Clermont-Ferrand","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control diet group","ACTIVE_COMPARATOR","Participants follow a standard diet for older adults with approximately 70% of protein from animal sources and 30% from plant sources. Nutritional guidance and follow-up are provided throughout the 3-month study period. Participants maintain their usual eating habits within these proportions, and dietary compliance is monitored through food diaries and regular consultations with the study team.",[13],"Other: Control diet",{"label":15,"type":16,"description":17,"interventionNames":18},"Plant-enriched diet group","EXPERIMENTAL","Participants follow a diet enriched in plant-based foods, with approximately 70% of protein from plant sources and 30% from animal sources, while maintaining adequate total protein intake. Participants receive tailored dietary guidance and support from the study team over 3 months, including meal planning and regular follow-up. Dietary compliance is assessed using food diaries, recalls, and periodic monitoring by the study team.",[19],"Other: Plant-enriched dietary intervention",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Plant-enriched dietary intervention","Participants follow a diet enriched in plant-based foods with approximately 70% of protein from plant sources and 30% from animal sources for 3 months, with tailored dietary guidance, meal planning support, and compliance monitored through food diaries and periodic follow-up.",[15],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Control diet","Participants follow a standard diet with approximately 70% of protein from animal sources and 30% from plant sources for 3 months, with general nutritional guidance and compliance monitored through food diaries and periodic consultations.",[9],[31],{"name":32,"affiliation":5,"role":33},"Yves BOIRIE","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Lise LACLAUTRE","CONTACT","+33475754963","promo_interne_drci@chu-clermontferrand.fr",[41],{"facility":42,"status":25,"city":43,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"CHU de Clermont-Ferrand","Clermont-Ferrand","France","FR",{"type":47,"coordinates":48},"Point",[49,50],3.08682,45.77969,{"lat":50,"lon":49},[53,56],{"name":54,"role":37,"phone":55,"phoneExt":25,"email":39},"Lise Laclautre","+33473754963",{"name":57,"role":33,"phone":25,"phoneExt":25,"email":25},"Yves Boirie",{"type":59,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[61,64,66],{"name":62,"class":63},"Centre de Recherche en Nutrition Humaine d'Auvergne","OTHER_GOV",{"name":65,"class":6},"Université d'Auvergne",{"name":67,"class":6},"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","100645316","plant-based-diet-in-older-people-what-consequences-for-muscle-health-100645316",false,"NCT07681986","Plant-based Diet in Older People: What Consequences for Muscle Health?","MYOVEG","Inclusion Criteria:\n\n* Men and women aged 65 years and older\n* Body Mass Index (BMI) between 18.5 and 30 kg\u002Fm² (exclusive)\n* Physical activity \\\u003C 3000 MET-min\u002Fweek, assessed using the ONAPS-PAQ questionnaire\n* Laboratory tests compatible with participation in the study\n* Adequate venous status, as assessed by study nurses, allowing catheter placement\n* Willingness to participate in study procedures, including indirect calorimetry, functional tests, and assigned dietary intervention (plant-enriched or standard diet)\n* Affiliation with the French Social Security system\n\nExclusion Criteria:\n\n* Men and women aged 65 years and older\n* Body Mass Index (BMI) between 18.5 and 30 kg\u002Fm² (exclusive)\n* Physical activity \\\u003C 3000 MET-min\u002Fweek, assessed using the ONAPS-PAQ questionnaire\n* Laboratory tests compatible with participation in the study\n* Adequate venous status, as assessed by study nurses, allowing catheter placement\n* Willingness to participate in study procedures, including indirect calorimetry, functional tests, and assigned dietary intervention (plant-enriched or standard diet)\n* Affiliation with the French Social Security system\n* Exclusion period from a previous study or total compensation exceeding €6,000 in the 12 months prior to study initiation (verified through the National Research Volunteer Database)\n* Patients under legal guardianship, curatorship, deprived of liberty, or under judicial protection\n* Claustrophobia","ALL","65 Years",{"count":78,"type":79},60,"ESTIMATED","INTERVENTIONAL",[82],"NA","This randomized, controlled, two-arm clinical study aims to determine how increasing the proportion of plant-based foods in the diet affects skeletal muscle strength, mass and function, protein metabolism, microbiota and key metabolic markers in healthy older men and women. We hypothesize that diets enriched with animal-based foods will maintain maximal quadriceps strength-the primary outcome of the study-more effectively after the 3-month nutritional intervention than plant-based diets. Proteomic analyses will be performed to identify molecular mechanisms and potential muscle biomarkers reflecting metabolic adaptations of skeletal muscle to plant-enriched diets. In addition, metabolic health markers and micronutrient status will be evaluated to better understand the overall health effects of dietary plant-based transition in older adults.",[85],"Aging",[85,87,88,89,90,91,92,93,94,95],"Older Adults","Plant-Based Diet","Muscle Strength","Skeletal Muscle","Protein Metabolism","Physical Performance","Proteomics","Body Composition","Gut Microbiota","NOT_YET_RECRUITING","2026-06-26",{"date":99,"type":100},"2026-07-02","ACTUAL",{"date":102,"type":79},"2026-07-20",{"date":104,"type":79},"2030-08",{"name":5,"class":6},1]