[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623688":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":44,"responsibleParty":78,"collaborators":80,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":87,"sex":93,"minAge":94,"maxAge":25,"enrollmentInfo":95,"targetDuration":25,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Radboud University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Plant-based ONS","EXPERIMENTAL","In this arm, patients who are advised, as part of usual care, to use at least two bottles of oral nutritional supplements (ONS) per day are randomized to the plant-based group. Participants receive plant-based ONS, with the daily amount prescribed by the dietitian according to usual care.",[13],"Dietary Supplement: Fresubin Plant-based drink vanilla©",{"label":15,"type":10,"description":16,"interventionNames":17},"Animal-based ONS","In this arm, patients who are advised, as part of usual care, to use at least two bottles of oral nutritional supplements (ONS) per day are randomized to the animal-based group. Participants receive animal-based ONS, with the daily amount prescribed by the dietitian according to usual care.",[18],"Dietary Supplement: Fresubin Yodrink raspberry©",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Fresubin Plant-based drink vanilla©","Patients will receive plant-based oral nutritional supplements (ONS). The amount of bottles ONS a day, will be based on their nutritional intake versus requirements by a dietitian. This is usual care, only the sort of ONS differs from normal care.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Fresubin Yodrink raspberry©","Patients will receive animal-based oral nutritional supplements (ONS). The amount of bottles ONS a day, will be based on their nutritional intake versus requirements by a dietitian. This is usual care, only the sort of ONS differs from normal care.",[15],[31],{"name":32,"affiliation":5,"role":33},"Maud Reintjes, MSc","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Manon van den Berg, PhD","CONTACT","+31 6 12 44 00 88","manon.vandenberg@radboudumc.nl",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Sandra Beijer, PhD","+31 6 11 15 61 04","sandra.beijer@mumc.nl",[45,62],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Radboud university medical center","RECRUITING","Nijmegen","Gelderland","6525 GA","Netherlands","NL",{"type":54,"coordinates":55},"Point",[56,57],5.85278,51.8425,{"lat":57,"lon":56},[60,61],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":63,"status":47,"city":64,"state":65,"zip":66,"country":51,"countryCode":52,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Maastricht University Medical Center","Maastricht","Limburg","6229 HX",{"type":54,"coordinates":68},[69,70],5.68889,50.84833,{"lat":70,"lon":69},[73,76],{"name":32,"role":37,"phone":74,"phoneExt":25,"email":75},"+31650155752","maud.reintjes@mumc.nl",{"name":41,"role":37,"phone":77,"phoneExt":25,"email":43},"+31611156104",{"type":79,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[81,84],{"name":82,"class":83},"Fresenius Kabi","INDUSTRY",{"name":63,"class":6},"100623688","plant-based-versus-animal-based-oral-nutritional-supplements-100623688",false,"NCT07399886","Plant-based Versus Animal-based Oral Nutritional Supplements","PlAnt Vs Animal Based Oral Nutritional Supplements: Patients' Opinions and Nutritional Outcomes: A Multicenter Pilot Feasibility Study","PAVOS","Inclusion Criteria:\n\n* Clinical patients with cancer and lung diseases, cardiology patients, patients with cardiothoracic surgery, and orthopaedic patients age ≥18 years, and treated at Radboudumc or Maastricht UMC+.\n* Patients who have been advised at least 2 bottles of ONS daily based on a high risk of malnutrition (MUST≥2, PG-SGA-SF≥ 9) and\u002For by the dietitians expertise.\n* Written informed consent (IC)\n\nExclusion Criteria:\n\n* Patients who are or become dependent on tube or parenteral nutrition\n* Patients where life-extending therapy is no longer possible\n* Unable to follow up study instructions\n* Lactose intolerance\n* Soy allergy\u002Fintolerance\n* Vegan diet\n* Patients who have used ONS in the past six months","ALL","18 Years",{"count":96,"type":97},60,"ESTIMATED","INTERVENTIONAL",[100],"NA","Background information:\n\nMany people who are admitted to the hospital are at risk of malnutrition. In some patient groups, this can be as high as 40%. When someone is not eating enough, the dietitian often recommends oral nutritional supplements (ONS). These are energy- and protein-rich drinks that help patients get enough nutrition. They can reduce complications, lower the chance of being readmitted to the hospital, and help improve body weight and physical functioning.\n\nIn the Netherlands, the Ministry of Health and the Dutch Federation of University Medical Centers have signed the Green Deal \"Working together on sustainable care.\" One of the goals is to make healthcare greener and climate-neutral by 2026. This also applies to medical and non-medical nutrition, including ONS.\n\nBecause of this, there is increasing attention on developing ONS that contain more plant-based proteins, which may be more sustainable.\n\nWhat do will the investigators find out?\n\nIt is unknown how plant-based ONS work when patients use them for a longer period of time. For example:\n\n* Do they help patients get enough energy and protein?\n* What are the effects on physical and clinical outcomes? Before a large study with many patients is started, it is important to first test whether this type of research is feasible.\n\nFeasibility in terms of\n\n* Recruitment rate\n* Drop-out rate\n* Adherence to the ONS advice\n* Study measurements (succesfull vs unsuccesfull measurements)\n\nTo answer these questions, a smaller pilot study will be conducted in which plant-based ONS will be compared to animal-based ONS.\n\nWhat does this study look like?\n\nInclusion criteria:\n\nPatients from the departments of medical oncology, lung diseases, cardiology, cardiothoracic surgery, and orthopedics at Maastricht UMC+ and Radboudumc. These are patients who are currently not eating enough.\n\nThese patients receive advice from the dietitian to take at least two bottles of ONS per day. If they want to participate in the study, they will be randomly assigned to one of two products:\n\n* Animal-based (milk protein): Fresubin YoDrink Raspberry©\n* Plant-based (soy protein): Fresubin Plant-Based Drink Vanilla©\n\nMeasurements will be performed at the start of the study and again after three months. In the meantime, the researcher will contact the patient twice by phone to ask how things are going.",[103],"Risk of Malnutrition",[105,106,107,108,109,110,111,112,113],"plant-based ONS","animal-based ONS","Risk of malnutrition","pilot feasibility","hospitalized patients","oral nutritional drinks","plant protein","sustainability","medical nutrition","2026-02-11",{"date":116,"type":117},"2026-02-17","ACTUAL",{"date":119,"type":117},"2025-11-10",{"date":121,"type":97},"2026-11-01",{"name":5,"class":6},2]