[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595306":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":45,"locations":46,"responsibleParty":65,"collaborators":45,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":45,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":45,"enrollmentInfo":76,"targetDuration":45,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":90,"overallStatus":109,"whyStopped":45,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Tel-Aviv Sourasky Medical Center","OTHER_GOV",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"ProLegumes Diet","EXPERIMENTAL","Participants in this arm will follow a hypocaloric, high-protein diet primarily based on legumes as the main protein source. The diet aims to improve sarcopenic obesity outcomes over a 3-month intervention period, combined with home-based resistance training.",[13],"Behavioral: Legume-Based High-Protein Diet + Resistance Training",{"label":15,"type":16,"description":17,"interventionNames":18},"ProMeat Diet","ACTIVE_COMPARATOR","Participants in this arm will follow a hypocaloric, high-protein diet primarily based on meat as the main protein source. This diet also aims to improve sarcopenic obesity outcomes over 3 months with the same exercise regimen.",[19],"Behavioral: Meat-Based High-Protein Diet + Resistance Training",{"label":21,"type":16,"description":22,"interventionNames":23},"ProMix Diet","Participants in this arm will follow a hypocaloric, high-protein diet that includes a combination of both legumes and meat as protein sources. The intervention period and exercise program are identical to the other arms.",[24],"Behavioral: Mixed Legume and Meat High-Protein Diet + Resistance Training",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"BEHAVIORAL","Legume-Based High-Protein Diet + Resistance Training","Participants receive a hypocaloric, high-protein diet primarily based on legumes (e.g., lentils, beans, peas) designed to meet protein goals (\\~2g\u002Fkg body weight). Diet is combined with a structured home-based resistance training program performed 3 times per week for 12 weeks. The exercise includes progressive resistance exercises focusing on major muscle groups using body weight and resistance bands.",[9],[32],"ProLegumes",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Meat-Based High-Protein Diet + Resistance Training","Participants follow a hypocaloric, high-protein diet emphasizing animal-based protein sources, mainly lean meats, to achieve \\~2g\u002Fkg body weight protein intake. This dietary intervention is combined with a 12-week, home-based resistance training protocol, performed thrice weekly, targeting major muscle groups with progressive overload using body weight and resistance bands.",[15],[38],"ProMeat",{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Mixed Legume and Meat High-Protein Diet + Resistance Training","Participants adhere to a hypocaloric, high-protein diet combining both legumes and lean meats as protein sources to reach \\~2g\u002Fkg body weight. The dietary plan is paired with a 12-week home-based resistance training program, performed 3 times per week, emphasizing progressive resistance exercises for all major muscle groups using body weight and resistance bands.",[21],[44],"ProMix",null,[47],{"facility":48,"status":45,"city":49,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Tel Aviv Sourasky Medical Center","Tel Aviv","6423906","Israel","IL",{"type":54,"coordinates":55},"Point",[56,57],34.78057,32.08088,{"lat":57,"lon":56},[60],{"name":61,"role":62,"phone":63,"phoneExt":45,"email":64},"Assaf Buch, Professor","CONTACT","+972 54-993-1033","buchasaf@gmail.com",{"type":66,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR","100595306","plant-vs-animal-based-protein-sources-as-an-anabolic-and-metabolic-protective-options-for-so-in-older-adults-100595306",false,"NCT07030738","Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults","Plant (Legumes) vs Animal-based (Meat) Protein Sources as an Anabolic and Metabolic-protective Options for Sarcopenic Obesity in Older Adults- A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 55 years or older.\n* Diagnosed with obesity.\n* At risk for sarcopenia, based on at least one of the following: Low score on the validated SARC-F-calf questionnaire (as suggested in prior studies). More than one comorbidity associated with sarcopenic obesity (e.g., diabetes, osteoporosis, cardiovascular disease, etc.). Polypharmacy: taking 8 or more prescribed medications. Evidence of strength or functional impairment, assessed using validated measurements at the baseline visit.\n\nExclusion Criteria:\n\n* Recent use of steroid agents within the past 6 months (replacement therapy is allowed).\n* Uncorrected hypothyroidism: TSH \\> 6 mIU\u002FL.\n* Diagnosis of malignancy within the past 5 years, except for non-melanoma skin cancer.\n* Chronic kidney disease (CKD) at stage \\>1 (due to protein restriction needs).\n* Recent (≤6 months) or unstable cardiovascular condition, or NYHA Class III or higher congestive heart failure.\n* Currently performing resistance training.\n* Currently undergoing nutritional therapy, have recently changed diet (\\\u003C1 month), or are enrolled in active weight-loss programs or therapies (including lifestyle and\u002For pharmacotherapy). Note: Patients stable on GLP-1 agonists or other pharmacotherapy are eligible.\n* Vegetarians\u002Fvegans, or individuals with aversion or allergy to all legumes or all red meat products.\n* Habitual consumption of more than 3 servings\u002Fweek of either legumes or red meat.\n* Other medical, psychiatric conditions, or lab abnormalities that may pose a risk to participation.","ALL","55 Years",{"count":77,"type":78},180,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study is testing how different types of protein - from red meat, legumes (like lentils and beans), or a mix of both - affect muscle strength, body composition, and metabolic health in older adults with obesity who are also at risk for sarcopenia (loss of muscle mass and function). Participants will follow a personalized weight loss diet with one high-protein meal each day that includes either red meat, legumes, or both, along with a home-based strength training program. The study will last three months and will include health assessments such as blood tests, muscle and fat measurements, and physical function tests. The goal is to find out which type of protein source is most helpful for improving strength, reducing body fat, and supporting healthy aging.",[84,85,86,87,88,89],"Sarcopenic Obesity","Obesity and Obesity-related Medical Conditions","Obesity (Body Mass Index >30 kg\u002Fm2)","Sarcopenia","Muscle Loss","Aging",[91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108],"Plant-based diet","Red meat","Legumes","Protein intake","Anabolic diet","Resistance training","Muscle mass","Body composition","Older adults","Functional status","Sarcopenic obesity","Hypocaloric diet","Leucine","Physical function","Metabolic health","Aging population","Nutrition intervention","Randomized controlled trial","NOT_YET_RECRUITING","2025-06-12",{"date":112,"type":113},"2025-06-22","ACTUAL",{"date":115,"type":78},"2025-09",{"date":117,"type":78},"2026-06",{"name":5,"class":6},1]