[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588626":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":36,"locations":41,"responsibleParty":59,"collaborators":18,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":18,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":18,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":44,"whyStopped":18,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Nebraska","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Aged Participants Treated with Platelet-rich Fibrinogen","ACTIVE_COMPARATOR","Participants aged 50 to 80 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.",[13],"Procedure: Platelet-rich fibrin (PRF)",{"label":15,"type":16,"description":17,"interventionNames":18},"Aged Control","NO_INTERVENTION","Participants aged 50 to 80 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.",null,{"label":20,"type":10,"description":21,"interventionNames":22},"Young Participants Treated with Platelet-rich Fibrinogen","Participants aged 14 to 18 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.",[13],{"label":24,"type":16,"description":25,"interventionNames":18},"Young Control","Participants aged 14 to 18 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.",[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":18},"PROCEDURE","Platelet-rich fibrin (PRF)","Platelet-rich fibrin added to extraction socket",[9,20],[33],{"name":34,"affiliation":5,"role":35},"Amy C Killeen, DDS, MS","PRINCIPAL_INVESTIGATOR",[37],{"name":34,"role":38,"phone":39,"phoneExt":18,"email":40},"CONTACT","402-472-7848","akilleen@unmc.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"University of Nebraska Medical Center College of Dentistry","RECRUITING","Lincoln","Nebraska","68358","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-96.66696,40.8,{"lat":54,"lon":53},[57],{"name":34,"role":38,"phone":58,"phoneExt":18,"email":40},"402-472-7948",{"type":60,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100588626","platelet-rich-fibrinogen-in-extraction-socket-healing-of-the-aged-100588626",false,"NCT06943846","Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged","Wound Healing Outcomes in Aged Extraction Patient With Platelet Rich Fibrinogen","Inclusion Criteria:\n\n* Patient at University of Nebraska Medical Center (UNMC) College of Dentistry\n* Requires extraction of posterior tooth\n* Able and willing to provide consent\u002Fassent\n\nExclusion Criteria:\n\n* Systemic conditions that delay wound healing\n* Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy","ALL","14 Years","80 Years",{"count":72,"type":73},12,"ESTIMATED","INTERVENTIONAL",[76],"NA","The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.",[79],"Edentulism",[81,82,83,84],"extraction","platelet-rich","fibrin","healing","2026-01-23",{"date":87,"type":88},"2026-01-27","ACTUAL",{"date":90,"type":88},"2025-05-01",{"date":92,"type":73},"2027-05",{"name":5,"class":6},1]