[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100473127":3},{"organization":4,"armGroups":7,"interventions":69,"overallOfficials":154,"centralContacts":188,"locations":199,"responsibleParty":1392,"collaborators":74,"id":1394,"slug":1395,"hasResults":1396,"nctId":1397,"briefTitle":1398,"officialTitle":1398,"acronym":1399,"eligibilityCriteria":1400,"healthyVolunteers":1396,"sex":1401,"minAge":1402,"maxAge":74,"enrollmentInfo":1403,"targetDuration":74,"studyType":1406,"phases":1407,"briefSummary":1409,"conditions":1410,"keywords":74,"overallStatus":202,"whyStopped":74,"lastUpdateSubmitDate":1414,"lastUpdatePostDateStruct":1415,"startDateStruct":1418,"completionDateStruct":1420,"leadSponsor":1422,"locationsCount":1423},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,15,22,30,36,43,49,53,58,64],{"label":9,"type":6,"description":10,"interventionNames":11},"Ultra-protective ventilation facilitated by extracorporeal carbon dioxide removal.","Patients randomized to the this intervention group will receive VV-ECMO with the ventilator set to minimize driving pressure and respiratory rate for ultra-protective ventilation.",[12,13,14],"Other: Ultra-Protective Ventilation Facilitated by Extracorporeal Support","Other: Lung-Protective Ventilation (LPV)","Other: VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation",{"label":16,"type":6,"description":17,"interventionNames":18},"Invasive Mechanical Ventilation (IMV) Strategies domain","Patients on invasive mechanical ventilation in the low elastance, high elastance, and ECLS states will be randomized to minimum of one of two mechanical ventilation interventions (including conventional lung-protective ventilation as a control group). Most sites will randomize patients to two arms (one of which is the control group, LPV). A subset of sites will randomize patients to all three or four arms.",[13,19,20,21],"Other: Driving Pressure-Limited Ventilation (DPL)","Other: Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)","Other: Electrical impedance tomography (EIT)",{"label":23,"type":6,"description":24,"interventionNames":25},"The Corticosteroid Early and Extended (CORT-E2) Randomized Controlled Trial domain","Patients with acute hypoxemic respiratory failure (AHRF) requiring invasive or non-invasive respiratory support will be randomized in the Early Cohort to receive corticosteroid or usual care without corticosteroids. Patients treated with corticosteroids who still require invasive or non-invasive respiratory support after 10 days will be randomized in the Extended Cohort to extending corticosteroid use or stopping corticosteroids after 10 days.",[26,27,28,29],"Drug: Early Cohort corticosteroid dose","Drug: Extended Cohort corticosteroid dose","Drug: Usual care without routine corticosteroids","Drug: Usual care without extending corticosteroids",{"label":31,"type":6,"description":32,"interventionNames":33},"The Nebulized Furosemide for the Treatment of Pulmonary Inflammation (FAST-3) domain","Patients with Respiratory Failure Secondary to Pulmonary Infection.",[34,35],"Drug: Drug 4 mL:","Drug: Drug 40 mg:",{"label":37,"type":6,"description":38,"interventionNames":39},"The Invasive Mechanical Ventilation Strategies in Venovenous-Extracorporeal Life Support (IMV-ECLS)","Patients with acute hypoxemic respiratory failure receiving extracorporeal life support will be randomized to one of three positive end-expiratory pressure (PEEP) strategies.",[40,41,42],"Other: PEEP-20","Other: PEEP-AOP","Other: PEEP-10",{"label":44,"type":6,"description":45,"interventionNames":46},"The Fludrocortisone in Acute Hypoxemic Respiratory Failure with Airspace Disease (FLUDRO-1) domain","Patients with acute hypoxemic respiratory failure with airspace disease will be randomized to usual care with or without fludrocortisone.",[47,48],"Drug: Usual care with fludrocortisone","Drug: Usual care without fludrocortisone",{"label":50,"type":6,"description":51,"interventionNames":52},"VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation","Patients with acute hypoxemic respiratory failure in the high elastance state will be randomized to ultra-protective ventilation facilitated by extracorporeal carbon dioxide removal or to VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation or to conventional lung-protective ventilation.",[12,13,14],{"label":54,"type":6,"description":55,"interventionNames":56},"Evaluating Subphenotypes in Immunocompromized Patients with ARF (ESCAPE) Domain","We will conduct a prospective, multicenter, observational study (no treatment arm is involved) in 7 ICUs in Canada over 3 years. We will include adult patients (≥18 years) admitted to the ICU with AHRF who have an underlying immunocompromised condition.\n\nBiomarker Collection: Samples for serum biomarkers will be collected within 24 hours of fulfilling inclusion criteria, on days 0, 3 and 7. We will collect biomarkers associated with inflammatory conditions, epithelial injury, endothelial dysfunction and coagulation abnormalities - which have been shown to characterize lung injury or critical illness.\n\nData Collection: We will collect demographic, comorbidity, immunocompromised defining condition, clinical, respiratory physiology, and serum biomarker data for each patient.",[57],"Other: no treatment \u002F intervention arm is involved",{"label":59,"type":6,"description":60,"interventionNames":61},"Inspiratory Muscle Training in Patients Receiving Ongoing Mechanical Ventilation (IMPROV) Domain","This domain studies inspiratory muscle training (IMT) during and after mechanical ventilation in patients with acute hypoxemic respiratory failure (AHRF).",[62,63],"Other: Usual care","Other: Early Routine IMT",{"label":65,"type":6,"description":66,"interventionNames":67},"Clinical Implications of Potentially Injurious Patient-Ventilator Interactions (WAVEFORM) Domain","This domain primarily aims at understanding the short-and long-term clinical consequences of longitudinal exposure to abnormal patient ventilator interactions.",[68],"Other: no treatment \u002F intervention arm is involved.",[70,75,79,83,87,92,96,100,104,108,112,116,120,124,128,132,135,139,143,147,151],{"type":6,"name":71,"description":72,"armGroupLabels":73,"otherNames":74},"Ultra-Protective Ventilation Facilitated by Extracorporeal Support","Patients randomized to this intervention group will receive VV-ECMO with the ventilator set to minimize driving pressure and respiratory rate for ultra-protective ventilation.",[9,50],null,{"type":6,"name":76,"description":77,"armGroupLabels":78,"otherNames":74},"Lung-Protective Ventilation (LPV)","Patients randomized to LPV will receive standard of care lung-protective ventilation with conventional limits on tidal volume and plateau airway pressure.",[16,9,50],{"type":6,"name":80,"description":81,"armGroupLabels":82,"otherNames":74},"Driving Pressure-Limited Ventilation (DPL)","Patients randomized to DPL will receive mechanical ventilation set to maintain a safe limit on driving pressure and plateau airway pressure, without less for the tidal volume.",[16],{"type":6,"name":84,"description":85,"armGroupLabels":86,"otherNames":74},"Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)","Patients randomized to LDPVS will have ventilation and sedation adjusted to maintain lung-distending pressure and respiratory effort in a safe target range.",[16],{"type":88,"name":89,"description":90,"armGroupLabels":91,"otherNames":74},"DRUG","Early Cohort corticosteroid dose","Patients randomized to receive corticosteroids will receive dexamethasone 20mg daily for 5 days and then 10mg for an additional 5 days, for a total of 10 days from the time of randomization (or until ICU discharge or death, whichever comes first); after 10 days dexamethasone will be stopped without a taper.",[23],{"type":88,"name":93,"description":94,"armGroupLabels":95,"otherNames":74},"Extended Cohort corticosteroid dose","Patients randomized to receive extended corticosteroids will receive dexamethasone 10mg for an additional 10 days. At the end of the additional 10 days (day 20 of corticosteroids), the dexamethasone dose will be halved to 5mg for another 5 days (to reduce the risk of adrenal insufficiency) and then stopped (a total of 25 days or until ICU discharge or death, whichever comes first).",[23],{"type":88,"name":97,"description":98,"armGroupLabels":99,"otherNames":74},"Usual care without routine corticosteroids","Patients randomized to this arm will be managed according to usual care. They will receive corticosteroids only if prescribed by the clinician.",[23],{"type":88,"name":101,"description":102,"armGroupLabels":103,"otherNames":74},"Usual care without extending corticosteroids","Corticosteroids will stop after 10 days. Other management will be according to usual care. Patients will receive corticosteroids only if prescribed by the clinician.",[23],{"type":88,"name":105,"description":106,"armGroupLabels":107,"otherNames":74},"Usual care with fludrocortisone","Best practice standard of care prescribed by treating team + fludrocortisone 50μg enterally daily for 7 days.",[44],{"type":88,"name":109,"description":110,"armGroupLabels":111,"otherNames":74},"Usual care without fludrocortisone","Best practice standard of care prescribed by treating team without fludrocortisone. After randomization, if a clinical indication develops for fludrocortisone as part of standard of care, administration of fludrocortisone is not prohibited. Any fludrocortisone administered to participants in the control arm will be documented.",[44],{"type":88,"name":113,"description":114,"armGroupLabels":115,"otherNames":74},"Drug 4 mL:","4 mL of nebulized 0.9% saline minutes every 6 hours over 30 minutes every 6 hours.",[31],{"type":88,"name":117,"description":118,"armGroupLabels":119,"otherNames":74},"Drug 40 mg:","40 mg of nebulized furosemide in 4 mL of saline nebulized over 30 minutes every 6 hours",[31],{"type":6,"name":121,"description":122,"armGroupLabels":123,"otherNames":74},"PEEP-20","fixed high positive end-expiratory pressure at 20 cmH2O",[37],{"type":6,"name":125,"description":126,"armGroupLabels":127,"otherNames":74},"PEEP-AOP","positive end-expiratory pressure set according to airway opening pressure",[37],{"type":6,"name":129,"description":130,"armGroupLabels":131,"otherNames":74},"PEEP-10","fixed lower positive end-expiratory pressure at 10 cmH2O",[37],{"type":6,"name":50,"description":133,"armGroupLabels":134,"otherNames":74},"Patients randomized to this intervention group will receive VV-ECMO where the sedation will be reduced and the ventilator will will be adjusted to facilitate spontaneous breathing.",[9,50],{"type":6,"name":136,"description":137,"armGroupLabels":138,"otherNames":74},"Electrical impedance tomography (EIT)","Patients randomized to EIT will have PEEP titration compared via the Overdistension Collapse Intercept (ODCL) versus that obtained using a standard high PEEP table.",[16],{"type":6,"name":140,"description":141,"armGroupLabels":142,"otherNames":74},"no treatment \u002F intervention arm is involved","This trial is a prospective, multicenter, observational study (no treatment arm is involved).",[54],{"type":6,"name":144,"description":145,"armGroupLabels":146,"otherNames":74},"Usual care","Patients will be treated according to usual care.",[59],{"type":6,"name":148,"description":149,"armGroupLabels":150,"otherNames":74},"Early Routine IMT","* Training commences once patients meet readiness to wean criteria\n* 3 sets of 10 breaths, delivered twice daily using a device placed at the airway opening to apply an external resistive pressure load, until hospital discharge, death, or day 45 after randomization, whichever occurs first.\n* Device load will initially be set to 30% of the MIP.\n* Device load will be titrated upward (in increments of 5-10% of MIP, to a maximum of 60% of MIP) as needed to achieve a modified Borg dyspnea score of 7\u002F10 or visible accessory muscle use.",[59],{"type":6,"name":152,"description":141,"armGroupLabels":153,"otherNames":74},"no treatment \u002F intervention arm is involved.",[65],[155,158,160,163,165,168,171,174,177,179,181,183,186],{"name":156,"affiliation":5,"role":157},"Ewan Goligher, MD, PhD","STUDY_CHAIR",{"name":159,"affiliation":5,"role":157},"Eddy Fan, MD, PhD",{"name":161,"affiliation":5,"role":162},"Niall Ferguson, MD, MSc","PRINCIPAL_INVESTIGATOR",{"name":164,"affiliation":5,"role":162},"Lorenzo Del Sorbo, MD",{"name":166,"affiliation":167,"role":162},"Bram Rochwerg, MD, MSc","McMaster University",{"name":169,"affiliation":170,"role":162},"Bijan Teja, MD","Unity Health Toronto",{"name":172,"affiliation":173,"role":162},"John Muscedere, MD","Queens University",{"name":175,"affiliation":176,"role":162},"Laveena Munshi, MD","Mount Sinai Hospital, Canada",{"name":178,"affiliation":5,"role":162},"Dmitry Rozenberg, MD, PhD",{"name":180,"affiliation":167,"role":162},"Anastasia Newman, PhD",{"name":182,"affiliation":5,"role":162},"Irene Telias, MD, PhD",{"name":184,"affiliation":185,"role":162},"Andrea Castellvi Font, MD, PhD","Parc de Salut Mar, Spain",{"name":187,"affiliation":170,"role":162},"Laurent Brochard, MD",[189,195],{"name":190,"role":191,"phone":192,"phoneExt":193,"email":194},"Rongyu ( Cindy) Jin","CONTACT","4163404800","7613","rongyu.jin@uhn.ca",{"name":196,"role":191,"phone":197,"phoneExt":74,"email":198},"Cathy Chau","4167272260","cathy.chau@uhn.ca",[200,219,234,248,262,277,292,307,318,334,345,360,375,389,404,419,434,448,463,478,489,503,518,533,548,563,578,595,609,623,638,648,658,672,686,703,721,731,746,761,769,782,797,810,821,836,851,865,879,891,901,918,932,942,956,965,979,997,1011,1022,1037,1047,1061,1072,1086,1098,1121,1135,1150,1165,1180,1191,1207,1222,1236,1251,1267,1274,1286,1295,1301,1313,1321,1330,1339,1350,1360,1373,1383],{"facility":201,"status":202,"city":203,"state":204,"zip":205,"country":206,"countryCode":207,"cosmosGeoPoint":208,"geoPoint":213,"contacts":214},"University of Arizona","RECRUITING","Tucson","Arizona","85724","United States","US",{"type":209,"coordinates":210},"Point",[211,212],-110.92648,32.22174,{"lat":212,"lon":211},[215],{"name":216,"role":191,"phone":217,"phoneExt":74,"email":218},"Jarrod Mosier","520-626-6312","jmosier@aemrc.arizona.edu",{"facility":220,"status":202,"city":221,"state":222,"zip":223,"country":206,"countryCode":207,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"University of California Los Angeles (UCLA)","Los Angeles","California","90095",{"type":209,"coordinates":225},[226,227],-118.24368,34.05223,{"lat":227,"lon":226},[230],{"name":231,"role":191,"phone":232,"phoneExt":74,"email":233},"Steven Y. Chang","310-825-8061","sychang@mednet.ucla.edu",{"facility":235,"status":202,"city":236,"state":222,"zip":237,"country":206,"countryCode":207,"cosmosGeoPoint":238,"geoPoint":242,"contacts":243},"University of San Diego (UCSD)","San Diego","92121",{"type":209,"coordinates":239},[240,241],-117.16472,32.71571,{"lat":241,"lon":240},[244],{"name":245,"role":191,"phone":246,"phoneExt":74,"email":247},"Atul Malhotra","844-757-5337","amalhotra@health.ucsd.edu",{"facility":249,"status":202,"city":250,"state":222,"zip":251,"country":206,"countryCode":207,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"University of California San Francisco","San Francisco","94143",{"type":209,"coordinates":253},[254,255],-122.41942,37.77493,{"lat":255,"lon":254},[258],{"name":259,"role":191,"phone":260,"phoneExt":74,"email":261},"Michael Matthay","415-353-1206","michael.matthay@ucsf.edu",{"facility":263,"status":202,"city":264,"state":265,"zip":266,"country":206,"countryCode":207,"cosmosGeoPoint":267,"geoPoint":271,"contacts":272},"University of Colorado Hospital","Aurora","Colorado","80045",{"type":209,"coordinates":268},[269,270],-104.83192,39.72943,{"lat":270,"lon":269},[273],{"name":274,"role":191,"phone":275,"phoneExt":74,"email":276},"Neil Aggarwal","303-724-5375","neil.aggarwal@cuanschutz.edu",{"facility":278,"status":202,"city":279,"state":280,"zip":281,"country":206,"countryCode":207,"cosmosGeoPoint":282,"geoPoint":286,"contacts":287},"University of Kentucky","Lexington","Kentucky","40506",{"type":209,"coordinates":283},[284,285],-84.47772,37.98869,{"lat":285,"lon":284},[288],{"name":289,"role":191,"phone":290,"phoneExt":74,"email":291},"Anil Gopinath","859-257-1000","ago233@uky.edu",{"facility":293,"status":202,"city":294,"state":295,"zip":296,"country":206,"countryCode":207,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"University of Maryland Medical System","Baltimore","Maryland","21201",{"type":209,"coordinates":298},[299,300],-76.61219,39.29038,{"lat":300,"lon":299},[303],{"name":304,"role":191,"phone":305,"phoneExt":74,"email":306},"Carl Shanholtz","410-328-8141","cshanhol@medicine.umaryland.edu",{"facility":308,"status":202,"city":294,"state":295,"zip":309,"country":206,"countryCode":207,"cosmosGeoPoint":310,"geoPoint":312,"contacts":313},"The Johns Hopkins Medicine","21224",{"type":209,"coordinates":311},[299,300],{"lat":300,"lon":299},[314],{"name":315,"role":191,"phone":316,"phoneExt":74,"email":317},"Sarina Sahetya","410-955-5000","ssahetya@jhmi.edu",{"facility":319,"status":320,"city":321,"state":322,"zip":323,"country":206,"countryCode":207,"cosmosGeoPoint":324,"geoPoint":328,"contacts":329},"VA Ann Arbor Healthcare System","NOT_YET_RECRUITING","Ann Arbor","Michigan","48105",{"type":209,"coordinates":325},[326,327],-83.74088,42.27756,{"lat":327,"lon":326},[330],{"name":331,"role":191,"phone":332,"phoneExt":74,"email":333},"Jane C Deng","734-249-1048","jcdeng@umich.edu",{"facility":335,"status":202,"city":321,"state":322,"zip":336,"country":206,"countryCode":207,"cosmosGeoPoint":337,"geoPoint":339,"contacts":340},"University of Michigan Health","48109",{"type":209,"coordinates":338},[326,327],{"lat":327,"lon":326},[341],{"name":342,"role":191,"phone":343,"phoneExt":74,"email":344},"Robert C Hyzy","888-287-1084","rhyzy@med.umich.edu",{"facility":346,"status":202,"city":347,"state":348,"zip":349,"country":206,"countryCode":207,"cosmosGeoPoint":350,"geoPoint":354,"contacts":355},"Washington University","St Louis","Missouri","63130",{"type":209,"coordinates":351},[352,353],-90.19789,38.62727,{"lat":353,"lon":352},[356],{"name":357,"role":191,"phone":358,"phoneExt":74,"email":359},"Pratik Sinha","314-273-3461","p.sinha@wustl.edu",{"facility":361,"status":202,"city":362,"state":363,"zip":364,"country":206,"countryCode":207,"cosmosGeoPoint":365,"geoPoint":369,"contacts":370},"University of Nebraska Medical Center","Omaha","Nebraska","68198",{"type":209,"coordinates":366},[367,368],-95.94043,41.25626,{"lat":368,"lon":367},[371],{"name":372,"role":191,"phone":373,"phoneExt":74,"email":374},"Keely Buesing","402-599-8908","keely.buesing@unmc.edu",{"facility":376,"status":202,"city":377,"state":377,"zip":378,"country":206,"countryCode":207,"cosmosGeoPoint":379,"geoPoint":383,"contacts":384},"Mount Sinai New York City","New York","10029",{"type":209,"coordinates":380},[381,382],-74.00597,40.71427,{"lat":382,"lon":381},[385],{"name":386,"role":191,"phone":387,"phoneExt":74,"email":388},"Neha N Goel","646-888-4298","neha.goel@mountsinai.org",{"facility":390,"status":202,"city":377,"state":377,"zip":391,"country":206,"countryCode":207,"cosmosGeoPoint":392,"geoPoint":394,"contacts":395},"Columbia University Irving Medical Center","10032",{"type":209,"coordinates":393},[381,382],{"lat":382,"lon":381},[396,400],{"name":397,"role":191,"phone":398,"phoneExt":74,"email":399},"Matthew R Baldwin","212-342-4676","mrb45@cumc.columbia.edu",{"name":401,"role":191,"phone":402,"phoneExt":74,"email":403},"Richard Greendyk","212-305-4141","richard.greendyk@uhn.ca",{"facility":405,"status":202,"city":406,"state":407,"zip":408,"country":206,"countryCode":207,"cosmosGeoPoint":409,"geoPoint":413,"contacts":414},"Wake Forest University School of Medicine","Winston-Salem","North Carolina","27101",{"type":209,"coordinates":410},[411,412],-80.24422,36.09986,{"lat":412,"lon":411},[415],{"name":416,"role":191,"phone":417,"phoneExt":74,"email":418},"Kevin Ward Gibbs","336-716-2011","kevin.gibbs@advocatehealth.org",{"facility":420,"status":202,"city":421,"state":422,"zip":423,"country":206,"countryCode":207,"cosmosGeoPoint":424,"geoPoint":428,"contacts":429},"University of Cincinnati College of Medicine","Cincinnati","Ohio","45267",{"type":209,"coordinates":425},[426,427],-84.51439,39.12711,{"lat":427,"lon":426},[430],{"name":431,"role":191,"phone":432,"phoneExt":74,"email":433},"Dina Gomaa","513-558-7333","gomaada@ucmail.uc.edu",{"facility":435,"status":202,"city":436,"state":422,"zip":437,"country":206,"countryCode":207,"cosmosGeoPoint":438,"geoPoint":442,"contacts":443},"Cleveland Clinic","Cleveland","44195",{"type":209,"coordinates":439},[440,441],-81.69541,41.4995,{"lat":441,"lon":440},[444],{"name":445,"role":191,"phone":446,"phoneExt":74,"email":447},"Abhijit Duggal","216-444-2200","duggala2@ccf.org",{"facility":449,"status":202,"city":450,"state":451,"zip":452,"country":206,"countryCode":207,"cosmosGeoPoint":453,"geoPoint":457,"contacts":458},"Oregon Health & Science University (OHSU)","Portland","Oregon","97239",{"type":209,"coordinates":454},[455,456],-122.67621,45.52345,{"lat":456,"lon":455},[459],{"name":460,"role":191,"phone":461,"phoneExt":74,"email":462},"Akram Khan","503-494-8311","khana@ohsu.edu",{"facility":464,"status":202,"city":465,"state":466,"zip":467,"country":206,"countryCode":207,"cosmosGeoPoint":468,"geoPoint":472,"contacts":473},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"type":209,"coordinates":469},[470,471],-75.16362,39.95238,{"lat":471,"lon":470},[474],{"name":475,"role":191,"phone":476,"phoneExt":74,"email":477},"John Reilly","630-790-1872","john.reilly@pennmedicine.upenn.edu",{"facility":479,"status":202,"city":465,"state":466,"zip":480,"country":206,"countryCode":207,"cosmosGeoPoint":481,"geoPoint":483,"contacts":484},"Thomas Jefferson University Hospital","19107",{"type":209,"coordinates":482},[470,471],{"lat":471,"lon":470},[485],{"name":486,"role":191,"phone":487,"phoneExt":74,"email":488},"Michael Baram","215-955-5161","michael.baram@jefferson.edu",{"facility":490,"status":202,"city":491,"state":466,"zip":492,"country":206,"countryCode":207,"cosmosGeoPoint":493,"geoPoint":497,"contacts":498},"University of Pittsburgh Medical Center (UPMC)","Pittsburgh","15213",{"type":209,"coordinates":494},[495,496],-79.99589,40.44062,{"lat":496,"lon":495},[499],{"name":500,"role":191,"phone":501,"phoneExt":74,"email":502},"Bryan McVerry","412-624-8905","Bryan.Mcverry@va.gov",{"facility":504,"status":202,"city":505,"state":506,"zip":507,"country":206,"countryCode":207,"cosmosGeoPoint":508,"geoPoint":512,"contacts":513},"Rhode Island Hospital","Providence","Rhode Island","02903",{"type":209,"coordinates":509},[510,511],-71.41283,41.82399,{"lat":511,"lon":510},[514],{"name":515,"role":191,"phone":516,"phoneExt":74,"email":517},"Maya Cohen","401-444-5773","maya_cohen@brown.edu",{"facility":519,"status":202,"city":520,"state":521,"zip":522,"country":206,"countryCode":207,"cosmosGeoPoint":523,"geoPoint":527,"contacts":528},"Medical University of South Carolina (MUSC)","Charleston","South Carolina","29425",{"type":209,"coordinates":524},[525,526],-79.93275,32.77632,{"lat":526,"lon":525},[529],{"name":530,"role":191,"phone":531,"phoneExt":74,"email":532},"Andrew Goodwin","843-792-4728","goodwian@musc.edu",{"facility":534,"status":202,"city":535,"state":536,"zip":537,"country":206,"countryCode":207,"cosmosGeoPoint":538,"geoPoint":542,"contacts":543},"Vanderbilt university medical center","Nashville","Tennessee","37232",{"type":209,"coordinates":539},[540,541],-86.78444,36.16589,{"lat":541,"lon":540},[544],{"name":545,"role":191,"phone":546,"phoneExt":74,"email":547},"Kevin Seitz","615-322-5000","kevin.seitz@vumc.org",{"facility":549,"status":202,"city":550,"state":551,"zip":552,"country":206,"countryCode":207,"cosmosGeoPoint":553,"geoPoint":557,"contacts":558},"University of Utah Health","Farmington","Utah","84025",{"type":209,"coordinates":554},[555,556],-111.88744,40.9805,{"lat":556,"lon":555},[559],{"name":560,"role":191,"phone":561,"phoneExt":74,"email":562},"Andrew 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3R9",{"type":209,"coordinates":1227},[1228,1229],-72.5477,46.34515,{"lat":1229,"lon":1228},[1232],{"name":1233,"role":191,"phone":1234,"phoneExt":74,"email":1235},"Jean-Francois Naud","450-687-8801","jean-francois.naud@inrs.ca",{"facility":1237,"status":202,"city":1238,"state":1239,"zip":1240,"country":691,"countryCode":692,"cosmosGeoPoint":1241,"geoPoint":1245,"contacts":1246},"University of Saskatchewan","Saskatoon","Saskatchewan","S7N 0W8",{"type":209,"coordinates":1242},[1243,1244],-106.66892,52.13238,{"lat":1244,"lon":1243},[1247],{"name":1248,"role":191,"phone":1249,"phoneExt":74,"email":1250},"Sabira Valiani","306-655-2035","svaliani@usask.ca",{"facility":1252,"status":202,"city":1253,"state":1254,"zip":74,"country":1255,"countryCode":1256,"cosmosGeoPoint":1257,"geoPoint":1261,"contacts":1262},"Clínica Universidad de La Sabana","Chía","Cundinamarca","Colombia","CO",{"type":209,"coordinates":1258},[1259,1260],-74.05866,4.85876,{"lat":1260,"lon":1259},[1263],{"name":1264,"role":191,"phone":1265,"phoneExt":74,"email":1266},"Luis Felipe Reyes","57-317-513-0128","luis.reyes5@unisabana.edu.co",{"facility":1268,"status":202,"city":1253,"state":1254,"zip":74,"country":1255,"countryCode":1256,"cosmosGeoPoint":1269,"geoPoint":1271,"contacts":1272},"Universidad de La Sabana",{"type":209,"coordinates":1270},[1259,1260],{"lat":1260,"lon":1259},[1273],{"name":1264,"role":191,"phone":1265,"phoneExt":74,"email":1266},{"facility":1275,"status":202,"city":1276,"state":1277,"zip":1278,"country":1279,"countryCode":1280,"cosmosGeoPoint":1281,"geoPoint":1285,"contacts":74},"Azienda Socio-Sanitaria Territoriale Ovest Milanese","Legnano","MI","20025","Italy","IT",{"type":209,"coordinates":1282},[1283,1284],8.91506,45.59788,{"lat":1284,"lon":1283},{"facility":1287,"status":202,"city":1288,"state":1277,"zip":1289,"country":1279,"countryCode":1280,"cosmosGeoPoint":1290,"geoPoint":1294,"contacts":74},"Ospedale Maggiore, Fondazione IRCCS Ca Granda, Milano","Milan","20122",{"type":209,"coordinates":1291},[1292,1293],12.59836,42.78235,{"lat":1293,"lon":1292},{"facility":1296,"status":202,"city":1288,"state":1277,"zip":1297,"country":1279,"countryCode":1280,"cosmosGeoPoint":1298,"geoPoint":1300,"contacts":74},"ASST Grande Ospedale Metropolitano Niguarda","20162",{"type":209,"coordinates":1299},[1292,1293],{"lat":1293,"lon":1292},{"facility":1302,"status":202,"city":1303,"state":1304,"zip":1305,"country":1306,"countryCode":1307,"cosmosGeoPoint":1308,"geoPoint":1312,"contacts":74},"Auckland City Hospital","Grafton","Auckland","1023","New Zealand","NZ",{"type":209,"coordinates":1309},[1310,1311],174.76566,-36.86029,{"lat":1311,"lon":1310},{"facility":1314,"status":202,"city":1304,"state":74,"zip":1315,"country":1306,"countryCode":1307,"cosmosGeoPoint":1316,"geoPoint":1320,"contacts":74},"Middlemore Hospital","2025",{"type":209,"coordinates":1317},[1318,1319],174.76349,-36.84853,{"lat":1319,"lon":1318},{"facility":1322,"status":202,"city":1323,"state":74,"zip":1324,"country":1306,"countryCode":1307,"cosmosGeoPoint":1325,"geoPoint":1329,"contacts":74},"Taranaki Base Hospital","New Plymouth","4310",{"type":209,"coordinates":1326},[1327,1328],174.08333,-39.06667,{"lat":1328,"lon":1327},{"facility":1331,"status":202,"city":1332,"state":74,"zip":1333,"country":1306,"countryCode":1307,"cosmosGeoPoint":1334,"geoPoint":1338,"contacts":74},"Rotorua Hospital","Rotorua","3010",{"type":209,"coordinates":1335},[1336,1337],176.24516,-38.13874,{"lat":1337,"lon":1336},{"facility":1340,"status":202,"city":1341,"state":74,"zip":1342,"country":1343,"countryCode":1344,"cosmosGeoPoint":1345,"geoPoint":1349,"contacts":74},"King Abdulaziz Medical City- Riyadh","Riyadh","11426","Saudi Arabia","SA",{"type":209,"coordinates":1346},[1347,1348],46.72185,24.68773,{"lat":1348,"lon":1347},{"facility":1351,"status":202,"city":1352,"state":74,"zip":1353,"country":1352,"countryCode":1354,"cosmosGeoPoint":1355,"geoPoint":1359,"contacts":74},"National University of Singapore","Singapore","119077","SG",{"type":209,"coordinates":1356},[1357,1358],103.85007,1.28967,{"lat":1358,"lon":1357},{"facility":1361,"status":1362,"city":1363,"state":1364,"zip":1365,"country":1366,"countryCode":1367,"cosmosGeoPoint":1368,"geoPoint":1372,"contacts":74},"Parc Taulí University Hospital","ACTIVE_NOT_RECRUITING","Sabadell","Barcelona","08208","Spain","ES",{"type":209,"coordinates":1369},[1370,1371],2.10942,41.54329,{"lat":1371,"lon":1370},{"facility":1374,"status":320,"city":1375,"state":1376,"zip":1377,"country":1366,"countryCode":1367,"cosmosGeoPoint":1378,"geoPoint":1382,"contacts":74},"Hospital Universitario de Getafe","Getafe","Madrid","28905",{"type":209,"coordinates":1379},[1380,1381],-3.73295,40.30571,{"lat":1381,"lon":1380},{"facility":1384,"status":202,"city":1385,"state":74,"zip":1386,"country":1366,"countryCode":1367,"cosmosGeoPoint":1387,"geoPoint":1391,"contacts":74},"Hospital Josep Trueta (Girona)","Girona","17007",{"type":209,"coordinates":1388},[1389,1390],2.82493,41.98311,{"lat":1390,"lon":1389},{"type":1393,"investigatorFullName":74,"investigatorTitle":74,"investigatorAffiliation":74,"oldNameTitle":74,"oldOrganization":74},"SPONSOR","100473127","platform-of-randomized-adaptive-clinical-trials-in-critical-illness-100473127",false,"NCT05440851","Platform of Randomized Adaptive Clinical Trials in Critical Illness","PRACTICAL","PRACTICAL Platform Inclusion Criteria:\n\n1. Acute hypoxemic respiratory failure meeting all of the following criteria;\n\n   1. New or worsening respiratory symptoms developing within 2 weeks prior to the onset of need for oxygen or respiratory support\n   2. Receiving any of the following types of oxygen or respiratory support for at least 4 hours prior to the time of randomization; supplemental oxygen at 10 L\u002Fmin or higher, high flow nasal oxygen (at any flow rate), invasive ventilator support, extra-corporeal life support (ECLS), or non-invasive ventilator support\n   3. Minimum FiO2 ≥ 0.40 (for venturi mask, high flow nasal cannula, or invasive or non-invasive ventilation) or oxygen flow rate ≥10 L\u002Fmin on face mask for at least 4 hours at the time of evaluation for eligibility unless already on extra-corporeal life support\n2. Age ≥ 18 years\n3. Hypoxemia not primarily attributable to acute heart failure, fluid overload, or pulmonary embolism (PE)\n\nPRACTICAL Platform Exclusion Criteria:\n\n1. Extubation is planned or anticipated on the day of screening\n2. ICU discharged is planned or anticipated on the day of screening\n3. If the patient is moribund and deemed unlikely to survive 24 hours (as determined by the clinical team)\n4. If the patient is being transitioned to a fully palliative philosophy of care\n\nEXPAND-ECLS Domain Inclusion Criteria:\n\n1. Receiving invasive Endotracheal mechanical ventilation for ≤ 72 hours.5 days\n2. Early Moderate-severe hypoxemic respiratory failure with a PaO2\u002FFiO2≤150200 mmHg for at least 6 hours\n\nEXPAND-ECLS Domain Exclusion Criteria:\n\n1. Patients over 70 years of age.\n2. Currently receiving any form of ECLS (e.g., Venovenous, venoarterial, or hybrid configuration).\n3. Chronic hypercapnic respiratory failure defined as PaCO2 \\> 60 mmHg in the outpatient setting.\n4. Home mechanical ventilation (non-invasive ventilation or via tracheotomy) except for CPAP\u002FBiPAP used solely for sleep-disordered breathing.\n5. Actual body weight exceeding 1 kg per centimeter of height.\n6. More than 48 hours have passed since meeting inclusion criteria.\n7. Severe hypoxemia with PaO2\u002FFiO2 \\\u003C 80mmHg for \\> 6 hours at time of screening.\n8. Severe hypercapnic respiratory failure with pH \\\u003C 7.25 and PaCO2 \\> 60 mmHg for \\> 6 hours at time of screening.\n9. Expected mechanical ventilation duration \\\u003C 48 hours at time of screening.\n10. Confirmed diffuse alveolar hemorrhage from vasculitis.\n11. Contraindications to limited anticoagulation (e.g., active GI bleeding, bleeding diathesis).\n12. Previous hypersensitivity\u002Fanaphylactic reaction to heparin or heparin-induced thrombocytopenia\n13. Neurologic conditions at risk for or undergoing treatment for intracranial hypertension\n14. Underlying illness with life expectancy \\\u003C 1 year\n15. Pregnancy (due to unknown effects of PaCO2 changes on placental blood flow)\n16. Respiratory failure known or suspected to be caused by COVID-19.\n\nIMV Domain Inclusion Criteria:\n\n1. Intubated patients, not on ECLS, with low normalized respiratory elastance (\\\u003C2.5 cm H2O\u002F(ml\u002Fkg predicted body weight)) at the time of eligibility assessment OR\n2. Intubated patients, not on ECLS, with high normalized respiratory system elastance (≥2.5 cm H2O\u002F(ml\u002Fkg predicted body weight)) at the time of eligibility assessment OR\n3. FOR STUDY SITES PARTICIPATING IN THE LDPVS INTERVENTION: Patient is on ECLS at the time of eligibility assessment. Note: Patients in this state are only eligible for the LPV or LDPVS intervention\n4. FOR STUDY SITES PARTICPATING IN THE EIT INTERVENTION: PaO2\u002FFiO2 (if available) \\\u003C 200 mm Hg at randomization. If PaO2\u002FFiO2 has not been measured, SpO2 = 97% on FiO2 =60%.\n\nIMV Domain Exclusion Criteria:\n\n1. PaO2\u002FFiO2 \\>300 mm Hg or (S\u002FF \\>250, if PaO2\u002FFiO2 has not been measured) at the time of randomization\n2. Chronic hypercapnic respiratory failure defined as PaCO2\\>60mmHg in the outpatient setting\n3. Home mechanical ventilation (non-invasive ventilation or via tracheotomy), not including nocturnal CPAP applied by nasal or face mask or home tracheotomy if not ventilated\n4. Severe hypoxemia with PaO2\u002FFiO2\\\u003C80mmHg for \\>6 consecutive hours at the time of randomization\n5. Severe hypercapnic respiratory failure with pH\\\u003C7.25 and PaCO2\\>60mmHg for \\>6 consecutive hours at the time of randomization\n6. Anticipated duration of mechanical ventilation is \\\u003C48 hours from the time of screening\n7. Duration of mechanical ventilation during current ICU admission is \\>72 hours\n8. Previously diagnosed neuromuscular disorder\n9. Current diagnosis of severe acute brain injury (e.g. ischemic or hemorrhagic stroke, traumatic brain injury) with Glasgow Coma Scale ≤ 8\n10. Baseline weight prior to or at hospital admission less than 35 kilograms\n11. Receiving extracorporeal life support without continuous invasive mechanical ventilatory support\n\nCORT-E2 Domain Early Cohort Inclusion Criteria\n\n1. Within 72 hours of admission to an ICU\n2. New unilateral or bilateral airspace disease\n\nCORT-E2 Domain Early Domain Exclusion Criteria\n\n1. Receiving only low flow oxygen therapy less than or equal to 15L\u002Fmin\n2. Corticosteroid use during the 14 days prior to screening\n3. Existing indication for corticosteroids\n4. High suspicion for\u002For confirmed COVID infection\n5. Acute traumatic brain injury during the index hospital admission\n6. Allergy to dexamethasone\n\nCORT-E2 Domain Extended Cohort Inclusion Criteria\n\n1. Are admitted to an ICU\n2. Have already received 10 days of corticosteroid specifically for acute respiratory failure, this will include patients: (a) randomized to corticosteroid arm in Early Cohort, (b) patients with COVID receiving corticosteroids as standard of care , (c) and others who have received corticosteroids for AHRF\n3. Ongoing AHRF requiring HFNC, NIV (continuous positive airway pressure \\[CPAP\\] or bilevel) or invasive ventilation\n\nCORT-E2 Domain Extended Cohort Exclusion Criteria\n\n1. An alternate indication for ongoing corticosteroids\n2. Acute traumatic brain injury this hospital admission\n\nFLUDRO Domain Inclusion Criteria 1. Within 72 hours of admission to an ICU\n\nFLUDRO Domain Exclusion Criteria\n\n1. Known hypersensitivity to fludrocortisone\n2. An inability to receive fludrocortisone due to lack of enteral access\n3. An indication to prescribe fludrocortisone for a reason that is unrelated to a current episode of pneumonia or acute respiratory failure, such as Addison's disease\n4. Belief of the treating clinical team that study participation would not be in the best interest of the patient\n\nFAST-3 Domain Inclusion Criteria (must meet all 3 of the following)\n\n1. Patient is in a PRACTICAL eligible platform state and requires advanced respiratory support (ARS) defined as one of the following:\n\n   a. Invasive mechanical ventilation with FiO2 \\> 40% b. Non-Invasive Ventilation (\\> 4 hours consecutively with FiO2 \\> 40%) defined as: i. CPAP or BiPAP (any settings or interface) ii. HFNC (flow \\> 40 liter per minute)\n2. PaO2\u002FFiO2 \\\u003C 300 mm Hg or SpO2\u002FFiO2 \\\u003C 315 (if PaO2\u002FFiO2 unavailable due to lack of arterial blood gas at the time of screening). For SpO2\u002FFiO2, criteria are SpO2 ≤ 97% on FiO2 ≥ 40% on both of the 2 hours immediately preceding eligibility assessment. If an arterial blood gas can be obtained, then a PaO2\u002FFiO2 ratio is preferable.\n3. Patient commenced advanced respiratory support \\\u003C 48 hours prior to randomization.\n\nFAST-3 Domain Exclusion Criteria\n\n1. Patient commenced advanced respiratory support \\> 48 hours to time of randomization.\n2. Known history of severe chronic pulmonary disease e.g., pre-infection requirement for home oxygen therapy or presence of chronic hypercapnia (PaCO2 \\> 60 mmHg); mild - moderate disease is still eligible in the absence of chronic hypercapnia or need for chronic oxygen therapy.\n3. Currently enrolled in another trial studying investigational anti-inflammatory therapy, excluding established treatments used in clinical practice such as corticosteroids.\n4. Known allergy to furosemide or sulfonamide drugs. If the patient is allergic to sulfonamide drugs but has received in the past or is currently receiving furosemide without incident, they can be enrolled since cross-reactivity between furosemide and sulfonamide agents is rare.\n\nESCAPE Domain Inclusion Criteria\n\n1. Patients with severe AHRF who have an underlying immunocompromised condition\n2. Within 48 hours of fulfilling the AHRF inclusion criteria as well as PaO2\u002FFiO2 \\\u003C300 or a SaO2\u002FFiO2 \\\u003C 315 on non-invasive respiratory support (venturi mask, non-invasive ventilation or high flow nasal oxygen as per the FiO2 requirements above) or invasive ventilation.\n\nPatients may be enrolled from the wards or ICU.\n\nImmunocompromised patients include:\n\n1. Any patients requiring long term (\\>30 days) corticosteroids (\\>20 mg\u002Fday),\n2. Any patients receiving non-corticosteroid immunosuppressive medications within the prior 3 months,\n3. Acquired or inherited immunodeficiency syndrome,\n4. Recipients of solid organ transplant,\n5. Active hematologic malignancy (diagnosis or receiving treatment within prior 6 months),\n6. Active solid tumor (diagnosis or receiving treatment within the prior 6 months) or\n7. Any patients who have undergone allogeneic or autologous hematopoietic cell transplant in the prior 6 months (HCT).\n\n   ESCAPE Domain Exclusion Criteria\n   1. Patients whom are deemed palliative.\n\n   WAVEFORM Domain Inclusion Criteria\n\n   1\\. Patient is intubated at the time of eligibility assessment.\n\n   WAVEFORM Domain Exclusion Criteria\n   1. PaO2\u002FFiO2 \\>300 mm Hg or (S\u002FF \\>250, if PaO2\u002FFiO2 has not been measured) at the time of eligibility assessment.\n   2. Duration of mechanical ventilation during current ICU admission is ≥72 hours.\n   3. Receiving ECLS without continuous invasive mechanical ventilatory support.\n\n   IMV-ECLS Domain Inclusion Criteria\n\n   1\\. Patients with AHRF (as defined in platform inclusion criteria #1 above) who have been consented for cannulation for VV-ECLS or who have been initiated on VV-ECLS within 6 hours at the time of randomization\n\n   IMV-ECLS Domain Exclusion Criteria 1. Patients receiving ECLS for the primary intention of extracorporeal CO2 removal 2. Patients expected to be liberated from ECLS within \\\u003C24 hours 3. History of recent pneumothorax or pneumomediastinum (\\\u003C3 months at the time of eligibility assessment\u002Frandomization) 4. Patients receiving ECLS for the primary intention of bridge to lung transplantation (at the time of eligibility assessment\u002Frandomization)\n\n   IMPROV Domain Inclusion Criteria\n   1. Patients receiving invasive mechanical ventilation for AHRF as defined by the PRACTICAL platform trial criteria above.\n   2. Within 7 calendar days of intubation\n\n   IMPROV Domain Exclusion Criteria\n   1. Patient is expected to be liberated from mechanical ventilation within 24 hours\n   2. Known or suspected chronic hypercapnic respiratory failure defined as PaCO2\\>60mmHg in the outpatient setting\n   3. Home mechanical ventilation (non-invasive ventilation or via tracheotomy), not including nocturnal CPAP applied by nasal or face mask or home tracheotomy if not ventilated\n   4. Known pneumothorax or pneumomediastinum without chest tube placement sustained during current ICU admission\\* (re-confirm immediately prior to randomization)\n   5. Patient is admitted primarily for acute brain injury (stroke, traumatic brain injury, etc.)\n   6. Previously diagnosed chronic neuromuscular disorder\n   7. Patient has an implantable cardiac defibrillator or pacemaker\n   8. Planned to be transferred to another hospital before ICU discharge\n   9. Already receiving a regimen of inspiratory muscle training using external resistive device or diaphragm neurostimulation","ALL","18 Years",{"count":1404,"type":1405},6250,"ESTIMATED","INTERVENTIONAL",[1408],"NA","PRACTICAL is a randomized multifactorial adaptive platform trial for acute hypoxemic respiratory failure (AHRF). This platform trial will evaluate novel interventions for patients with AHRF across a range of severity states (i.e., not intubated, intubated with lower or higher respiratory system elastance, requiring extracorporeal life support) and across a range of investigational phases (i.e., preliminary mechanistic trials, full-scale clinical trials). AHRF is a common and life-threatening clinical syndrome affecting millions globally every year. Patients with AHRF are at high risk of death and long-term morbidity. Patients who require invasive mechanical ventilation are at risk of ventilator-induced lung injury and ventilator-induced diaphragm dysfunction. New treatments and treatment strategies are needed to improve outcomes for these very ill patients.\n\nUtilizing advances in Bayesian adaptive trial design, the platform will facilitate efficient yet rigorous testing of new treatments for AHRF, with a particular focus on mechanical ventilation strategies and extracorporeal life support techniques as well as pharmacological agents and new medical devices.\n\nThe platform is designed to enable evaluation of novel interventions at a variety of stages of investigation, including pilot and feasibility trials, trials focused on mechanistic surrogate endpoints for preliminary clinical evaluation, and full-scale clinical trials assessing the impact of interventions on patient-centered outcomes.\n\nA domain is defined as a set of interventions that are intended to act on specific mechanisms of injury using different variations of a common therapeutic strategy. A domain may also be a non-interventional study that addresses observational research questions by collecting specific data or outcomes that are not collected as part of other domains. Domains are intended to function independently of each other, allowing independent evaluation of multiple therapies and mechanistic pathways within the same patient.\n\nOnce feasibility is established, Bayesian adaptive statistical modelling will be used to evaluate treatment efficacy at regular interim adaptive analyses of the pre-specified outcomes for each intervention in each domain. These adaptive analyses will compute the posterior probabilities of superiority, futility, inferiority, or equivalence for pre-specified comparisons within domains. Each of these potential conclusions will be pre-defined prior to commencing the intervention trial. Decisions about trial results (e.g., concluding superiority or equivalence) will be based on pre-specified threshold values for posterior probability. The primary outcome of interest, the definitions for superiority, futility, etc. (i.e., the magnitude of treatment effect) and the threshold values of posterior probability required to reach conclusions for superiority, futility etc., will vary from intervention to intervention depending on the phase of investigation and the nature of the intervention being evaluated. All of these parameters will be pre-specified as part of the statistical design for each intervention trial.\n\nIn general, domains will be designed to evaluate treatment effect within four discrete clinical states: non-intubated patients, intubated patients with low respiratory system elastance (\\\u003C2.5 cm H2O\u002F(mL\u002Fkg)), intubated patients with high respiratory system elastance (≥2.5 cm H2O\u002F(mL\u002Fkg)), and patients requiring extracorporeal life support. Where appropriate, the model will specify dynamic borrowing between states to maximize statistical information available for trial conclusions. In this perpetual trial design, different interventions may be added or dropped over time.\n\nWhere possible, the platform will be embedded within existing data collection repositories to enable greater efficiency in outcome ascertainment. Standardized systems for acquiring both physiological and biological measurements are embedded in the platform, to be acquired at sites with appropriate training, expertise, and facilities to collect those measurements.",[1411,1412,1413],"Respiratory Insufficiency","Extracorporeal Membrane Oxygenation Complication","Mechanical Ventilation Pressure High","2026-05-01",{"date":1416,"type":1417},"2026-05-07","ACTUAL",{"date":1419,"type":1417},"2023-04-30",{"date":1421,"type":1405},"2027-03-31",{"name":5,"class":6},89]