[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635066":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":12,"collaborators":10,"id":16,"slug":17,"hasResults":18,"nctId":19,"briefTitle":20,"officialTitle":21,"acronym":10,"eligibilityCriteria":22,"healthyVolunteers":18,"sex":23,"minAge":24,"maxAge":10,"enrollmentInfo":25,"targetDuration":10,"studyType":28,"phases":10,"briefSummary":29,"conditions":30,"keywords":33,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"CKD Stage 3-5 with Pleural Effusion",null,"Adult patients (≥18 years old) with a confirmed diagnosis of Chronic Kidney Disease (CKD) Stages 3 through 5, including both pre-dialysis and dialysis-dependent patients, who present with a radiologically confirmed pleural effusion. Patients in this cohort will undergo an ultrasound-guided diagnostic thoracentesis alongside simultaneous serum laboratory testing. The collected pleural fluid and serum will be analyzed to classify the effusion (using Light's Criteria, abbreviated criteria, and SPAG) and to determine its underlying etiology.",{"type":13,"investigatorFullName":14,"investigatorTitle":15,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Abeer Hussien Mahmoud Abdelaziz","Resident at Chest Diseases Department, Assiut University","100635066","pleural-effusion-types-in-chronic-kidney-disease-100635066",false,"NCT07547852","Pleural Effusion Types in Chronic Kidney Disease","Transudative and Exudative Pleural Effusion in CKD Patients","Inclusion Criteria:\n\n* Adults aged ≥18 years of either sex\n* Confirmed diagnosis of CKD Stage 3-5 based on eGFR \\\u003C 60 mL\u002Fmin\u002F1.73 m² for ≥3 months, as per KDIGO 2012 guidelines\n* Radiologically confirmed pleural effusion on chest X-ray (CXR) or thoracic ultrasound\n* Patients on hemodialysis or peritoneal dialysis, as well as those not yet on dialysis (CKD Stage 3-5 pre-dialysis)\n* Willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Patients with Acute Kidney Injury (AKI) or acute-on-chronic kidney disease without prior CKD diagnosis\n* Trauma-related pleural effusion (hemothorax, chylothorax)\n* Known active malignancy with suspected malignant effusion\n* Patients with post-surgical or iatrogenic pleural effusion\n* Patients who refuse consent or are unable to undergo thoracentesis due to coagulopathy or other contraindications\n* Pregnancy","ALL","18 Years",{"count":26,"type":27},100,"ESTIMATED","OBSERVATIONAL","The purpose of this observational study is to understand the causes of pleural effusion (a buildup of fluid around the lungs) in patients with advanced Chronic Kidney Disease (CKD Stages 3 to 5). Pleural effusion is a common complication in kidney disease, but it can be caused by many different issues, such as simple fluid overload, heart failure, or infections like tuberculosis.\n\nTo treat this fluid buildup effectively, doctors need to classify whether the fluid is a transudate (usually caused by pressure imbalances like fluid overload) or an exudate (caused by inflammation, lung disease, or infection). Standard medical formulas, known as Light's Criteria, are typically used to figure this out by comparing proteins in the fluid to proteins in the blood. However, these standard tests may sometimes misclassify the fluid in kidney disease patients because their baseline blood protein and albumin levels are often altered by their condition.\n\nResearchers in this study will enroll adult CKD patients (both on dialysis and not yet on dialysis) who have confirmed fluid around their lungs. Participants will undergo a standard, ultrasound-guided procedure called a diagnostic thoracentesis to safely draw a small amount of the chest fluid. At the same time, a routine blood sample will be taken.\n\nThe study aims to:\n\n* Compare the chest fluid to the blood sample using standard criteria, abbreviated criteria, and the Serum-Pleural Effusion Albumin Gradient (SPAG).\n* Determine the most common underlying causes of lung fluid across different stages of kidney disease.\n* Identify which diagnostic formula is the most accurate for CKD patients, helping doctors avoid misdiagnosis and provide better, more targeted treatments.",[31,32],"Pleural Effusion","Chronic Kidney Disease",[34,35,36,37,38,39,40],"Light's Criteria","Serum-Pleural Effusion Albumin Gradient (SPAG)","Transudate","Exudate","Thoracentesis","Uremic Pleuritis","Hemodialysis","NOT_YET_RECRUITING","2026-04-17",{"date":44,"type":45},"2026-04-23","ACTUAL",{"date":47,"type":27},"2026-05",{"date":49,"type":27},"2027-06",{"name":5,"class":6}]