[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549461":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":18,"locations":29,"responsibleParty":49,"collaborators":18,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":18,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":18,"enrollmentInfo":62,"targetDuration":18,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":18,"overallStatus":32,"whyStopped":18,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Saline Irrigation Group","EXPERIMENTAL","Subjects will receive twice daily fibrinolytic therapy in addition to daily saline irrigation through their chest tube until the treating physician determines that the pleural space has been adequately evacuated",[13],"Procedure: Saline Irrigation",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care Group","NO_INTERVENTION","Subjects will receive twice daily fibrinolytic therapy through their chest tube until the treating physician determines that the pleural space has been adequately evacuated",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Saline Irrigation","250 cc waves of warmed saline irrigation (up to 2000 cc) through thoracostomy tube on a daily basis",[9],[26],{"name":27,"affiliation":5,"role":28},"Dagny Anderson, MD","PRINCIPAL_INVESTIGATOR",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-92.4699,44.02163,{"lat":42,"lon":41},[45],{"name":27,"role":46,"phone":47,"phoneExt":18,"email":48},"CONTACT","507-284-3104","anderson.dagny@mayo.edu",{"type":28,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Dagny K. Anderson","Principal Investigator","100549461","pleural-space-saline-irrigation-in-addition-to-standard-intrapleural-thrombolytic-therapy-in-empyemacomplicated-parapneumonic-effusion-100549461",false,"NCT06434324","Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema\u002FComplicated Parapneumonic Effusion","A Study to Evaluate the Efficacy of Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in the Management of Empyema\u002FComplicated Parapneumonic Effusion","Inclusion criteria:\n\n* Purulent pleural fluid versus pleural fluid analysis demonstrating pH \\\u003C7.2, glucose \\\u003C60 mg\u002FdL, positive Gram stain, or positive pleural fluid culture versus multiseptated pleural effusion with infection at top of differential diagnosis\n* Patients initiating intrapleural lytic therapy under the care of the Interventional Pulmonary consult service at Mayo Clinic in Rochester, MN\n\nExclusion Criteria:\n\n* Unwillingness to give informed consent\n* Patients with known bleeding diathesis\n* Platelet count \\\u003C50,000 per μL\n* INR \\>2.2 (of note, INR can be allowed to drift down or be reversed pharmacologically prior to initiation of intrapleural lytics\u002Fsaline)\n* Current use of systemic anticoagulation or antiplatelet therapy without the ability to hold therapy for the recommended amount of time prior to an invasive procedure (aspirin monotherapy is acceptable)\n* Pregnant or nursing females, or females of child-bearing potential who decline a pregnancy test prior to enrollment\n* Incarcerated patients\n* Presence of ipsilateral bronchopleural fistula\n* Current or recent (within past 30 days) presence of tunneled pleural catheter on the same side as the current proven\u002Fsuspected pleural space infection",true,"ALL","18 Years",{"count":63,"type":64},60,"ESTIMATED","INTERVENTIONAL",[67],"NA","The purpose of this study is to see if there is any benefit in adding saline irrigation through a chest tube to the standard course of treatment for people diagnosed or suspected of having a pleural space infection.",[70],"Pleural Infection","2026-03-24",{"date":73,"type":74},"2026-03-30","ACTUAL",{"date":76,"type":74},"2025-03-29",{"date":78,"type":64},"2027-03",{"name":5,"class":6},1]