[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584695":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":66,"collaborators":24,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":24,"enrollmentInfo":78,"targetDuration":24,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":24,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Icahn School of Medicine at Mount Sinai","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pleuroscopy first","ACTIVE_COMPARATOR","Participants will undergo pleuroscopy first",[13],"Procedure: Pleuroscopy first",{"label":15,"type":10,"description":16,"interventionNames":17},"Thoracentesis first","Participants will undergo thoracentesis first",[18],"Procedure: Thoracentesis first",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Pleuroscopies are performed under moderate sedation with local anesthesia. Through a 1-cm incision a camera is introduced into the pleural space and the space is inspected after draining all fluid. Targeted biopsies under direct visualization are obtained using forceps. The aspirated fluid and biopsies obtained are sent to the cytology and pathology laboratories for analysis.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Thoracenteses are performed under local anesthesia with the insertion of a 5-8Fr catheter into the pleural space. The aspirated fluid obtained is sent to the cytology laboratory for analysis.",[15],[29],{"name":30,"affiliation":31,"role":32},"Udit Chaddha, MBBS","MOUNT SINAI HOSPITAL","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","212-241-5900","udit.chaddha@mssm.edu",[39,54],{"facility":40,"status":41,"city":42,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Mount Sinai West","RECRUITING","New York","10019","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-74.00597,40.71427,{"lat":50,"lon":49},[53],{"name":30,"role":32,"phone":24,"phoneExt":24,"email":24},{"facility":55,"status":41,"city":42,"state":42,"zip":56,"country":44,"countryCode":45,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"Mount Sinai Hospital","10029",{"type":47,"coordinates":58},[49,50],{"lat":50,"lon":49},[61,62,65],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},{"name":63,"role":35,"phone":36,"phoneExt":24,"email":64},"Yekaterina Sherman, MD","yekaterina.sherman@mountsinai.edu",{"name":30,"role":32,"phone":24,"phoneExt":24,"email":24},{"type":32,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Udit Chaddha","Associate Professor of Medicine and Thoracic Surgery","100584695","pleuroscopy-first-versus-thoracentesis-first-in-patients-with-suspected-malignant-pleural-effusions-100584695",false,"NCT06892691","Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions","PERFECT-MPE","Inclusion Criteria:\n\n* Referral for diagnostic pleural procedure.\n* Age ≥ 18 years.\n* Suspected malignant pleural effusion (Suggestive radiologic appearance (based on computed tomography or positron emission tomography) OR suspected cancer with associated effusion.)\n\nExclusion Criteria:\n\n* Inability to provide informed consent.\n* Needs emergent drainage.\n* Pleural effusion is known to be malignant.\n* Suspected transudative, infectious or inflammatory effusion etiology.\n* Having prior inconclusive\u002Fnon-diagnostic thoracentesis or pleuroscopy.\n* Patient is deemed by the clinical team to be more appropriate for VATS biopsy.\n* Terminally ill patients in whom a diagnosis will not change management, or who is unlikely to be a candidate for oncological treatment due to significant comorbidities.\n* Pregnancy","ALL","18 Years",{"count":79,"type":80},98,"ESTIMATED","INTERVENTIONAL",[83],"NA","This is a randomized control trial of patients with suspected malignant pleural effusions to compare whether patients who have a thoracentesis or pleuroscopy (pleural biopsy) obtain an adequate biopsy, achieve a diagnosis, and begin cancer-directed therapy faster.",[86,87],"Pleural Effusion","Cancer","2026-02-02",{"date":90,"type":91},"2026-02-04","ACTUAL",{"date":93,"type":91},"2025-03-24",{"date":95,"type":80},"2026-09-17",{"name":5,"class":6},2]