[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584272":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":41,"locations":49,"responsibleParty":65,"collaborators":67,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":26,"maxAge":26,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":92,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Masaryk University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Arm","EXPERIMENTAL","* Echocardiography in index hospitalization (left ventricle ejection fraction, E\u002Fe' ratio, LAVi, TAPSE, peak systolic tricuspid annular velocity, peak tricuspid regurgitation velocity, estimated pulmonary artery systolic pressure)\n* Mini-Mental State Examination in index hospitalization in 65 years and older\n* Clinical examination, blood pressure, heart rate, oxygen saturation, ECG, height, weight, BMI, NYHA on every visit\n* KCCQ in first week visit and 12 months visit\n* Blood tests:\n\n  * NT-proBNP in index hospitalization and 12 months visit\n  * blood count, urea, creatinine, glycaemia and electrolytes on every visit\n* HF focused POCUS on every visit",[13],"Procedure: HF focused POCUS",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard care arm","ACTIVE_COMPARATOR","* Echocardiography in index hospitalization (left ventricle ejection fraction, E\u002Fe' ratio, LAVi, TAPSE, peak systolic tricuspid annular velocity, peak tricuspid regurgitation velocity, estimated pulmonary artery systolic pressure)\n* Mini-Mental State Examination in index hospitalization in 65 years and older\n* Clinical examination, blood pressure, heart rate, oxygen saturation, ECG, height, weight, BMI, NYHA on every visit\n* KCCQ in first-week visit and 12 months visit\n* Blood tests:\n\n  * NT-proBNP in index hospitalization and on every scheduled visit\n  * blood count, urea, creatinine, glycaemia and electrolytes on every visit",[19],"Procedure: Standard Care (in control arm)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","HF focused POCUS","* POCUS findings guide diuretic therapy adjustments by treating physicians\n* POCUS is performed with handheld device Vscan air SL® or Vscan extend®, GE Healthcare.\n* Sector probe and abdominal preset are used. Only B-mode is used.\n* The image depth is 15 cm or more to evaluate the structures sufficiently.\n* Patient position is supine or semirecumbent. For the pleural effusion exam, the preferred position is sitting.\n\n  1. Lungs: Assessment of B-lines in midclavicular and midaxillary zones.\n  2. Pleural Effusion\n  3. Inferior Vena Cava\n  4. Ascites",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Care (in control arm)","Standard care assessment with NT-proBNP on every scheduled visit.",[15],[32,36,38],{"name":33,"affiliation":34,"role":35},"Ondrej Ludka, Prof.","Brno University Hospital","STUDY_CHAIR",{"name":33,"affiliation":34,"role":37},"STUDY_DIRECTOR",{"name":39,"affiliation":34,"role":40},"Adam Koudelka, MD","PRINCIPAL_INVESTIGATOR",[42,46],{"name":39,"role":43,"phone":44,"phoneExt":26,"email":45},"CONTACT","+420 532 231 873","koudelka.adam@fnbrno.cz",{"name":33,"role":43,"phone":47,"phoneExt":26,"email":48},"+420 532 231 976","ludka.ondrej@fnbrno.cz",[50],{"facility":51,"status":26,"city":52,"state":26,"zip":53,"country":54,"countryCode":26,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"University Hospital Brno","Brno","625 00","Czechia",{"type":56,"coordinates":57},"Point",[58,59],16.60796,49.19522,{"lat":59,"lon":58},[62,63,64],{"name":33,"role":43,"phone":47,"phoneExt":26,"email":48},{"name":39,"role":43,"phone":44,"phoneExt":26,"email":45},{"name":39,"role":40,"phone":26,"phoneExt":26,"email":26},{"type":66,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[68],{"name":34,"class":6},"100584272","point-of-care-ultrasound-in-chronic-heart-failure-100584272",false,"NCT06887179","Point-of-Care Ultrasound in Chronic Heart Failure","The Role of Point-of-Care Ultrasound in the Management of Chronic Heart Failure","POCUS-HF","Inclusion Criteria:\n\n* Patients after hospitalization for acute heart failure (AHF)\n* Symptoms (shortness of breath, oedema, decreased exercise tolerance, increase in abdominal circumference)\n* Clinical signs (jugular vein distention, hepatojugular reflux, third heart sound, wet lung crackles, pitting oedema) or signs of congestion on CT, X-ray or ultrasound\n* NT-proBNP \\>450 pg\u002FmL \\\u003C55 years old, \\>900 pg\u002FmL 55-75 years old, \\>1800 pg\u002FmL \\>75 years old\n* Increase in oral diuretic therapy or need for IV diuretics\n\nExclusion Criteria:\n\n* pregnancy or lactation\n* under 18 years of age,\n* current AHF due to a transient cause (Takotsubo syndrome, neurogenic myocardial stunning, septic cardiomyopathy, cardiac tamponade, pulmonary embolism with acute cor pulmonale, thyrotoxicosis, bradycardia \\\u003C40\u002Fmin)\n* planned surgical treatment of the HF cause, CRT implantation or valvular repair ≤ 30 days ago, STEMI or coronary angiography with PCI or CABG ≤ 30 days ago, untreated AV block III. and II. degree type 2, planned or previous heart transplantation, myocarditis ≤ 6 months ago, complex congenital heart disease, cardiac amyloidosis, hypertrophic and restrictive cardiomyopathy, constrictive pericarditis\n* BMI over 40 kg\u002Fm2, cognitive deficit with MMSE \\\u003C18 points, life expectancy \\\u003C 12 months, progressive oncological disease, chronic liver failure Child-Pugh C, chronic kidney disease with eGFR \\\u003C0.25 ml\u002Fs\n* current participation in another study or relative of investigators","ALL",{"count":79,"type":80},112,"ESTIMATED","INTERVENTIONAL",[83],"NA","This study aims to determine whether Point-of-Care Ultrasound (POCUS)-guided treatment is non-inferior to standard NT-proBNP-based care in ambulatory patients following hospitalization for heart failure (HF) over a 12-month follow-up period.",[86],"Cardiovascular Diseases",[88,89,90,91],"Heart failure","Diuretic therapy","Congestion","Point-of-Care Ultrasound","NOT_YET_RECRUITING","2025-03-20",{"date":95,"type":96},"2025-03-25","ACTUAL",{"date":98,"type":80},"2025-04-01",{"date":100,"type":80},"2029-12-31",{"name":5,"class":6},1]