[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644142":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":55,"collaborators":18,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Ljubljana","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Polarized Aerobic Training","EXPERIMENTAL","Participants will undergo a 6-week supervised polarized aerobic training programme performed three times weekly on a cycle ergometer, combining low-to-moderate-intensity continuous training and high-intensity interval training prescribed according to ventilatory thresholds obtained during cardiopulmonary exercise testing.",[13],"Behavioral: Polarized Aerobic Training",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-Exercising Control","NO_INTERVENTION","Participants will maintain their habitual sedentary lifestyle throughout the 6-week intervention period and will refrain from initiating structured exercise training. Habitual physical activity patterns will be monitored throughout the study period.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","Participants will undergo a 6-week supervised polarized aerobic training programme performed three times weekly on a cycle ergometer. The intervention will combine low-to-moderate-intensity continuous training and high-intensity interval training prescribed according to individual ventilatory thresholds determined during cardiopulmonary exercise testing. The weekly structure will include two high-intensity interval sessions and one continuous aerobic training session, thereby creating a polarized intensity distribution characterized by a predominance of low-intensity exercise and limited exposure to the moderate-intensity domain. Exercise intensity will be individualized using heart rate and power output targets, and all sessions will be supervised by trained personnel.",[9],[25],{"name":26,"affiliation":5,"role":27},"Armin Paravlić, PhD","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Gašper Tunšek, MSc","CONTACT","+38651302949","gasper.turnsek@fsp.uni-lj.si",{"name":26,"role":31,"phone":35,"phoneExt":18,"email":36},"+386015207840","armin.paravlic@fsp.uni-lj.si",[38],{"facility":39,"status":40,"city":41,"state":18,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of Ljubljana, Faculty of sport","RECRUITING","Ljubljana","1000","Slovenia","SI",{"type":46,"coordinates":47},"Point",[48,49],14.50513,46.05108,{"lat":49,"lon":48},[52],{"name":53,"role":31,"phone":54,"phoneExt":18,"email":33},"Gašper Turnšek, MSc","051302949",{"type":56,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100644142","polarized-aerobic-training-and-vascular-adaptations-in-apparently-healthy-individuals-100644142",false,"NCT07665632","Polarized Aerobic Training and Vascular Adaptations in Apparently Healthy Individuals","Adaptations of Vascular and Cardiorespiratory Function to a 6-week Polarized Aerobic Training Model in Apparently Healthy Individuals","ACT-ON-CHRONIC","Inclusion Criteria:\n\n* Men and women aged 30-50 years\n* Apparently healthy individuals without diagnosed cardiovascular, metabolic, or renal disease\n* Sedentary lifestyle verified using the Global Physical Activity Questionnaire (GPAQ) and current physical activity classification criteria\n* Ambulatory blood pressure values within the normotensive range (\\\u003C140 mmHg systolic and \\\u003C90 mmHg diastolic)\n* Body mass index (BMI) \\\u003C30 kg\u002Fm²\n* No regular participation in structured exercise training\n\nExclusion Criteria:\n\n* Ambulatory blood pressure values ≥140 mmHg systolic and\u002For ≥90 mmHg diastolic\n* Moderate or high physical activity level according to the Global Physical Activity Questionnaire (GPAQ)\n* Diagnosed chronic cardiovascular, metabolic, renal, respiratory, or other systemic disease\n* Use of prescribed medication influencing cardiovascular or metabolic function\n* Musculoskeletal injury of the lower extremities within the previous six months\n* Menopause\n* Absence of a regular menstrual cycle\n* Pregnancy\n* Current smoking or tobacco use",true,"ALL","30 Years","50 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","This randomized controlled trial will investigate the effects of a 6-week polarized aerobic training intervention on vascular and cardiorespiratory function in apparently healthy sedentary adults aged 30-50 years. Polarized training is characterized by a high proportion of low-intensity aerobic exercise combined with a smaller volume of high-intensity interval exercise, potentially providing complementary haemodynamic and physiological stimuli that support vascular adaptations and cardiovascular health. Although polarized training has been extensively studied in athletic populations, its effects on vascular function in sedentary adults remain insufficiently understood.\n\nThirty participants will be randomly assigned in a 1:1 ratio to either a supervised polarized aerobic training group or a non-exercising control group. The intervention will consist of a 6-week supervised cycle ergometer training program performed three times per week and prescribed according to individual ventilatory thresholds obtained during cardiopulmonary exercise testing. Training sessions will combine low-to-moderate-intensity continuous exercise and high-intensity interval exercise. Participants allocated to the control group will maintain their habitual sedentary lifestyle throughout the study period.\n\nThe primary outcome will be endothelial function assessed by brachial artery flow-mediated dilation. Secondary outcomes will include arterial stiffness assessed by pulse wave velocity, central haemodynamics, microvascular function, cardiorespiratory fitness, skeletal muscle function, pulmonary function, respiratory muscle strength, and circulating biomarkers related to vascular health. Outcome measures will be assessed at baseline and after completion of the 6-week intervention period. The findings of this study may improve understanding of vascular and systemic adaptations to polarized aerobic training and help inform future exercise-based strategies for cardiovascular risk reduction in apparently healthy sedentary adults.",[77],"Sedentary Lifestyle",[79,80,81,82,83],"Polarized training","Vascular function","Flow-mediated dilation","Pulse wave velocity","Randomized controlled trial","2026-06-17",{"date":86,"type":87},"2026-06-24","ACTUAL",{"date":89,"type":71},"2026-05-25",{"date":91,"type":71},"2027-12-20",{"name":5,"class":6},1]