[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639400":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":41,"collaborators":26,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":26,"enrollmentInfo":55,"targetDuration":26,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":72,"whyStopped":26,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":26},{"fullName":5,"class":6},"Clinica Dadlani","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Regenerative periodontal surgery using Regenfast® (hyaluronic acid + polynucleotides) with Bio-Oss®","EXPERIMENTAL","Name: Regenfast® + Bio-Oss® Intervention: Hyaluronic acid + polynucleotides (Regenfast®) combined with bovine bone graft (Bio-Oss®) Procedure: Applied during minimally invasive periodontal regenerative surgery",[13],"Procedure: Regenerative periodontal surgery using Regenfast® (hyaluronic acid + polynucleotides) with Bio-Oss® graft",{"label":15,"type":16,"description":17,"interventionNames":18},"Regenerative periodontal surgery using Emdogain® (enamel matrix derivative) with Bio-Oss®","ACTIVE_COMPARATOR","Name: Emdogain® + Bio-Oss® Intervention: Enamel matrix derivative proteins (Emdogain®) combined with bovine bone graft (Bio-Oss®) Procedure: Applied during minimally invasive periodontal regenerative surgery",[19],"Procedure: Regenerative periodontal surgery using Emdogain® (enamel matrix derivative) with Bio-Oss® graft",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Regenerative periodontal surgery using Regenfast® (hyaluronic acid + polynucleotides) with Bio-Oss® graft","Combination Product: using PAPILLA Preservation Flap + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA) REGENFAST+ Bio-Oss\n\n• A PNHA gel will be placed on the root surfaces and infra-bony defects, followed by a tension-free primary closure of the interdental papillae and of the mucoperiosteal flaps using 5-0 suture",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Regenerative periodontal surgery using Emdogain® (enamel matrix derivative) with Bio-Oss® graft","Procedure: Papilla Preservation Flap\n\n• A conservative access flap will be performed such as simplified papilla preservation flap (SPPF). Use of EDTA 24 %, EMDOGAIN AND BIO-OSS® suturing the flap by tension-free primary closure of the interdental papillae and of the mucoperiosteal using 5-0 suture",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Shashi Dadlani, Dentistry","CONTACT","+34629462321","dadlanishashi@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Gustavo Cabello Dominguez, Dentistry","+34625693980","info@clinicanexus.com",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Shashi Dadlani","Medical Director of Clinica Dadlani","100639400","polynucleotides-and-hyaluronic-acid-vs-enamel-matrix-proteins-in-the-treatment-of-intrabony-defects-100639400",false,"NCT07589959","Polynucleotides and Hyaluronic Acid vs Enamel Matrix Proteins in the Treatment of Intrabony Defects","Polynucleotides and Hyaluronic Acid vs Enamel Matrix Derivative Proteins in the Treatment of Intrabony Defects: A Randomized Controlled Clinical Trial","PN-HAVSEMPIND","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Non-smokers or light smokers (fewer than 10 cigarettes per day)\n* No diabetes or well-controlled diabetes\n* At least one infrabony periodontal defect ≥ 3 mm in depth\n* Periodontal pocket depth ≥ 6 mm at baseline (after initial treatment)\n* Full-mouth plaque and bleeding scores ≤ 20%, ≤15% at re-evaluation\n* Ability and willingness to attend follow-up visits for 1, 3, and 5 years\n* Teeth included in the study must be healthy from an endodontic point of view or properly root-treated\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Patients with weakened immune systems or significant systemic diseases\n* Heavy smokers (more than 10 cigarettes per day)\n* Full-mouth plaque or bleeding scores \\>20%, \\>15%\n* Current alcohol or drug abuse\n* Patients who have received periodontal treatment within the last 6 months\n* Patients unwilling or unable to attend follow-up visits required for the study","ALL","18 Years",{"count":56,"type":57},40,"ESTIMATED","INTERVENTIONAL",[60],"NA","The goal of this clinical trial is to compare two periodontal regenerative treatments in adults with Stage III or IV periodontitis and infrabony periodontal defects ≥3 mm.\n\nThe study aims to determine whether hyaluronic acid and polynucleotides (Regenfast®) combined with bovine bone graft material (Bio-Oss®) provides similar or improved periodontal regeneration compared with enamel matrix derivative proteins (Emdogain®) combined with Bio-Oss®.\n\nResearchers will evaluate:\n\n* Periodontal healing and bone regeneration\n* Changes in probing depth, clinical attachment level, gingival recession, and tooth mobility\n* Radiographic bone fill\n* Survival of treated teeth after 1, 3, and 5 years\n\nParticipants will:\n\n* Receive initial periodontal treatment and oral hygiene instruction\n* Undergo clinical and radiographic evaluation\n* Receive minimally invasive periodontal regenerative surgery under local anesthesia\n* Be randomly assigned to receive either Regenfast® + Bio-Oss® or Emdogain® + Bio-Oss®\n* Attend follow-up visits with periodontal examinations and radiographs over 5 years",[63,64,65,66],"Periodontal Bone Loss","Periodontal Defect","Periodontitis Stage III","Periodontitis Stage IV",[68,69,70,71],"Infrabony Periodontal Defects","Polynucleotides","Hyaluronic Acid","Enamel Matrix Proteins","NOT_YET_RECRUITING","2026-05-11",{"date":75,"type":76},"2026-05-15","ACTUAL",{"date":78,"type":57},"2026-05",{"date":80,"type":57},"2031-07-30",{"name":43,"class":6}]