[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629462":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":25,"locations":31,"responsibleParty":54,"collaborators":57,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":10,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Sheba Medical Center","OTHER_GOV",[8,13,16],{"label":9,"type":10,"description":10,"interventionNames":11},"TBI",null,[12],"Diagnostic Test: Virtual Reality pupillometry test",{"label":14,"type":10,"description":10,"interventionNames":15},"Healthy age- and gender-similar control",[12],{"label":17,"type":10,"description":10,"interventionNames":18},"Non-TBI trauma control",[12],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DIAGNOSTIC_TEST","Virtual Reality pupillometry test","A short (less than 10 minute) chromatic pupilloperimetry test administered via virtual reality (VR) goggles. Participants are exposed to brief, low-intensity chromatic light stimuli within the VR environment, designed to elicit pupillary responses without causing glare. Pupil size is monitored, enabling objective assessment of neural function and potential indicators of head trauma.",[14,17,9],[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Lori Gueta","CONTACT","+972527485888","Lori.Gueta@sheba.health.gov.il",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Tel Litwinsky","Tel Aviv (Gosh Dan)","608552621","Israel","IL",{"type":40,"coordinates":41},"Point",[42,43],34.84588,32.05096,{"lat":43,"lon":42},[46,49,51],{"name":47,"role":28,"phone":29,"phoneExt":10,"email":48},"Ifat Sher, PhD","Ifat.SherRosenthal@sheba.health.gov.il",{"name":10,"role":28,"phone":10,"phoneExt":10,"email":50},"Ygal.Rotenstreich@sheba.health.gov.il",{"name":52,"role":53,"phone":10,"phoneExt":10,"email":10},"Ygal Rotenstreich, MD","PRINCIPAL_INVESTIGATOR",{"type":53,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Dr. Ygal Rotenstreich","Head, Electrophysiology Clinic , Goldschleger Eye Institute, Sheba Medical Center",[58],{"name":59,"class":60},"Reichman University","OTHER","100629462","portable-vr-based-chromatic-pupilloperimeter-for-diagnosis-and-monitoring-of-traumatic-brain-injury-100629462",false,"NCT07474987","Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury","Development of a Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury","Inclusion Criteria:\n\n1. Male and female subjects\n2. Clear ocular media a\n\nTBI group:\n\n1. Combat-related mild to moderate TBI\n2. Have either elevated TBI-associated blood biomarkers (Abbott Allinity I, GFAP\u002F UCHL1) and\u002For initial trauma head CT positive for acute intracranial trauma\n\nNon-TBI Trauma group:\n\n1\\. Age- and gender-similar soldiers without TBI (defined as war-related injury who screen negative for TBI based on symptoms, blood, and\u002For head CT)\n\nExclusion Criteria:\n\n1. Neuropsychiatric diseases\n2. Any other neurodegenerative diseases\n3. History of stroke, epilepsy, head trauma, or head tumors\n4. Ocular disease or ocular surgery within the last six months",true,"ALL","18 Years","67 Years",{"count":73,"type":74},150,"ESTIMATED","OBSERVATIONAL","Accurate and non-invasive methods for objectively identifying and monitoring head injuries (such as a concussion) are still an unmet need. It is known that pupil constriction in response to light stimuli can reflect changes in neural activity in the brain and is associated with sleep disturbances.\n\nThe investigators aim to examine the feasibility of using virtual reality goggles for monitoring traumatic brain injury by analyzing the pupillary response to multifocal chromatic stimuli. The VR device was programmed to present brief, low-intensity light stimuli (without glare), while the headset's camera records the pupil's reaction.",[78,79,80],"Traumatic Brain Injury (TBI) Patients","Healthy Participants","Non-TBI Trauma","2026-03-28",{"date":83,"type":84},"2026-04-02","ACTUAL",{"date":86,"type":74},"2026-04-01",{"date":88,"type":74},"2027-12-31",{"name":5,"class":6},1]