[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577563":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":28,"responsibleParty":55,"collaborators":57,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":20,"enrollmentInfo":75,"targetDuration":20,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":88,"overallStatus":31,"whyStopped":20,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Centre Hospitalier Universitaire, Amiens","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Parkinson's disease","EXPERIMENTAL","Patients 18 years age or older with Parkinson's disease or essential tremor and tremor resistant to medical therapy with a contraindication to deep brain stimulation or refusal deep brain stimulation",[13],"Procedure: laser electrode",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","laser electrode","A laser electrode is implanted surgically in the ventral and inteermediary nucleus of the thalamus (VIM).",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":26,"email":27},"Michel LEFRANC, Pr","CONTACT","0322088950","33","lefranc.michel@chu-amiens.fr",[29],{"facility":30,"status":31,"city":32,"state":20,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"CHRU Amiens","RECRUITING","Salouël","80480","France","FR",{"type":37,"coordinates":38},"Point",[39,40],2.2434,49.86988,{"lat":40,"lon":39},[43,45,48,51,53],{"name":44,"role":24,"phone":25,"phoneExt":26,"email":27},"Michel Lefranc, Pr",{"name":46,"role":47,"phone":20,"phoneExt":20,"email":20},"Melissa Tir, MD","SUB_INVESTIGATOR",{"name":49,"role":50,"phone":20,"phoneExt":20,"email":20},"David MALTETE, Pr","PRINCIPAL_INVESTIGATOR",{"name":52,"role":50,"phone":20,"phoneExt":20,"email":20},"Claire THIRIEZ, MD",{"name":54,"role":50,"phone":20,"phoneExt":20,"email":20},"Jean-Claude BOUFFETEAU, MD",{"type":56,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[58,60,62],{"name":59,"class":6},"University Hospital, Rouen",{"name":61,"class":6},"University Hospital, Caen",{"name":63,"class":64},"Central Hospital Saint Quentin","OTHER_GOV","100577563","possibilities-of-use-mri-guided-laser-interstitial-thermal-therapy-in-medically-intractable-tremor-100577563",false,"NCT06799923","Possibilities of Use MRI-Guided Laser Interstitial Thermal Therapy in Medically Intractable Tremor","Possibilities of Use Magnetic Resonance Imaging (MRI)-Guided Laser Interstitial Thermal Therapy (LITT) in Treatment of Medically Intractable Tremor","PossibiLITT","Inclusion Criteria:\n\n* Patients 18 years age or older with Parkinson\\'s disease or essential tremor and tremor resistant to medical therapy with a contraindication to deep brain stimulation or refusal deep brain stimulation\n\nExclusion Criteria:\n\n* Contraindication to MRI\n* Contraindication to general anesthesia\n* Patient unable to give their free and informed consent because of cognitive or psychiatric disorders\n* Brain anatomical abnormalities not allowing intervention\n* Adults protected (guardianship, curators) or deprived of liberty.","ALL","18 Years",{"count":76,"type":77},15,"ESTIMATED","INTERVENTIONAL",[80],"NA","Medically intractable tremors are a common difficult clinical situation. Deep brain stimulation decreases Parkinson's disease tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies. Less invasive lesional brain surgery (thalamotomy) procedures by radio-surgery or MRI-guided focused ultrasound have emerged and have proven to be effective in these third-line indications. Recently, a new technology has emerged allowing the performance of minimally invasive lesion surgeries by MRI-Guided Laser Interstitial Thermal Therapy (MRIg-LITT). MRIg-LITT has been shown to be effective and safe in management of epilepsies and brain tumors. However, no study has evaluated MRIg-LITT for performing thalamotomy in medically intractable tremor.In a pilot study, the investigators propose to evaluate the effect and safety of unilateral thalamotomy by MRIg-LITT in the management of medically intractable tremor of parkinsonian or essential origin.",[83,84,85,86,87],"Laser Interstitial Thermal Therapy","Parkinson Disease","Essential Tremor","Movement Disorders","MRI",[89,84,85,86,87],"laser interstitial thermal therapy","2025-01-28",{"date":92,"type":93},"2025-01-29","ACTUAL",{"date":95,"type":93},"2024-08-01",{"date":97,"type":77},"2026-04",{"name":5,"class":6},1]