[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100302530":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":32,"locations":39,"responsibleParty":59,"collaborators":62,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":10,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Former concussed pro-athletes",null,"Biomarkers for detecting possible CTE invivo in former pro-athletes with multiple concussions: Imaging\u002Fblood\u002Fcerebrospinal fluid (CSF)\u002FPositron emission tomography (PET-)tau\u002Fmagnetic resonance imaging (MRI)\u002Fneuropsychological assessment.",[13],"Diagnostic Test: Biomarkers for detecting possible CTE invivo",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy controls","Active Comparator",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Biomarkers for detecting possible CTE invivo","Detection biomarkers for possible CTE: Imaging\u002Fblood\u002FCSF\u002FPET-tau\u002FMRI\u002Feuropsychological assessment",[9,15],[25,29],{"name":26,"affiliation":27,"role":28},"Maria Carmela Tartaglia, M.D","Toronto Western Hopsital,UHN;Tanz CRND","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":31,"role":28},"Charles H Tator, M.D","Toronto Western Hopsital,UHN",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Mozhgan Khodadadi, MA","CONTACT","416-603-5800","4025","Mozhgan.Khodadadi@uhn.ca",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Canadian Concussion Centre, Toronto Western Hospital, University Health Network","RECRUITING","Toronto","Ontario","M6J 3S3","Canada","CA",{"type":49,"coordinates":50},"Point",[51,52],-79.39864,43.70643,{"lat":52,"lon":51},[55,56,58],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},{"name":57,"role":28,"phone":10,"phoneExt":10,"email":10},"Maria C Tartaglia, M.D",{"name":30,"role":28,"phone":10,"phoneExt":10,"email":10},{"type":28,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Carmela Tartaglia","Marion and Gerald Soloway Professorship in Brain Injury and Concussion Research,Assistant Professor",[63],{"name":64,"class":6},"The Weston A. Price Foundation","100302530","post-concussion-syndrome-in-professional-athletes-a-multidisciplinary-study-100302530",false,"NCT03218332","Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study","Inclusion Criteria:\n\nfluent in English, and a history of multiple concussions , low exposures , or no concussions (Control group ). Determination of concussion exposure will be determined as follows: Previous concussion will be based on the player's recall of injury and defined as \"an injury resulting from a blow to the head that caused an alteration in mental status and one or more of the following symptoms: headache, nausea, vomiting, dizziness\u002Fbalance problems, fatigue, trouble sleeping, drowsiness, sensitivity to light or noise, blurred vision, difficulty remembering, and difficulty concentrating.\n\nExclusion Criteria:\n\nNeurological disorders prior to concussions (e.g.: seizure disorder); systemic illnesses known to affect the brain (e.g., diabetes and lupus); a history of psychotic disorder; known developmental disorders (e.g., attention deficit disorder, dyslexia); history of migraines; and, active engagement in litigation.",true,"MALE","25 Years","85 Years",{"count":76,"type":77},150,"ESTIMATED","OBSERVATIONAL","to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre Concussion Project at the Toronto Western Hospital with the consent and full knowledge of their families and doctors. However, it is possible to participate in the research without agreeing to a brain donation.\n\nThe Project Team is specifically attempting a clinical-MRI-brain tissue research analysis to determine the exact mechanism of the damage to brain tissue following repeated concussions. This condition is known as chronic traumatic encephalopathy (CTE), and shows an abnormal protein in the brain called tau-protein.",[81],"Chronic Traumatic Encephalopathy","2021-09-27",{"date":84,"type":85},"2021-09-29","ACTUAL",{"date":87,"type":85},"2011-07-04",{"date":89,"type":77},"2030-12-30",{"name":5,"class":6},1]