[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558567":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":40,"locations":48,"responsibleParty":65,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":51,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Autogenous partially demineralized dentin graft","EXPERIMENTAL","Following atraumatic tooth extraction, curettes will be used to remove granulation tissues, and the socket will be irrigated with sterile normal saline.Then the socket will be filled with Autogenous partially demineralized dentin graft (that will be prepared using tooth transformer device) followed by placement of a collagen membrane to cover the socket(The membrane will be shaped to extend 2-3 mm beyond the margins of the extraction socket and positioned just beneath the marginal mucosa) . Suturing technique will be a criss cross horizontal mattress to ensure that most of the grafting material is covered.",[13],"Biological: autogenous partially demineralized dentin graft",{"label":15,"type":16,"description":17,"interventionNames":18},"Xenograft","ACTIVE_COMPARATOR","Following atraumatic tooth extraction, curettes will be used to remove granulation tissues, and the socket will be irrigated with sterile normal saline.Then the socket will be filled with xenograft graft followed by placement of a collagen membrane to cover the socket.( The membrane will be shaped to extend 2-3 mm beyond the margins of the extraction socket and positioned just beneath the marginal mucosa) Suturing technique will be a criss cross horizontal mattress to ensure that most of the grafting material is covered.",[19],"Biological: Xenograft",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","autogenous partially demineralized dentin graft","tooth cleaning : form decay, tartar, soft tissue debris, fillings, cement then cut into fragments (5×5 mm) and inserted into the milling device (Tooth Transformer, Milan, Italy). A disposable box containing disposable liquid solutions will be inserted into the device to ensure the demineralization of the graft with 0.1 M hydrochloric acid, 10% hydrogen peroxide, and demineralized water as a wash.The decontamination of the granules will take place through UVA rays and ultrasounds, with temperature variations always lower than 43 ◦C to avoid damage to proteins. After 25 min, particle graft biomaterials will be obtained. The particles size will range from 815 µm with peaks up to 1110 µm.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Cortico-cancallous Bovine powder",[15],[31,34,37],{"name":32,"affiliation":5,"role":33},"Manal M Hosny, Professor","STUDY_DIRECTOR",{"name":35,"affiliation":5,"role":36},"Weam A El-Battawy, Ass. Prof.","STUDY_CHAIR",{"name":38,"affiliation":5,"role":39},"Riham A Alshikh Hani Alkurdee, Bachelor","PRINCIPAL_INVESTIGATOR",[41,45],{"name":38,"role":42,"phone":43,"phoneExt":26,"email":44},"CONTACT","+201021931950","riham.ahmad@dentistry.cu.edu.eg",{"name":46,"role":42,"phone":26,"phoneExt":26,"email":47},"Weam El-Battawy, Ass. Prof.","Weamelbattawy@dentistry.cu.edu.eg",[49],{"facility":50,"status":51,"city":52,"state":26,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Faculty of Dentistry Cairo University","RECRUITING","Cairo","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.24967,30.06263,{"lat":59,"lon":58},[62,64],{"name":38,"role":42,"phone":63,"phoneExt":26,"email":44},"01021931950",{"name":35,"role":42,"phone":26,"phoneExt":26,"email":47},{"type":39,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Riham Ahmad Alshiek Hani Alkurdee","principle investigator Riham Ahmad Master degree student, periodontology department, faculty of dentistry, Cairo University","100558567","post-extraction-alterations-following-ridge-preservation-in-the-esthetic-zone-using-partially-demineralized-autogenous-dentine-graft-versus-xenograft-100558567",false,"NCT06552793","Post Extraction Alterations Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft","Evaluation of Post Extraction Hard Tissue Alteration Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft: A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Patients with non-restorable teeth and Type II extraction socket in the esthetic zone indicated for extraction for periodontal, carious or traumatic reasons.\n* Healthy patients with adequate oral hygiene (bleeding on probing ≤20%; Plaque index ≤20%).\n* Adult patients above 18 years old.\n* Patients accept 6-months follow-up period and provide an informed consent.\n\nExclusion Criteria:\n\n* Heavy smokers (more than 10 cigarettes per day or an electronic cigarette dose of \\>6 mg\u002Fml of nicotine).\n* Patients reporting systemic conditions that may compromise healing or bone metabolism (eg: diabetes).\n* Patients with poor oral hygiene (bleeding on probing \\>20%; Plaque index \\>20%)\n* The presence of acute periapical infection.\n* The presence of severe periodontal destruction.",true,"ALL","18 Years","65 Years",{"count":80,"type":81},23,"ESTIMATED","INTERVENTIONAL",[84],"NA","the aim of this study is to establish if there are clinical, radio-graphical and histomorphometrical differences between using Partially Demineralized Dentin graft versus Xenograft in the esthetic zone. as a clinical application in alveolar bone regeneration procedures related to implant dentistry, including socket preservation, alveolar ridge augmentation, after tooth extraction in the esthetic zone. After extraction of non-restorable teeth in the esthetic zone, will ridge preservation with application of partially demineralized autogenous dentin graft produce less hard tissue changes compared to xenograft?\n\nThe initial therapy consists of periodontal treatment (phase I therapy) including supragingival scaling, subgingival debridement if needed, adjustment of faulty restoration and polishing. The mechanical plaque control instructions for each patient include brushing and interdental cleaning techniques. Flapless and atraumatic tooth extraction will be initiated, Then the sockets will be carefully packed with the allocated graft material that are shaped to match the individual size and contours of each socket. Once the grafts are properly adapted to the sockets, they will be covered with collagen membrane. The membrane will be shaped to extend 2-3 mm beyond the margins of the extraction socket and positioned just beneath the marginal mucosa. To ensure its stability, a cross-suture will be performed, securing the membrane in place.\n\nIntervention group: The socket will be filled with partially demineralized autogenous dentin graft Control group: The socket will be filled with xenograft . For both groups, All the subjects will be evaluated at pre-surgical, baseline and 6 months post surgical months for clinical parameters and baseline( immediate post-surgical and 6 months post-surgical . Outcomes: Change in radiographic horizontal ridge width at 1mm below the most coronal aspect of the crest , Change in radiographic horizontal ridge width at 3 and 5mm below the most coronal aspect of the crest,Change in radiographic buccal ridge height , Change in radiographic buccal ridge height ,Change in radiographic Palatal ridge height,Percentage of new vital bone formation,Percentage of residual bone graft,Implant Primary Stability.\n\nDetailed Description: This study aims to evaluate clinical, radiographic and histomorphometrica",[87],"Socket Preservation",[89,90,91,92],"socket preservation","ridge preservation","autogenoues partially demineralized dentin graft","xenograft","2024-08-10",{"date":95,"type":96},"2024-08-14","ACTUAL",{"date":98,"type":96},"2024-05-01",{"date":100,"type":81},"2025-02-01",{"name":5,"class":6},1]