[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557658":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":29,"locations":38,"responsibleParty":55,"collaborators":28,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":28,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":28,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":28,"overallStatus":41,"whyStopped":28,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Experiment 1 - episodic \u002F executive switch","EXPERIMENTAL","All enrolled participants will be asked to perform experiment 1, which is a cognitive task involving the switch between performing episodic memory decisions (e.g., \"did you eat fruit yesterday?\") and executive decisions (e.g. \"...does 5+3+8 = 17?\"). Participants will perform this computer-based task while electrical brain activity is recorded from the posterior cingulate cortex, hippocampus and prefrontal cortex. This task takes 18 minutes to complete.",[13],"Behavioral: Cognitive testing",{"label":15,"type":10,"description":16,"interventionNames":17},"Experiment 2 - executive decision task","All enrolled participants will be asked to perform experiment 2, which is a cognitive task involving reward-based decisions between two options. For each decision, the two options will differ in their risk and reward (e.g., 100% chance of 10 points vs. 30% chance of 50 points). Participants will perform this computer-based task while electrical brain activity is recorded from the posterior cingulate cortex, hippocampus and prefrontal cortex. This task takes 15 minutes to complete.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Experiment 3 - episodic decision task","All enrolled participants will be asked to perform experiment 3, which is a cognitive task involving memory-based decisions between two options (pictures of people). For each decision, the two pictures will differ in memory strength and reward (e.g., familiar picture for 10 points vs. unfamiliar picture 50 points). Memory strength for each picture will be defined by how many times the picture was previously shown (e.g., 2 vs. 10 presentations) prior to performing the memory decision task. Participants will perform this computer-based task while electrical brain activity is recorded from the posterior cingulate cortex, hippocampus and prefrontal cortex. This task takes 15 minutes to complete.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","Cognitive testing","Cognitive tasks testing executive and episodic based decisions, and the switching between these processes.",[9,15,19],null,[30,35],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},"Ilaina Edelstein","CONTACT","2156153525","Ilaina.Edelstein@Pennmedicine.upenn.edu",{"name":36,"role":32,"phone":33,"phoneExt":28,"email":37},"Brett Foster","Brett.Foster@Pennmedicine.upenn.edu",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hospital of the University of Pennsylvania - Pavilion","RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-75.16362,39.95238,{"lat":51,"lon":50},[54],{"name":31,"role":32,"phone":28,"phoneExt":28,"email":34},{"type":56,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100557658","posterior-cingulate-cortex-and-executive-control-of-episodic-memory-100557658",false,"NCT06540976","Posterior Cingulate Cortex and Executive Control of Episodic Memory","Inclusion Criteria:\n\n* All participants are patients undergoing invasive brain monitoring for epilepsy and will be asked to consent to participation in this basic science protocol (which is focused on the patient group but is not focused on the study of epilepsy).\n\nExclusion Criteria:\n\n* Individuals not undergoing invasive brain monitoring for epilepsy.\n* Individuals outside of the age range (18-50 yrs).\n* Individuals with cognitive impairment or intellectual difficulty.","ALL","18 Years","50 Years",{"count":67,"type":68},130,"ESTIMATED","INTERVENTIONAL",[71],"NA","This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior. The goal is to test how distinct subregions of the PCC differentially contribute to memory-based decisions (e.g., have I seen this picture before?). The ability to perform invasive studies of the human brain is through routine clinical monitoring of brain activity which occurs during the neurosurgical treatment of epilepsy. However, this project only focuses on the basic science of PCC and memory behavior. Specifically, the investigators will use single-0cell and population measures of brain activity to test a new theory of PCC function which focuses on the executive processes needed to support memory retrieval and memory-based decisions. By studying the PCC, a convergence zone of memory and executive brain systems, progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease (e.g., Alzheimer's disease) and multiple psychiatric conditions (e.g., schizophrenia) implicating PCC dysfunction.",[74],"Episodic Memory","2025-09-05",{"date":77,"type":78},"2025-09-12","ACTUAL",{"date":80,"type":78},"2023-01-18",{"date":82,"type":68},"2027-04-30",{"name":5,"class":6},1]