[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642820":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":156,"collaborators":25,"id":158,"slug":159,"hasResults":160,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":160,"sex":166,"minAge":167,"maxAge":25,"enrollmentInfo":168,"targetDuration":25,"studyType":171,"phases":172,"briefSummary":174,"conditions":175,"keywords":178,"overallStatus":183,"whyStopped":25,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":193},{"fullName":5,"class":6},"Shanghai Tong Ren Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PSB pacing","EXPERIMENTAL","Patients were randomly assigned to receive posterosuperior bundle pacing for atrial pacing during regular pacemaker implantation procedures.",[13],"Procedure: PSB pacing",{"label":15,"type":16,"description":17,"interventionNames":18},"RAA pacing","ACTIVE_COMPARATOR","Patients were randomly assigned to receive right atrial appendage pacing for atrial pacing during regular pacemaker implantation procedures.",[19],"Procedure: RAA pacing",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Atrial pacing lead implanted at the right atrial appendage. Left bundle branch area pacing will be applied if ventricular pacing is necessary.",[15],null,{"type":22,"name":9,"description":27,"armGroupLabels":28,"otherNames":25},"Atrial pacing lead implanted at the posterosuperior bundle region. Left bundle branch area pacing will be applied if ventricular pacing is necessary.",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Zhaohui Qiu","CONTACT","+862152039999","qzh3503@shtrhospital.com",[36,53,66,80,94,106,116,126,136,146],{"facility":37,"status":25,"city":38,"state":39,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"China Medical University affiliated AnQing Municipal Hospital","Anqing","Anhui","China","CN",{"type":43,"coordinates":44},"Point",[45,46],117.04723,30.51365,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":51,"phoneExt":25,"email":52},"Liangchuan Chen","+86 13956556381","aqslyy@163.com",{"facility":54,"status":25,"city":55,"state":39,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Tongling People's 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People's Hospital",{"type":43,"coordinates":119},[101,102],{"lat":102,"lon":101},[122],{"name":123,"role":32,"phone":124,"phoneExt":25,"email":125},"Zongqi Zhang","+86 18049827281","zqzhang_scdc@126.com",{"facility":127,"status":25,"city":96,"state":97,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":128,"geoPoint":130,"contacts":131},"Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital",{"type":43,"coordinates":129},[101,102],{"lat":102,"lon":101},[132],{"name":133,"role":32,"phone":134,"phoneExt":25,"email":135},"Yisheng Pan","+86 13817273883","shlygjyl@163.com",{"facility":137,"status":25,"city":96,"state":97,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":138,"geoPoint":140,"contacts":141},"Shanghai University of Traditional Chinese Medicine affiliated Putuo Hospital",{"type":43,"coordinates":139},[101,102],{"lat":102,"lon":101},[142],{"name":143,"role":32,"phone":144,"phoneExt":25,"email":145},"Zongjun Liu","+86 19821577439","lzj72@126.com",{"facility":147,"status":25,"city":96,"state":97,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":148,"geoPoint":150,"contacts":151},"Tongji University School of Medicine affiliated Tongji University",{"type":43,"coordinates":149},[101,102],{"lat":102,"lon":101},[152],{"name":153,"role":32,"phone":154,"phoneExt":25,"email":155},"Bing Sun","+86 13918324334","woowoocncn@163.com",{"type":157,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100642820","posterosuperior-bundle-pacing-for-prevention-of-atrial-fibrillation-in-patients-with-sinus-node-dysfunction-100642820",false,"NCT07645066","Posterosuperior Bundle Pacing for Prevention of Atrial Fibrillation in Patients With Sinus Node Dysfunction","A Prospective, Multicenter, Randomized Controlled Trial Evaluating the Effect of Posterosuperior Bundle Pacing on Atrial Fibrillation Prevention in Patients With Sinus Node Dysfunction","PSB-AF","Inclusion Criteria:\n\n* Age ≥18 years\n* Indication for permanent pacemaker implantation, including:\n* Sinus node dysfunction, defined as at least one of the following:\n* Symptomatic sinus bradycardia\n* Tachy-brady syndrome\n* Chronotropic incompetence\n* Sinus pause \u002F arrest\n* Atrioventricular block (if present); if ventricular pacing is required, left bundle branch area pacing is planned\n* Expected survival \\>1 year\n* Panned implantation of a device capable of detecting atrial high-rate episodes\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Persistent atrial fibrillation (AF) (\\>7 days), long-standing persistent AF, permanent AF, or prior atrioventricular node ablation\n* Prior cardiac implantable electronic device (CIED) requiring replacement, upgrade, or revision\n* Indication for cardioverter-defibrillator (ICD) or cardiac resynchronization therapy (CRT-D)\n* Prior cardiac surgery, severe hepatic or renal dysfunction, or other life-threatening systemic diseases\n* Acute myocardial infarction within 3 months before enrollment\n* Persistent left superior vena cava or dextrocardia\n* Pregnant or breastfeeding women, or women of childbearing potential not using effective contraception\n* Participation in another clinical trial that may interfere\n* Any condition that, in the opinion of the investigator, makes participation unsuitable","ALL","18 Years",{"count":169,"type":170},300,"ESTIMATED","INTERVENTIONAL",[173],"NA","This study aims to evaluate whether posterosuperior bundle (PSB) pacing reduces the incidence of atrial fibrillation (AF) in patients with sinus node dysfunction (SND) undergoing pacemaker implantation. Approximately 300 patients will be enrolled and randomized to receive atrial pacing at either the PSB region or the right atrial appendage (RAA). The primary endpoint is the occurrence of AF episodes lasting ≥6 minutes, as detected by device or surface electrocardiogram. Patients will be followed for up to 24 months.",[176,177],"Pacing Therapy","Cardiac Pacing",[179,180,181,182],"Posterosuperior bundle pacing","Right atrial appendage pacing","Physiological pacing","atrial pacing","NOT_YET_RECRUITING","2026-06-08",{"date":186,"type":187},"2026-06-12","ACTUAL",{"date":189,"type":170},"2026-06-01",{"date":191,"type":170},"2029-02-01",{"name":5,"class":6},10]