[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509833":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":37,"locations":45,"responsibleParty":127,"collaborators":130,"id":137,"slug":138,"hasResults":139,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":26,"eligibilityCriteria":143,"healthyVolunteers":139,"sex":144,"minAge":145,"maxAge":26,"enrollmentInfo":146,"targetDuration":26,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":26,"overallStatus":47,"whyStopped":26,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":165},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group (NIV with HFNC)","EXPERIMENTAL","Patients randomized to the intervention group will receive NIV alternating with HFNC for 24 hours after extubation",[13],"Device: Noninvasive ventilation alternating with high flow nasal cannula",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group (HFNC alone)","ACTIVE_COMPARATOR","Patients randomized to the intervention group will receive HFNC only for 24 hours after extubation",[19],"Device: High flow nasal cannula",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Noninvasive ventilation alternating with high flow nasal cannula","A total of 24 hours of prophylactic respiratory support will be provided using NIV alternating with HFNC with total NIV usage of 16 hours and HFNC usage of 8 hours.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"High flow nasal cannula","A total of 24 hours of prophylactic respiratory support will be provided using HFNC alone.",[15],[32,35],{"name":33,"affiliation":5,"role":34},"Ramandeep Kaur, PhD","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Babak Mokhlesi, MD",[38,42],{"name":33,"role":39,"phone":40,"phoneExt":26,"email":41},"CONTACT","3129478898","ramandeep_kaur@rush.edu",{"name":36,"role":39,"phone":43,"phoneExt":26,"email":44},"(312) 563-0843","babak_mokhlesi@rush.edu",[46,64,79,94,109],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Chicago","Illinois","60612","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-87.65005,41.85003,{"lat":57,"lon":56},[60,61,62,63],{"name":33,"role":39,"phone":26,"phoneExt":26,"email":41},{"name":36,"role":39,"phone":26,"phoneExt":26,"email":44},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"name":36,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":65,"status":66,"city":67,"state":49,"zip":68,"country":51,"countryCode":52,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Central DuPage Hospital","NOT_YET_RECRUITING","Winfield","60190",{"type":54,"coordinates":70},[71,72],-88.1609,41.8617,{"lat":72,"lon":71},[75,78],{"name":76,"role":39,"phone":26,"phoneExt":26,"email":77},"Ankeet Patel","Ankeet.Patel@nm.org",{"name":76,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":80,"status":47,"city":81,"state":82,"zip":83,"country":51,"countryCode":52,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"McGovern Medical School, The University of Texas Health Science Center","Houston","Texas","77030",{"type":54,"coordinates":85},[86,87],-95.36327,29.76328,{"lat":87,"lon":86},[90,93],{"name":91,"role":39,"phone":26,"phoneExt":26,"email":92},"Rosa M. Estrada-Y-Martin, MD","rosa.m.estrada.y.martin@uth.tmc.edu",{"name":91,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":95,"status":47,"city":96,"state":97,"zip":98,"country":51,"countryCode":52,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"type":54,"coordinates":100},[101,102],-87.90647,43.0389,{"lat":102,"lon":101},[105,108],{"name":106,"role":39,"phone":26,"phoneExt":26,"email":107},"Rahul Nanchal, MD","rnanchal@mcw.edu",{"name":106,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":110,"status":47,"city":111,"state":112,"zip":113,"country":114,"countryCode":115,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Hospital Civil Fray Antonio Alcalde","Guadalajara","Jalisco","44280","Mexico","MX",{"type":54,"coordinates":117},[118,119],-103.34749,20.67738,{"lat":119,"lon":118},[122,125],{"name":123,"role":39,"phone":26,"phoneExt":26,"email":124},"Miguel Ángel Ibarra Estrada","drmiguelibarra@hotmail.com",{"name":126,"role":34,"phone":26,"phoneExt":26,"email":26},"Miguel Ángel Ibarra Estrada, MD",{"type":34,"investigatorFullName":128,"investigatorTitle":129,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ramandeep Kaur","Principal Investigator",[131,133,134,136],{"name":132,"class":6},"Hospital Civil de Guadalajara",{"name":95,"class":6},{"name":135,"class":6},"The University of Texas Health Science Center, Houston",{"name":65,"class":6},"100509833","postextubation-use-of-noninvasive-respiratory-support-in-severely-obese-patients-100509833",false,"NCT05918575","Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients","A Randomized Controlled Trial of Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients","Inclusion Criteria:\n\n1. Adult, age ≥ 18 years old\n2. Receiving invasive mechanical ventilation for ≥24 hours\n3. BMI ≥40 kg\u002Fm2\n4. Undergoing planned extubation per treating team\n5. Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT)\n\nExclusion Criteria:\n\n1. Pregnant\n2. Use of extra-corporeal membrane oxygenation\n3. Chronic tracheostomy in place\n4. Unplanned or accidental extubation\n5. Terminal\u002Fcompassionate extubation\n6. Contraindication to NIV use\n7. Intubated because of an acute exacerbation of COPD\n8. Underlying neuromuscular disease\n9. No reintubation requested by patient\u002Ffamily\n10. Documented\u002Fknown history of chronic hypercapnic respiratory failure on home NIV (including bilevel PAP).\n11. Enrolled in any other outcome study\n12. Treating clinician feels that HFNC or NIV are either mandatory or contraindicated for a given patient","ALL","18 Years",{"count":147,"type":148},250,"ESTIMATED","INTERVENTIONAL",[151],"NA","Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.",[154,155],"Obesity, Morbid","Extubation Failure","2025-10-16",{"date":158,"type":159},"2025-10-20","ACTUAL",{"date":161,"type":159},"2023-07-10",{"date":163,"type":148},"2026-12-01",{"name":5,"class":6},5]