[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628144":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":27,"responsibleParty":41,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":73,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Tomas Bata Hospital, Czech Republic","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"General Anesthesia + Peripheral Nerve Block (CA + PNB)",null,"Patients undergoing total knee arthroplasty under general anesthesia combined with a peripheral nerve block. General anesthesia is induced using intravenous and inhalational agents. A peripheral nerve block (most commonly femoral or saphenous) is administered preoperatively to reduce postoperative pain and opioid requirements. This group represents a commonly used multimodal analgesic approach in routine clinical practice.",{"label":13,"type":10,"description":14,"interventionNames":10},"General Anesthesia + Epidural Catheter (CA + EDA)","Patients undergoing total knee arthroplasty under general anesthesia with an epidural catheter placed for intraoperative and postoperative analgesia. General anesthesia is induced using intravenous and inhalational agents. The epidural catheter allows continuous administration of analgesics and individualized dose adjustment to maintain postoperative pain control. This group represents a commonly used technique for providing extended regional analgesia following TKA.",{"label":16,"type":10,"description":17,"interventionNames":10},"Spinal Anesthesia + Peripheral Nerve Block (SA + PNB)","Patients undergoing total knee arthroplasty under spinal anesthesia supplemented with a peripheral nerve block. Spinal anesthesia is administered into the subarachnoid space to provide intraoperative analgesia. A peripheral nerve block (femoral or saphenous) is added to enhance postoperative pain control and reduce the need for systemic analgesics. This combination represents a commonly used multimodal analgesic strategy.",{"label":19,"type":10,"description":20,"interventionNames":10},"Spinal Anesthesia (SA)","Patients receiving spinal anesthesia alone without an additional peripheral nerve block. Spinal anesthesia provides sensory and motor blockade of the lower body during surgery. This group allows evaluation of postoperative pain and analgesic requirements in patients managed with spinal anesthesia as the sole regional technique.",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Klára Nekvindová, MD, Ph.D.","CONTACT","+420 577 552 111","nekvindova.klara@gmail.com",[28],{"facility":29,"status":10,"city":30,"state":10,"zip":31,"country":32,"countryCode":10,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Tomas Bata regional hospital","Zlín","76001","Czechia",{"type":34,"coordinates":35},"Point",[36,37],17.67065,49.22645,{"lat":37,"lon":36},[40],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":10},{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Klára Nekvindová","Clinical Research Lead, omas Bata Hospital","100628144","postoperative-pain-and-analgesic-use-after-total-knee-arthroplasty-100628144",false,"NCT07457814","Postoperative Pain and Analgesic Use After Total Knee Arthroplasty","Postoperative Pain and Analgesic Consumption in Patients Undergoing Total Knee Arthroplasty Under General Anesthesia With Peripheral Nerve Block Versus Spinal Anesthesia With Peripheral Nerve Block","Inclusion Criteria:\n\n* Age 18-100 years\n* Primary total knee arthroplasty (TKA)\n* ASA physical status I-III\n* Glasgow Coma Scale (GCS) score of 15\n* Ability to understand study procedures and provide informed consent\n* Ability to cooperate during pre-anesthetic evaluation\n* No severe sensory impairment (e.g., blindness, deafness)\n\nExclusion Criteria:\n\n* Revision or reoperation of TKA\n* ASA score IV or higher\n* Refusal to participate or inability to provide informed consent\n* GCS ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder\n* Chronic use of strong opioid analgesics\n* Neurological disease affecting pain perception or cooperation\n* Cognitive impairment or language barrier preventing questionnaire completion\n* Use of anesthesia techniques other than GA + PNB or SA + PNB (e.g., epidural anesthesia, local infiltration without PNB)",true,"ALL","18 Years","100 Years",{"count":57,"type":58},50,"ESTIMATED","OBSERVATIONAL","This prospective observational study evaluates postoperative pain intensity and analgesic consumption in patients undergoing total knee arthroplasty (TKA) under different anesthesia techniques. Patients receive either general anesthesia with peripheral nerve block, spinal anesthesia with peripheral nerve block, spinal anesthesia alone, or general anesthesia with an epidural catheter. Pain scores (NRS), analgesic use, adverse effects, patient satisfaction, and the need for therapeutic interventions are assessed during the first 48 hours after surgery. The study aims to identify differences in postoperative pain control and factors associated with hypotension and other complications.",[62,63,64],"Postoperative Pain After Total Knee Arthroplasty","Postoperative Pain","Analgesic Consumption",[66,63,67,64,68,69,70,71,72],"Total Knee Arthroplasty","Anesthesia Techniques","Epidural Analgesia","Opioid Use","General Anesthesia","Spinal Anesthesia","Pain Management","NOT_YET_RECRUITING","2026-03-04",{"date":76,"type":77},"2026-03-09","ACTUAL",{"date":79,"type":58},"2026-03-01",{"date":81,"type":58},"2027-06-15",{"name":5,"class":6},1]