[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554607":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":28,"locations":37,"responsibleParty":53,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":10,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":10,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Sohag University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (control group):",null,"patients with normal coronary angiography and normal postprandial triglycerides",[13],"Diagnostic Test: Postprandial triglyceride",{"label":15,"type":10,"description":16,"interventionNames":17},"Group II",": patients with abnormal coronary angiography and high level of postprandial triglycerides more than 200mg\u002Fdl. They will be divided into subgroups according to severity of coronary artery disease (mild, moderate and severe) according to (Syntax score)",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group III",": patients with abnormal coronary angiography and normal postprandial triglycerides.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","Postprandial triglyceride","impact of postprandial triglyceride level on coronary atherosclerosis",[9,15,19],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Fatma M Eissa, resident","CONTACT","01150754924","fatma_mdhy_post@med.sohag.edu.eg",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":10},"Ali M kassem, professor","01003459738",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Sohag university Hospital","RECRUITING","Sohag","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.69478,26.55695,{"lat":48,"lon":47},[51],{"name":52,"role":31,"phone":10,"phoneExt":10,"email":10},"Magdy M Amin, professor",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Fatma Madhy Eissa","resident internal medecine","100554607","postprandial-triglyceride-impact-on-coronary-atherosclerosis-in-non-diabetic-patient-in-sohag-university-hospital-100554607",false,"NCT06501287","Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patient in Sohag University Hospital","Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patient in Sohag University Hospital [NCT ID Not Yet Assigned]","Inclusion criteria includes CAD based on coronary angiography, laboratory and ECG evidence.\n\nExclusion criteria:\n\nPatients with other co-morbidities diseases, such as liver and kidney disorders and thyroid diseases. Diabetic patients.","ALL",{"count":66,"type":67},160,"ESTIMATED","OBSERVATIONAL","INTRODUCTION Cardiovascular diseases, including coronary artery disease (CAD), are the leading cause of mortality worldwide. Despite remarkable advancements in diagnostic and therapeutic approaches, CAD continues to pose formidable challenges. Atherosclerosis, characterized by the deposition of lipids, inflammatory cells, and fibrous tissue within the arterial walls, is the fundamental pathology underpinning CAD. Atherosclerosis development and progression are closely intertwined with lipid metabolism, particularly elevated levels of low-density lipoprotein cholesterol (LDL-C) and reduced levels of high-density lipoprotein cholesterol (HDL-C) \\*1+. However, emerging evidence suggests that postprandial triglyceride levels, the transient increase in triglycerides following a meal, may play a pivotal role in atherosclerotic processes \\*2+. Postprandial hypertriglyceridemia has been linked to various cardiovascular risk factors, including inflammation, endothelial dysfunction, oxidative stress, and altered hemostasis \\*3+. cardiovascular disease (CVD) causes death for 4 million subjects in Europe every year. It causes death for women \\*2.2 million (55%)+ than men \\*1.8 million (45%)+, and cardiovascular (CV) deaths under 65 years more prevalent in men (490 000 versus 193 000) \\*4+. Endothelial dysfunction was the main cause of vascular atherosclerosis. The damage of Endothelium cause lipids and macrophages accumulation (mostly lowdensity lipoprotein) in vessel injury site \\*5+. Lipids considered the major cause of atherosclerosis \\*6+. The increase of blood cholesterol (especially LDL) considered the main cause of the disease. High levels of triglycerides could be independent risk factor for coronary artery disease (CAD), particularly in women. Although, it was suggested that high level of density lipoproteins (HDLs) can prohibit these risk factors. Extensive examinations showed that lipid decrease the prevention of CAD in primary and secondary cases \\*7+. The level \\> 90% of total glyceride and\u002For LDL and level \\> 10% of HDL confirm dyslipidemia \\*8+",[71],"Coronary Atheroscleroses","2024-07-08",{"date":74,"type":75},"2024-07-15","ACTUAL",{"date":77,"type":75},"2024-05-01",{"date":79,"type":67},"2024-12-25",{"name":55,"class":6},1]