[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605541":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":26,"enrollmentInfo":63,"targetDuration":26,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":79,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Infirmerie Protestante de Lyon","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Postural Group: hemodynamic management using postural mobilization (+\u002F- noradrenaline)","EXPERIMENTAL","In order to manage hemodynamics, postural mobilization will be applied by raising legs passively up to a 45° angle prior to any drug use (noradrenaline). If passive leg raising is not sufficient, noradrenaline will be used to stabilize hemodynamics,.",[13],"Procedure: passive leg raising for hemodynamic management during open-heart coronary bypass grafting",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group: use of noradrenaline only (no postural mobilization)","ACTIVE_COMPARATOR","Noradrenaline will be used to manage hemodynamics. Passive leg raising will not be used in this group",[19],"Procedure: Use of Noradrenaline only in control group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","passive leg raising for hemodynamic management during open-heart coronary bypass grafting","Passive leg raising will be used in the experimental group in order to manage hemodynamics: legs will be raised to an angle of approx. 45°",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Use of Noradrenaline only in control group","Noradrenaline will be used for hemodynamic management. Passive leg raising will not be used in this group",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"SIESS","CONTACT","+33 426297927","recherche-clinique@infirmerie-protestante.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":26},"RECRUITING","Caluire-et-Cuire","Auvergne-Rhône-Alpes","69300","France","FR",{"type":46,"coordinates":47},"Point",[48,49],4.8464,45.79462,{"lat":49,"lon":48},{"type":52,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100605541","postural-mobilization-compared-to-noradrenaline-only-in-off-pump-cabg-surgery-100605541",false,"NCT07163858","Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery","Comparison of Hemodynamic Management by Postural Mobilization Versus Chemical Vasoconstriction Using Noradrenaline Exclusively in Off-pump Coronary Artery Bypass Graft Surgery: A Prospective, Randomized, Comparative, Single-center Study.","OPTICAB","Inclusion Criteria:\n\n* Adult patient\n* patient requiring isolated coronary bypass surgery\n* Elective procedure or medical emergency\n* First cardiac surgery\n* Patient with an EF ≥30%\n* Mandatory affiliation to a social security system\n* Signed informed consent form\n* Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure\n\nExclusion Criteria:\n\n* Contraindication to an inotropic substance (only NA will be used)\n* Contraindication to passive leg raising\n* Patient in a life-threatening emergency\n* History of cardiac surgery\n* Bilateral iliac or common femoral artery occlusion\n* EF \\\u003C 30%\n* Pregnancy and breastfeeding\n* Renal failure (GFR \\\u003C 40 ml\u002Fmin\u002F1.73 m²)\n* Patient with bilateral thigh amputation\n* Class III obesity BMI \\> 40 kg\u002Fm²","ALL","18 Years",{"count":64,"type":65},50,"ESTIMATED","INTERVENTIONAL",[68],"NA","This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+\u002F- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.",[71,72,73,74,75,76,77,78],"Coronary Artery Disease With Need for Bypass Surgery","Coronary Artery Disease(CAD)","Coronary Artery Bypass","Off Pump Coronary Artery Bypass Graft","Off Pump Coronary Artery Bypass Surgery","Hemodynamic Management","Hemodynamic Optimization","Noradrenaline",[80,81,82,83],"open-heart coronary bypass","passive leg raising","hemodynamic management","off-pump CABG surgery","2025-11-25",{"date":86,"type":87},"2025-12-03","ACTUAL",{"date":89,"type":87},"2025-10-06",{"date":91,"type":65},"2027-08",{"name":5,"class":6},1]