[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100487944":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":64,"collaborators":67,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":41,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":41,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":41,"overallStatus":48,"whyStopped":41,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Simon Fraser University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Counterpressure Maneuvers","EXPERIMENTAL","Counterpressure maneuver (CPM) trials will be performed in front of a neutral wall in silence to ensure that visual or auditory stimuli do not affect movement.\n\nCPM:\n\n* Leg crossing and muscle tensing: Legs are crossed while upright and lower body musculature is isometrically contracted (clinical)\n* Crouching: Participant crouches down resting weight on the balls of their feet, pressing calves against the back surface of the thighs (clinical)\n* Exaggerated anterior-posterior sway: Participant sways back and forth with feet planted on ground at a pace\u002Famplitude that is comfortable (discrete)\n* Gluteal clenching: Participant rhythmically tenses and relaxes the gluteal muscles at a pace\u002Fduration that is comfortable (discrete)\n\nParticipants serve as their own controls and complete both testing arms.",[13,14],"Behavioral: Counterpressure Maneuvers","Behavioral: Baseline Stand",{"label":16,"type":17,"description":18,"interventionNames":19},"Baseline Stand","SHAM_COMPARATOR","Participants will perform a sit-stand test, followed by 5-minutes of baseline (quiet) standing trial on a force platform while cardiorespiratory responses are recorded.\n\nSit-stand test: following 5-minutes of supine rest, the participant will be passively moved into the seated position. They will then be asked to actively move into the standing position.\n\nBaseline stand: immediately following the sit-stand test, the baseline trial will begin. Participants will stand quietly on the force platform for 5-minutes. This trial will be performed in front of a neutral wall in silence to ensure that visual or auditory stimuli do not affect their movement.\n\nParticipants serve as their own controls and complete both testing arms.",[13,14],[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Movements that can aid in delaying or preventing syncope by recruiting skeletal muscle pumping (via compression of major veins by contracting muscle to eject blood through cardiovascular circuit) and increased sympathetic drive (via sustaining an isometric muscle contraction). In this trial, we will be evaluating two clinically recommended isometric maneuvers (crouching, and leg crossing with muscle tensing) and two novel dynamic maneuvers that comprise discrete movement that the investigators have identified in prior work (exaggerated anterior-posterior postural sway, rhythmic gluteal clenching).",[16,9],[26],"Physical counter maneuvers, counter maneuvers,",{"type":22,"name":16,"description":28,"armGroupLabels":29,"otherNames":30},"Participants will stand quietly for 5-minutes on a force platform to allow the investigators to assess their typical response to orthostasis.",[16,9],[31],"Quiet standing",[33],{"name":34,"affiliation":5,"role":35},"Victoria E Claydon, PhD","PRINCIPAL_INVESTIGATOR",[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Erin L Williams, BSc","CONTACT","6048976372",null,"erin_williams_2@sfu.ca",{"name":34,"role":39,"phone":44,"phoneExt":41,"email":45},"778-782-8513","victoria_claydon@sfu.ca",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Burnaby","British Columbia","V5A1S6","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-122.95263,49.26636,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":63,"phoneExt":41,"email":45},"Victoria Claydon, PhD","07788588118",{"type":35,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Dr. Victoria Claydon","Professor",[68,70,72],{"name":69,"class":6},"Provincial Health Services Authority British Columbia",{"name":71,"class":6},"University of British Columbia",{"name":73,"class":6},"Natural Sciences and Engineering Research Council, Canada","100487944","postural-sway-and-counterpressure-maneuvers-for-pediatric-syncope-100487944",false,"NCT05633693","Postural Sway and Counterpressure Maneuvers for Pediatric Syncope","Impact of Postural Sway on Cardiovascular Control in Pediatric Patients With Syncope","Inclusion Criteria:\n\nWe are looking for English speaking pediatric patients aged 6-18 years with a diagnosis of recurrent fainting (at least two episodes of fainting with loss of consciousness or near loss of consciousness in the last year) of a vasovagal origin or associated with the postural orthostatic tachycardia syndrome (POTS) (as determined by a paediatric cardiologist) to take part in this study.\n\nExclusion Criteria:\n\nThose with a diagnosis of recurrent fainting accompanied by any of the following will not be eligible to take part:\n\nKnown history of:\n\n* Suspected or confirmed cardiac arrhythmia (e.g., Wolff-Parkinson-White, Long QT)\n* Traumatic head injury\n* New presentation of a seizure disorder OR epilepsy recurrence\n* Overdose or intoxication\n* Structural heart disease\n* Cardiovascular disease including hypertension, diabetes, or renal disease\n* Hypoglycemia\n* Physical and\u002For psychological disability that impact their ability to complete the tests\n\nFemale participants of childbearing age will be excluded if they are pregnant, or think they might be. Participants who are taking any cardiovascular acting medications, including treatment for cardiovascular disease, or medications for orthostatic syncope (e.g. fludrocortisone, slow-release sodium chloride, β-blockers, midodrine) will be excluded from the study.\n\nIn order to reduce the likelihood of transmission of COVID-19, participants will only be eligible to participate in the study if they have received full immunisation against COVID-19 according to current Health Canada guidelines. Accordingly, participants will be asked to provide evidence of their vaccination status in order to take part in the study.","ALL","6 Years","18 Years",{"count":85,"type":86},30,"ESTIMATED","INTERVENTIONAL",[89],"NA","The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gluteal muscle tensing in children who faint (N=20), as well as their height, weight, muscularity, and pubertal (Tanner) stage. Autonomic cardiovascular control will be measured using a Valsalva manoeuvre (expiration against a closed airway for 20 seconds) and a supine-stand test. The primary outcomes are noninvasive measures of cardiovascular responses to the maneuvers (blood pressure, cerebral blood flow, and stroke volume (volume of blood pumped per heartbeat). Comparisons will be made across levels of sex, diagnosis, Tanner stage, muscularity, height, and degree of autonomic control.",[92,93,94],"Syncope, Vasovagal","Postural Orthostatic Tachycardia Syndrome","Orthostatic Intolerance","2026-04-22",{"date":97,"type":98},"2026-04-23","ACTUAL",{"date":100,"type":98},"2023-04-17",{"date":102,"type":86},"2027-06",{"name":5,"class":6},1]