[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520857":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":32,"locations":41,"responsibleParty":61,"collaborators":65,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":18,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":44,"whyStopped":18,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Auburn University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Water and Potassium","EXPERIMENTAL","N=40, 20 males, 20 females. Following the two-week habitual run-in period, this group will receive 2000mg potassium supplementation\u002Fday for 14 days. This will be achieved by taking capsules filled with potassium chloride powder.",[13],"Dietary Supplement: Water and Potassium supplementation",{"label":15,"type":16,"description":17,"interventionNames":18},"Habitual consumption","NO_INTERVENTION","N=40, 20 males, 20 females. All participants will be monitored after two weeks of habitual water and potassium prior to being assigned into two weeks of water and potassium.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIETARY_SUPPLEMENT","Water and Potassium supplementation","All Participants will be given cases of water and instructed to drink at least an extra 1L per day. Additionally, participants will be given 2000 mg of potassium via potassium chloride powder.",[9],[26,30],{"name":27,"affiliation":28,"role":29},"Austin T Robinson, Ph.D.","Indiana University","STUDY_DIRECTOR",{"name":31,"affiliation":5,"role":29},"L. Bruce Gladden, Ph.D.",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":18,"email":37},"Nina L Stute, M.S.","CONTACT","9373071608","NLS0028@auburn.edu",{"name":39,"role":35,"phone":40,"phoneExt":18,"email":18},"Meral A Culver, M.S.","3017428813",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Kinesiology Building","RECRUITING","Auburn","Alabama","36849","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-85.48078,32.60986,{"lat":54,"lon":53},[57],{"name":58,"role":35,"phone":59,"phoneExt":18,"email":60},"Nina L Stute, MS","334-844-1619","nls0028@auburn.edu",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Austin Robinson","Associate Professor",[66],{"name":28,"class":6},"100520857","potassium-hydration-cardiovascular-and-kidney-study-phacks-100520857",false,"NCT06062017","Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs)","The Effects of Water and Potassium Supplementation on Cardiovascular and Kidney Function in Young Adults","PHACKs","Inclusion Criteria:\n\n* Between the ages of 18-30 years\n* Resting blood pressure no higher than 150\u002F90 mmHg\n* BMI below 35 kg\u002Fm2\n* Free of any metabolic disease (e.g., diabetes) kidney disease, pulmonary disorders (e.g., COPD), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer.\n\nExclusion Criteria:\n\n* Have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood.\n* Are currently pregnant or trying to become pregnant.\n* take any of the following medications that are contraindicated with potassium supplementation:\n* Renin-angiotensin-aldosterone system (RAAS) blockers: Candesartan , Eprosartan, Irbesartan, Losartan, Olmesartan, Telmisartan\n* Non -steroidal anti-inflammatory medications: Aspirin, Ibuprofen, Naproxen\n* Non-selective beta-blockers: Pindolol, Penbutolol, Oxprenolol, Propranolol, Nadolol, Sotalol, Timolol, Tertatolol\n* Calcineurin inhibitors: Cyclosporine\n* Heparin (or other blood thinning medications)",true,"ALL","18 Years","30 Years",{"count":80,"type":81},40,"ESTIMATED","INTERVENTIONAL",[84],"NA","Compared with White Adults, Non-Hispanic Black Adults are at an elevated risk of developing cardiovascular disease (CVD) and end stage chronic-kidney disease (CKD), two of the leading causes of death in the United States. Inadequate hydration status is associated with risk factors for both CVD and CKD. Prior data show that Black individuals are less likely to be adequately hydrated when compared with their White counterparts. Further, socioeconomic factors have been shown to influence hydration practices. Inadequate hydration influences certain hormones that regulate blood volume and impact blood pressure, but increasing potassium intake may provide some positive effects on normalizing these hormones and blood pressure. Black adults, in particular, are more likely to consume less potassium, have inadequate hydration, and tend to have higher blood pressure. As such, there is a critical need for effective strategies to address racial disparities in hydration and resultant health consequences; as well as establish the role of socioeconomic factors contributing to hydration. Therefore, the investigators are seeking to test the investigators' central hypothesis that water with a potassium supplement will improve hydration and cardiovascular health in young White adults (n = 20, 10 females, 10 males), and to a greater extent in young Black Adults (n = 20, 10 females, 10 males. The investigators will assess measures of blood pressure, arterial stiffness, and biomarkers in the urine and blood samples prior to and following a 14-day hydration intervention of 1) bottled water and 2) bottled water with potassium supplementation (2000mg potassium\u002Fday).",[87,88,89],"Blood Pressure","Hydration","Vascular Disease Risk",[91,88,92,93,94],"Racial disparities","Blood pressure","Vascular function","Potassium","2025-02-25",{"date":97,"type":98},"2025-02-27","ACTUAL",{"date":100,"type":98},"2024-11-06",{"date":102,"type":81},"2027-07",{"name":5,"class":6},1]