[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638967":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":47,"collaborators":49,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":20,"enrollmentInfo":64,"targetDuration":20,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":80,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University College, London","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Neuromuscular electrical stimulation (NMES) and home exercise programme","EXPERIMENTAL","Three month intervention programme of Neuromuscular electrical stimulation (NMES) and home exercise programme",[13],"Behavioral: Neuromuscular Electrical Stimulation and Home Exercise Programme",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Neuromuscular Electrical Stimulation and Home Exercise Programme","-Neuromuscular and Electrical Stimulation (NMES): All participants will undergo a NMES treatment programme designed to strengthen wrist and finger extensors. Participants and their carers will receive training in NMES set up from the research physiotherapist. Surface electrodes are placed over the motor points of extensor carpi radialis and extensor digitorum communis to produce wrist and finger extension simultaneously.\n\nHome exercise: We aim for all patients to perform the Graded Repetitive Arm Supplementary Program (GRASP) level 1 (for severely affected upper limbs) for a minimum of 60 minutes\u002Fday, 5 days\u002Fweek. Patients will be provided with an exercise book containing written and pictorial instructions for each exercise, and the kits contained inexpensive equipment to complete the exercises. Exercises included strengthening of the arm and hand, range of motion, and gross and fine motor skills.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Nick Ward, MD","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Professor Nick Ward, MD","CONTACT","+44 20 3448 3486","n.ward@ucl.ac.uk",{"name":32,"role":28,"phone":20,"phoneExt":20,"email":33},"Lisa Tedesco Triccas, PhD","l.triccas@ucl.ac.uk",[35],{"facility":36,"status":20,"city":37,"state":20,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":20},"University College London- Department of Clinical and Movement Neurosciences","London","WC1N 3BJ","United Kingdom","UK",{"type":42,"coordinates":43},"Point",[44,45],-0.12574,51.50853,{"lat":45,"lon":44},{"type":48,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[50,52],{"name":51,"class":6},"University College London Hospitals",{"name":53,"class":54},"National Hospital for Neurology and Neurosurgery, London","UNKNOWN","100638967","potential-for-recovery-of-voluntary-finger-extension-after-stroke-100638967",false,"NCT07592247","Potential for Recovery of Voluntary Finger Extension After Stroke","PROVES","Inclusion Criteria\n\n* Diagnosed with a Stroke \\>6 months previously\n* Medical Research Council (MRC) grade 0 or 1 in long finger extensors.\n\nExclusion Criteria\n\n* Presence of spasticity in any wrist\u002Ffinger flexors (including lumbricals) \\>2 on Modified Ashworth Scale\n* Unable to get hand flat on table top\n* Botulinum toxin to long finger or wrist flexors \\\u003C 24 weeks prior to pre-treatment assessment (i.e. effects should have worn off).","ALL","18 Years",{"count":65,"type":66},100,"ESTIMATED","INTERVENTIONAL",[69],"NA","Stroke patients with absent voluntary finger extension (VFE) 6-months after stroke are not expected to recover hand function. However, experience from the Queen Square Upper Limb neurorehabilitation service contradicts this view. In this study, we will identify the characteristics of those chronic stroke patients who regain previously absent VFE.\n\nHundred chronic stroke patients will be recruited with absent\u002Fnegligible VFE in an external pilot and feasibility study. Transcranial magnetic stimulation will be used to determine the functional integrity of descending white matter pathways. Corticospinal tract integrity to finger extensor muscles will be based on whether motor-evoked potentials are present (MEP+) or absent (MEP-). Reticulospinal tract activity will be assessed by measuring ipsilateral MEP amplitudes and the Start-React response.\n\nAll patients will then receive 3-months of neuromuscular electrical stimulation plus home exercise, designed to strengthen wrist\u002Ffinger extensors, reduce spasticity and increase corticospinal excitability. The primary outcome measure will be restoration of VFE.\n\nIt is predicted that VFE will be restored in MEP+ but not MEP- patients. MEP- patients will have higher reticulospinal tract activity associated with spasticity. Restoration of VFE will allow patients to engage in evidence-based upper limb training to improve function e.g. constraint induced movement therapy or repetitive task training.",[72],"Stroke",[74,75,76,77,78,79],"Upper limb","Finger extension","Neurophysiological mechanisms","Neurorehabilitation","Motor recovery","functional electrical stimulation","NOT_YET_RECRUITING","2026-05-13",{"date":83,"type":84},"2026-05-18","ACTUAL",{"date":86,"type":66},"2026-09-01",{"date":88,"type":66},"2029-09-01",{"name":5,"class":6},1]