[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100431557":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":32,"responsibleParty":56,"collaborators":58,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University Hospitals Coventry and Warwickshire NHS Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Diseased cardiac tissue",null,"Heart muscle or cells (cardiomyocytes) will be obtained from patients undergoing cardiac surgery, namely coronary artery bypass grafting or for severe valvular heart disease.",[13],"Other: In-vitro contractile fatigue protocol",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy cardiac tissue","Healthy donor hearts from deceased individuals that are not transplantable due to technical reasons",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"In-vitro contractile fatigue protocol","Using contractility assays for muscle slices or the work-loop assay for isolated heart cells, the tissue preparation will undergo a series of contraction and relaxation under varying levels of preload, afterload, stimulation frequency and under other experimental conditions such as drug-induced inotropism.",[9,15],[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Patrick Tran","CONTACT","02476964000","patricktranphd@gmail.com",{"name":25,"role":26,"phone":30,"phoneExt":10,"email":31},"+442476965689","patrick.tran2@uhcw.nhs.uk",[33],{"facility":34,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University Hospitals Coventry and Warwickshire","RECRUITING","Coventry","CV22DX","United Kingdom","UK",{"type":41,"coordinates":42},"Point",[43,44],-1.51217,52.40656,{"lat":44,"lon":43},[47,49,51,54],{"name":48,"role":26,"phone":10,"phoneExt":10,"email":10},"Ceri Jones",{"name":25,"role":50,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":52,"role":53,"phone":10,"phoneExt":10,"email":10},"Prithwish Banerjee","PRINCIPAL_INVESTIGATOR",{"name":55,"role":53,"phone":10,"phoneExt":10,"email":10},"Helen Maddock",{"type":57,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[59],{"name":60,"class":6},"Coventry University","100431557","power-myocardial-fatigue-study-a-biomechanical-assessment-of-contractility-of-human-myocardium-100431557",false,"NCT04899635","POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium","Profiling Biomechanical Responses and Workload of the Human Myocardium to Explore the Concept of Myocardial Fatigue and Reversibility","POWER","Inclusion Criteria:\n\n* All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study\n* Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative\n\nExclusion Criteria:\n\nThis criterion is kept to a minimum since the availability of human myocardial samples is finite and dependent on the limited number of patients undergoing cardiac surgery annually within the local hospital.\n\n* Patients who do not have the mental capacity to undergo the consent process\n* For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).","ALL","18 Years","85 Years",{"count":73,"type":74},100,"ESTIMATED","OBSERVATIONAL","To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.",[78,79,80,81],"Heart Failure","Fatigue; Muscle, Heart","Myocardial Dysfunction","Exhaustion; Heart",[83,84,85,86,87,88],"Myocardial Fatigue","Preload","Afterload","Cardiac Work-loop","Cardiomyocytes","Biomechanical model","2024-06-17",{"date":91,"type":92},"2024-06-18","ACTUAL",{"date":94,"type":92},"2021-08-03",{"date":96,"type":74},"2025-04-30",{"name":5,"class":6},1]