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Trust","Reading",{"type":68,"coordinates":1256},[1257,1258],-0.97113,51.45625,{"lat":1258,"lon":1257},[1261],{"name":1262,"role":52,"phone":25,"phoneExt":25,"email":25},"Bassam Alchi, Dr",{"facility":1264,"status":266,"city":1265,"state":25,"zip":25,"country":807,"countryCode":808,"cosmosGeoPoint":1266,"geoPoint":1270,"contacts":1271},"Mid and South Essex NHS Foundation Trust","Southend-on-Sea",{"type":68,"coordinates":1267},[1268,1269],0.71433,51.53782,{"lat":1269,"lon":1268},[1272],{"name":1273,"role":52,"phone":25,"phoneExt":25,"email":25},"Anthony Yin Keet Chan, Dr",{"facility":1275,"status":266,"city":1276,"state":25,"zip":25,"country":807,"countryCode":808,"cosmosGeoPoint":1277,"geoPoint":1281,"contacts":1282},"The Royal Wolverhampton NHS Trust","Wolverhampton",{"type":68,"coordinates":1278},[1279,1280],-2.12296,52.58547,{"lat":1280,"lon":1279},[1283],{"name":1284,"role":52,"phone":25,"phoneExt":25,"email":25},"Kay Tan, Dr",{"type":1286,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[1288,1290,1292,1293],{"name":1289,"class":6},"National Health and Medical Research Council, Australia",{"name":1291,"class":6},"Applied Health Research Centre",{"name":804,"class":6},{"name":41,"class":6},"100329735","pragmatic-randomised-trial-of-high-or-standard-phosphate-targets-in-end-stage-kidney-disease-phosphate-100329735",false,"NCT03573089","Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)","An Investigator-initiated, International, Multi-centre, Prospective, Randomized, Open-label, Parallel-group, Superiority, and Pragmatic Large Simple Trial (LST) to Determine Whether the Currently Recommended Strategy of Intensive Reduction of Serum Phosphate Concentration Towards the Normal Level Results in Significant Patient-centred Benefits in End-stage Kidney Disease (ESKD) Patients Receiving Dialysis.","PHOSPHATE","Inclusion Criteria:\n\n1. Age ≥45 years, or Age ≥18 years with diabetes,\n2. ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,\n3. Currently prescribed at least one phosphate-lowering medication at any dose\n4. Able to provide informed consent\n\nExclusion Criteria:\n\n1. Elective kidney transplantation scheduled,\n2. Concomitant major illness \u002F comorbidity that may result in death in the next 6 months in the view of the treating physician,\n3. Participation in an interventional study that is likely to affect serum phosphate concentration.","ALL","18 Years",{"count":1305,"type":1306},3600,"ESTIMATED","INTERVENTIONAL",[1309],"NA","During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.",[1312,1313],"Kidney Failure, Chronic","Hyperphosphatemia",[1315,1316,1317,1318,1319,1320,1313],"Renal dialysis","Randomised controlled trial","Bone markers","Cardiovascular risk factors","Phosphate lowering agent","End stage kidney disease","2025-06-29",{"date":1323,"type":1324},"2025-07-01","ACTUAL",{"date":1326,"type":1324},"2019-12-10",{"date":1328,"type":1306},"2028-12-31",{"name":5,"class":6},115]