[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625380":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":47,"collaborators":49,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Singapore General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Pre-hospital Targeted Temperature Management","EXPERIMENTAL","Eligible out-of-hospital cardiac arrest (OHCA) patients who achieve return of spontaneous circulation (ROSC) and meet inclusion criteria will receive early targeted temperature management (TTM) initiated in the pre-hospital setting by Singapore Civil Defence Force (SCDF) paramedics. Cooling is delivered using the CarbonCool® surface cooling vest, applied immediately after ROSC and maintained during transport to the receiving hospital. Upon hospital arrival, a 1-for-1 vest exchange is performed in the Emergency Department before continuation of standard post-cardiac arrest care.",[13],"Device: CarbonCool® Cooling Vest",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","CarbonCool® Cooling Vest","The CarbonCool® vest is a power-free, thermoplastic polyurethane (TPU) surface cooling device containing a proprietary carbon-based cooling medium capable of high heat exchange (35 W\u002FmK). It is designed for rapid pre-hospital application and continuous cooling during patient transport.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Shir Lynn Lim, MBBS","CONTACT","+65 91760383","shir.lynn.lim@nus.edu.sg",[28],{"facility":29,"status":30,"city":31,"state":20,"zip":32,"country":31,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"National University Heart Centre, Singapore (NUHCS)","RECRUITING","Singapore","119074","SG",{"type":35,"coordinates":36},"Point",[37,38],103.85007,1.28967,{"lat":38,"lon":37},[41,45],{"name":42,"role":24,"phone":43,"phoneExt":20,"email":44},"Kai Lee Woo","+6584136810","kai_lee_woo@nuhs.edu.sg",{"name":23,"role":46,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"type":48,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[50,52],{"name":51,"class":6},"Singapore Civil Defence Force",{"name":53,"class":6},"National University Heart Centre, Singapore","100625380","pre-hospital-cooling-to-improve-cardiac-arrest-neurological-outcomes-precedence-100625380",false,"NCT07421882","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE): a Pilot Feasibility Study","PRECEDENCE","Inclusion Criteria:\n\n1. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.\n2. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.\n3. Age ≥16 years and ≤80 years.\n4. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.\n\nExclusion Criteria:\n\n1. Age \\>80 years.\n2. Traumatic cause of cardiac arrest.\n3. Tympanic temperature \\\u003C34°C at time of assessment.\n4. Pregnant females.\n5. Termination of resuscitation in the Emergency Department.\n6. Withdrawal of life support within 24 hours of Coronary Care Unit (CCU) admission.","ALL","16 Years","80 Years",{"count":66,"type":67},50,"ESTIMATED","INTERVENTIONAL",[70],"NA","The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.",[73,74,75,76],"Out-Of-Hospital Cardiac Arrest","Cardiopulmonary Resuscitation","Death, Sudden, Cardiac","Therapeutic Hypothermia",[78],"Return of Spontaneous Circulation","2026-04-23",{"date":81,"type":82},"2026-04-29","ACTUAL",{"date":84,"type":82},"2026-02-01",{"date":86,"type":67},"2027-03",{"name":5,"class":6},1]