[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583010":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":57,"collaborators":59,"id":62,"slug":10,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":10,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":82,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Firefighter",null,"Participants employed by the Charlotte Fire Department (CFD) with at least 5 years of on-the-job experience between the ages of 40 and 49",[13,14,15],"Other: Monoclonal Gammopathy","Other: Complete Blood Count with differential (CBC w\u002F diff)","Other: Clonal hematopoiesis (CHIP)",[17,21,25],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"Monoclonal Gammopathy","Whole blood will be collected at the Baseline visit to evaluate for monoclonal gammopathy through SPEP, immunofixation, and free light chains.",[9],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Complete Blood Count with differential (CBC w\u002F diff)","Whole blood will be collected at the Baseline visit for CBC with differential which may inform a diagnosis of a plasma cell disorder or other hematological disorder.",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Clonal hematopoiesis (CHIP)","Whole blood will be collected at the Baseline visit to be evaluated using next generation sequencing (NGS) detection of CHIP. Deep NGS to identify mutations associated with myeloid neoplasms and CHIP will be performed using an error-correcting next generation sequencing multi-gene panel targeting genes most frequently mutated in CHIP.",[9],[30],{"name":31,"affiliation":5,"role":32},"Larry Druhan, PhD","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Megan Lattanze","CONTACT","980-442-4239","Megan.Lattanze@advocatehealth.org",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Levine Cancer Institute","RECRUITING","Charlotte","North Carolina","28204","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-80.84313,35.22709,{"lat":52,"lon":51},[55,56],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},{"name":31,"role":32,"phone":10,"phoneExt":10,"email":10},{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[60],{"name":61,"class":6},"Atrium Health Levine Cancer Institute","100583010",false,"NCT06870760","Pre-malignant States to Hematologic Malignancies in Firefighters","Inclusion Criteria:\n\n1. Written informed consent and HIPAA authorization for release of personal health information.\n2. Age ≥ 40-49 years at the time of consent (self-reported)\n3. Ability of the participant to understand and comply with study procedures for the entire length of the study\n4. Currently employed by Charlotte Fire Department (CFD) with at least 5 years on-the -job experience (self-reported)\n\nExclusion Criteria:\n\nAnyone with a current diagnosis of a hematologic malignancy will be excluded.",true,"ALL","40 Years","49 Years",{"count":72,"type":73},300,"ESTIMATED","OBSERVATIONAL","The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.",[77,18,78,79,80,81],"Clonal Hematopoiesis of Indeterminate Potential","Non Hodgkin Lymphoma","Leukemia","Multiple Myeloma","Plasma Cell Disorder",[83,84,85],"Firefighters","CHIP","MGUS","2026-04-13",{"date":88,"type":89},"2026-04-16","ACTUAL",{"date":91,"type":73},"2026-06",{"date":93,"type":73},"2027-04",{"name":5,"class":6},1]