[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563809":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":57,"collaborators":24,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":24,"eligibilityCriteria":66,"healthyVolunteers":63,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":24,"overallStatus":82,"whyStopped":24,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Phentolamine","EXPERIMENTAL","A loading dose of 1-5 mg IV bolus over 1 minute is given followed by an IV infusion of a rate of 0.1-2 mg\u002Fmin according to patient desired target mean arterial pressure (MAP) 50-60 mmHg over a volume of 10ml.",[13],"Drug: Phentolamine",{"label":15,"type":10,"description":16,"interventionNames":17},"Esmolol","A loading dose of 1 mg\u002Fkg IV infused over 1 minute is given followed by an IV infusion of 0.15-0.3 mg\u002Fkg\u002Fmin according to patient desired target mean arterial pressure (MAP) 50-60 mmHg over total volume of 10ml.",[18],"Drug: Esmolol",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","A loading dose of 1-5 mg IV bolus over 1 minute is given followed by an IV infusion of a rate of 0.1-2 mg\u002Fmin according to patient desired target mean arterial pressure (MAP) 50-60 mmHg over a volume of 10ml",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"A loading dose of 1 mg\u002Fkg IV infused over 1 minute is given followed by an IV infusion of 0.15-0.3 mg\u002Fkg\u002Fmin according to patient desired target mean arterial pressure (MAP) 50-60 mmHg over total volume of 10ml",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Eslam A Elsamahi, Master","CONTACT","00201069503729","eslam.ahmed@med.asu.edu.eg",[35],{"facility":5,"status":24,"city":36,"state":24,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Cairo","11591","Egypt","EG",{"type":41,"coordinates":42},"Point",[43,44],31.24967,30.06263,{"lat":44,"lon":43},[47,48,51,53,55],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},{"name":49,"role":50,"phone":24,"phoneExt":24,"email":24},"Hala G Salama, MD","SUB_INVESTIGATOR",{"name":52,"role":50,"phone":24,"phoneExt":24,"email":24},"Hatem S Abdelhamid, MD",{"name":54,"role":50,"phone":24,"phoneExt":24,"email":24},"Mohamed A Ibrahim, MD",{"name":56,"role":50,"phone":24,"phoneExt":24,"email":24},"Mohamed N Mohamed, MD",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Eslam Elsamahi","Assistant lecturer of intensive care unit and anesthesia, Faculty of Medicine, Ain Shams University, Egypt.","100563809","pre-operative-phentolamine-vs-intraoperative-esmolol-efficacy-for-hypotensive-anesthesia-in-functional-endoscopic-sinus-surgery-100563809",false,"NCT06620991","Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery","Inclusion Criteria:\n\n* Age from 21 to 50 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n\nExclusion Criteria:\n\n* Patients with a medical condition that contraindicated hypotensive anesthesia, such as peripheral vascular disease, cerebrovascular stroke, carotid artery stenosis, previous myocardial infarction, ischemic heart disease, congestive heart failure, limb ischemia, uncontrolled hypertension and raised intracranial tension\n* Renal disease, liver dysfunction, pregnancy.\n* Patients on hypnotic or narcotic analgesic.\n* History of alcohol or drug abuse.\n* History of allergic reaction to any drug used in this study.\n* Bleeding diathesis.\n* Previous nasal surgery.\n* Patients on Non-steroidal anti-inflammatory drugs (NSAIDs).\n* Patients with peripheral vascular disease.","ALL","21 Years","50 Years",{"count":71,"type":72},60,"ESTIMATED","INTERVENTIONAL",[75],"NA","The aim of this study is to evaluate the efficacy of intra-operative phentolamine vs intraoperative esmolol for hypotensive anesthesia in functional endoscopic sinus surgery.",[78,9,79,15,80,81],"Preoperative","Intraoperative","Hypotensive Anesthesia","Functional Endoscopic Sinus Surgery","NOT_YET_RECRUITING","2024-09-29",{"date":85,"type":86},"2024-10-01","ACTUAL",{"date":88,"type":72},"2024-10-10",{"date":90,"type":72},"2025-04-01",{"name":5,"class":6},1]